Roles of 5-HT3 and 5-HT7 receptors in acute pruriceptive processing in mice

Differential Contribution of 5-HT₄, 5-HT₅, and 5-HT₆ Receptors to Acute Pruriceptive Processing Induced by Chloroquine and Histamine in Mice

“…In contrast, the intrathecal injection of 5-HT dose-dependently reduced CQ-induced scratches. 7) Similarly, pruritogen-induced scratches were mitigated by the administration of 5-HT, 17) indicating that scratches induced by pruritogens are ameliorated by an increase in the concentration of 5-HT. Therefore, the relationship between the amount of 5-HT and its effects on pruritogen-evoked scratches remains controversial.…”

“…Scratches were used to evaluate the induction of pruritus as previously described. 6,7) Scratching behavior is defined as the rapid, repetitive, and back-and-forth movement of the hind paw toward the injection site. Mice were treated with 10 µg of saline, milnacipran, or mirtazapine, followed by the treatment of 500 µg of histamine or 200 µg of CQ in a volume of 50 µl.…”

“…6) A previous study showed the involvement of 5-HT3 and 5-HT7 receptors in scratching events induced by CQ or histamine. 7) Therefore, to examine whether 5-HT4, 5-HT5, and 5-HT6 receptors are involved in the effects of these antidepressants on either scratching behavior, various doses of SB207266, SB699551, or SB258585 were intrathecally injected, CQ or histamine was injected 5 min later, and the induction of scratches were then assessed for 15 min. Furthermore, to reconfirm whether the 5-HT4 or 5-HT6 receptors contribute to the effects of these antidepressants, various concentrations of BIMU8, ML10302, or WAY208466 were administered before the intradermal injection of CQ or histamine, and their effects were evaluated based on changes in the numbers of scratching events for 15 min.…”

The 5‐HT1A receptor agonist, 8‐OH‐DPAT, attenuates long‐lasting pain in imiquimod‐induced psoriasis in mice

“…The 5‐HT 1A receptor is involved in the pain and inflammation inhibition whereas the activation of 5‐HT 2A R induces the lymphocyte's recruitment into the skin 12‐14 . Moreover, the 5‐HT 7 and 5‐HT 3 receptors are implicated in the pruritus response 15 . Specific serotonin reuptake inhibitors used to treat psoriasis comorbidities have a positive effect on dermatological psoriasis symptoms, which suggests that the serotoninergic system could be involved in psoriasis development 16 …”

“…[12][13][14] Moreover, the 5-HT 7 and 5-HT 3 receptors are implicated in the pruritus response. 15 Specific serotonin reuptake inhibitors used to treat psoriasis comorbidities have a positive effect on dermatological psoriasis symptoms, which suggests that the serotoninergic system could be involved in psoriasis development. 16 This work aimed to investigate the development of secondary chronic ALD and HYP in IMQ-induced psoriasis and to study how these nociceptive behaviours can be modulated by the presence of anti-inflammatory agents and compound 48/80.…”