Roles and Mechanisms of NLRP3 in Influenza Viral Infection

Niu, Jianlou; Meng, Guangxun

doi:10.3390/v15061339

Cited by 5 publications

(3 citation statements)

References 179 publications

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“…The human gut microbiota consists of approximately 10 14 microorganisms and plays a crucial role in host function, especially in immunity and metabolism ( Tao et al., 2022 ; Niu and Meng, 2023 ). Many studies demonstrated that the gut microbiota is closely interrelated with GBC progression, but most relative mechanistic studies have primarily focused on bacteria.…”

Section: Bacteria In Gbc Pathogenesismentioning

confidence: 99%

The footprint of gut microbiota in gallbladder cancer: a mechanistic review

Liu,

Li,

Chen

et al. 2024

Front. Cell. Infect. Microbiol.

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Gallbladder cancer (GBC) is the most common malignant tumor of the biliary system with the worst prognosis. Even after radical surgery, the majority of patients with GBC have difficulty achieving a clinical cure. The risk of tumor recurrence remains more than 65%, and the overall 5-year survival rate is less than 5%. The gut microbiota refers to a variety of microorganisms living in the human intestine, including bacteria, viruses and fungi, which profoundly affect the host state of general health, disease and even cancer. Over the past few decades, substantial evidence has supported that gut microbiota plays a critical role in promoting the progression of GBC. In this review, we summarize the functions, molecular mechanisms and recent advances of the intestinal microbiota in GBC. We focus on the driving role of bacteria in pivotal pathways, such as virulence factors, metabolites derived from intestinal bacteria, chronic inflammatory responses and ecological niche remodeling. Additionally, we emphasize the high level of correlation between viruses and fungi, especially EBV and Candida spp., with GBC. In general, this review not only provides a solid theoretical basis for the close relationship between gut microbiota and GBC but also highlights more potential research directions for further research in the future.

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Section: Bacteria In Gbc Pathogenesismentioning

confidence: 99%

The footprint of gut microbiota in gallbladder cancer: a mechanistic review

Liu,

Li,

Chen

et al. 2024

Front. Cell. Infect. Microbiol.

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“…Influenza virus infection is a significant example; the activation of the NLRP3 inflammasome is closely related to the immune response. In the early stages of IAV infection (the first five days after infection), the activation of NLRP3 triggers the release of inflammatory factors such as IL-1 β and IL-18, which help recruit immune cells and improve their ability to fight the virus [ 15 ]. Cytomegalovirus infection also shows signs that NLRP3 may play an antiviral effect.…”

Section: Activation Of Nlrp3mentioning

confidence: 99%

Investigating the Nexus of NLRP3 Inflammasomes and COVID-19 Pathogenesis: Unraveling Molecular Triggers and Therapeutic Strategies

He,

Hu,

Zheng

et al. 2024

Viruses

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The coronavirus disease 2019 (COVID-19) global pandemic, caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), has been marked by severe cases demonstrating a “cytokine storm”, an upsurge of pro-inflammatory cytokines in the bloodstream. NLRP3 inflammasomes, integral to the innate immune system, are speculated to be activated by SARS-CoV-2 within host cells. This review investigates the potential correlation between NLRP3 inflammasomes and COVID-19, exploring the cellular and molecular mechanisms through which SARS-CoV-2 triggers their activation. Furthermore, promising strategies targeting NLRP3 inflammasomes are proposed to mitigate the excessive inflammatory response provoked by SARS-CoV-2 infection. By synthesizing existing studies, this paper offers insights into NLRP3 as a therapeutic target, elucidating the interplay between COVID-19 and its pathophysiology. It serves as a valuable reference for future clinical approaches in addressing COVID-19 by targeting NLRP3, thus providing potential avenues for therapeutic intervention.

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“…After influenza virus invasion, viral ribonucleoproteins are released into the nucleus for transcription and replication. SsRNA is recognized by TLR7 and triggers the expression of NF-kB, pro-IL-1b, pro-IL-18, and other proinflammatory cytokines (Niu and Meng, 2023). Studies have shown a lack of IL-1b release by infecting influenza virus into TLR7-deficient bone marrow-derived DCs (Ichinohe et al, 2010).…”

Section: Influenza Virus Infection and Nlrp3 Inflammasomementioning

confidence: 99%

Regulation and functions of the NLRP3 inflammasome in RNA virus infection

Yue,

Zhang,

et al. 2024

Front. Cell. Infect. Microbiol.

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Virus infection is one of the greatest threats to human life and health. In response to viral infection, the host’s innate immune system triggers an antiviral immune response mostly mediated by inflammatory processes. Among the many pathways involved, the nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome has received wide attention in the context of viral infection. The NLRP3 inflammasome is an intracellular sensor composed of three components, including the innate immune receptor NLRP3, adaptor apoptosis-associated speck-like protein containing CARD (ASC), and the cysteine protease caspase-1. After being assembled, the NLRP3 inflammasome can trigger caspase-1 to induce gasdermin D (GSDMD)-dependent pyroptosis, promoting the maturation and secretion of proinflammatory cytokines such as interleukin-1 (IL-1β) and interleukin-18 (IL-18). Recent studies have revealed that a variety of viruses activate or inhibit the NLRP3 inflammasome via viral particles, proteins, and nucleic acids. In this review, we present a variety of regulatory mechanisms and functions of the NLRP3 inflammasome upon RNA viral infection and demonstrate multiple therapeutic strategies that target the NLRP3 inflammasome for anti-inflammatory effects in viral infection.

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Roles and Mechanisms of NLRP3 in Influenza Viral Infection

Cited by 5 publications

References 179 publications

The footprint of gut microbiota in gallbladder cancer: a mechanistic review

The footprint of gut microbiota in gallbladder cancer: a mechanistic review

Investigating the Nexus of NLRP3 Inflammasomes and COVID-19 Pathogenesis: Unraveling Molecular Triggers and Therapeutic Strategies

Regulation and functions of the NLRP3 inflammasome in RNA virus infection

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