Role of γ-globulin-associated fraction containing carbohydrate component inin vitro regulation of human natural killer activity

Abstract

Carbohydrate-rich components released from fractions of aggregated and protein aggregatefree T-globulins decreased the cytotoxicity of natural killer cells in relation 3H-uridine-labeled standard human K562 erythroblasts. In a dose of 0.1 ~tg/ml, these components decreased activity of natural killer lymphocytes by 57% and 42%, respectively. The data suggest that T-globulin-associated fractions containing carbohydrate components are involved in the regulation of human natural killer activity.