Roles for central leptin receptors in the control of meal size

Schwartz, Gary J.; Azzara, Anthony V.; Heaner, Martica

doi:10.1016/j.appet.2013.04.017

Cited by 7 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results suggest that the regulation of adiponectin and its receptors is model-dependent. Leptin is the principal adipostatic signaling pathway that controls appetite, food intake, and endocrine function to maintain energy balance in mammals, and leptin receptors (LepR) are present in multiple peripheral and central tissues (reviewed in 27). Leptin acts as a pro-fibrotic cytokine in the liver and is known to contribute to hepatic fibrosis during NAFLD (reviewed in 28, 29).…”

Section: Resultsmentioning

confidence: 99%

High Protein/Fish Oil Diet Prevents Hepatic Steatosis in NONcNZO10 Mice; Association with Diet/Genetics-regulated Micro-RNAs

Adi

Lassance‐Soares

et al. 2016

J Diabetes Metab

View full text Add to dashboard Cite

Objective NONcNZO10 (NZ10) mice are predisposed to obesity and develop type 2 diabetes (T2D) and hepatic steatosis even when maintained on a control diet (CD) of 6% fat. Studies were designed to determine whether this extreme susceptibility phenotype could be alleviated by diet and if so the molecular targets of diet. Methods NZ10 and SWR/J (SWR) control mice were fed a CD or a test diet of high protein and fish oil (HPO) for 19 weeks and then analyzed for steatosis, blood chemistry, hepatic gene and micro-RNA expression. Results HPO diet prevented steatosis, significantly increased serum adiponectin and reduced serum cholesterol and triglycerides only in NZ10 mice. The HPO diet repressed hepatic expression of fatty acid metabolic regulators including PPAR-γ, sterol regulatory element-binding protein-c1, peroxisome proliferator-activated receptor gamma co-activator-1, fatty acid synthase, fatty acid binding protein-4, and apolipoprotein A4 genes only in NZ10 mice. Also repressed by a HPO diet were adiponectinR2 receptor, leptin-R, PPAR-α, pyruvate dehydrogenase kinase isoforms 2 and 4, AKT2 and GSK3β. Micro-RNA (miR) arrays identified miRs that were diet and/or genetics regulated. QRTPCR confirmed increased expression of miR-205 and suppression of a series of miRs including miRs-411, 155, 335 and 21 in the NZ10-HPO group, each of which are implicated in the progression of diabetes and/or steatosis. Evidence is presented that miR-205 co-regulates with PPARγ and may regulate fibrosis and EMT during the progression of steatosis in the livers of NZ10-CD mice. The dietary responses of miR-205 are tissue-specific with opposite effects in adipose and liver. Conclusion The results confirm that a HPO diet overrides the genetic susceptibility of NZ10 mice and this correlates with the suppression of key genes and perhaps micro-RNAs involved in hyperglycemia, dyslipidemia and inflammation including master PPAR regulators, adiponectin and leptin receptors.

show abstract

Section: Resultsmentioning

confidence: 99%

High Protein/Fish Oil Diet Prevents Hepatic Steatosis in NONcNZO10 Mice; Association with Diet/Genetics-regulated Micro-RNAs

Adi

Lassance‐Soares

et al. 2016

J Diabetes Metab

View full text Add to dashboard Cite

show abstract

“…Patients with leptin deficiency or LepR mutation also develop severe obesity (8,9). It is evident that hypothalamic LepR (10,11) is critical for leptinmediated regulation of energy metabolism, as impairment of LepR signaling in the hypothalamus selectively results in hyperphagia and adiposity (1,12,13).…”

mentioning

confidence: 99%

The Acute-Phase Protein Orosomucoid Regulates Food Intake and Energy Homeostasis via Leptin Receptor Signaling Pathway

et al. 2016

View full text Add to dashboard Cite

The acute-phase protein orosomucoid (ORM) exhibits a variety of activities in vitro and in vivo, notably modulation of immunity and transportation of drugs. We found in this study that mice lacking ORM1 displayed aberrant energy homeostasis characterized by increased body weight and fat mass. Further investigation found that ORM, predominantly ORM1, is significantly elevated in sera, liver, and adipose tissues from the mice with high-fat diet (HFD)-induced obesity and db/db mice that develop obesity spontaneously due to mutation in the leptin receptor (LepR). Intravenous or intraperitoneal administration of exogenous ORM decreased food intake in C57BL/6, HFD, and leptin-deficient ob/ob mice, which was absent in db/db mice and was significantly reduced in mice with arcuate nucleus (ARC) LepR knockdown, whereas enforced expression of ORM1 in ARC significantly decreased food intake, body weight, and serum insulin level. Furthermore, we found that ORM is able to bind directly to LepR and activate the receptor-mediated JAK2-STAT3 signaling in hypothalamus tissue and GT1-7 cells, which was derived from hypothalamic tumor. These data indicated that ORM could function through LepR to regulate food intake and energy homeostasis in response to nutrition status. Modulating the expression of ORM is a novel strategy for the management of obesity and related metabolic disorders.

show abstract

“…It is known that alcohols, as components (tribromoethanol, ethanol, and amyl alcohol) of avertin, are distributed to the white adipose tissue and affect the physiological properties of the adipocyte [25]. Adipose tissue secretes more than 50 adipokines, including leptin, which are related to glucose, lipid, energy metabolism, and appetite regulation [1, 25, 26]. Although there is no evidence indicating that a component of avertin affects the secretion or production of these adipokines, leading to alteration of energy metabolism, it could be considered that the avertin is prone to causing an adverse effect in individuals with a larger fat mass.…”

Section: Discussionmentioning

confidence: 99%

The effect of avertin anesthesia and a mixture of three types of anesthetic agents on food intakeand body weight in high fat-induced obese maleand female mice

et al. 2019

View full text Add to dashboard Cite

Basic research on obesity is becoming more important due to an increasing number of obese people. Experiments using obesity-model animals often require surgical interventions, such as gastric operation, and proper selection of anesthesia is important. Avertin, an agent mainly composed of 2,2,2-Tribromoethanol, has been used as general anesthesia for a long time, without the use of narcotic drugs. In the current study, we found that a single injection of avertin can decrease body weight (BW) in male and female C57BL/6J and ICR mice with high fat-diet (HFD)-induced obesity, but not in standard diet-fed nonobese males and females. Because the BW-reducing effect was more prominent in the female mice, we compared the effects of avertin and a mixture of three types of anesthetic agents (3MIX), which was developed in 2011, on BW reduction in HFD-induced obese female mice. Although both avertin and 3MIX decreased food intake and BW, the effects of avertin were significantly more potent than those of 3MIX. C-Fos expression, a neural activation marker, was dramatically increased in the brain regions related to the regulation of both food intake and the autonomic nervous system after avertin injection, but not after 3MIX injection. This suggests that avertin strongly stimulates the center of feeding regulation and the autonomic nervous system and therefore decreases BW. The current study suggests the advantages of using 3MIX for surgical interventions in mice in obesity research, as it is ideal to prevent anesthesia-induced BW decline.

show abstract

Roles for central leptin receptors in the control of meal size

Cited by 7 publications

References 17 publications

High Protein/Fish Oil Diet Prevents Hepatic Steatosis in NONcNZO10 Mice; Association with Diet/Genetics-regulated Micro-RNAs

High Protein/Fish Oil Diet Prevents Hepatic Steatosis in NONcNZO10 Mice; Association with Diet/Genetics-regulated Micro-RNAs

The Acute-Phase Protein Orosomucoid Regulates Food Intake and Energy Homeostasis via Leptin Receptor Signaling Pathway

The effect of avertin anesthesia and a mixture of three types of anesthetic agents on food intakeand body weight in high fat-induced obese maleand female mice

Contact Info

Product

Resources

About