Roles of ADAM8 in elimination of injured muscle fibers prior to skeletal muscle regeneration

Nishimura, Daigo; Sakai, Hiroshi; Sato, Takahiko; Sato, Fuminori; Nishimura, Satoshi; Toyama–Sorimachi, Noriko; Bartsch, Jörg W.; Sehara-Fujisawa, Atsuko

doi:10.1016/j.mod.2014.12.001

Cited by 24 publications

(22 citation statements)

References 35 publications

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“…In agreement with our data, an increase in the expression of ADAM8 mRNA has been described in skin samples of SSc patients with leukocyte infiltration (Greenblatt et al, 2012). PSGL-1 is a target of ADAM8 (Domínguez-Luis et al, 2011;Gó mez-Gaviro et al, 2007;Nishimura et al, 2015); hence, the elevated levels of ADAM8 on SSc leukocytes could lead to a higher shedding of PSGL-1 when activated by other stimuli such as infections or tissue damage, decreasing the modulatory signals provided by PSGL-1 to the immune system. Supporting this notion, it was reported that a cohort of Japanese SSc patients presented higher concentrations of soluble PSGL-1 in serum (Yanaba et al, 2004).…”

Section: Discussionsupporting

confidence: 90%

Deregulated PSGL-1 Expression in B Cells and Dendritic Cells May Be Implicated in Human Systemic Sclerosis Development

Silván

Rafael

Vicente-Rabaneda

et al. 2018

Journal of Investigative Dermatology

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Systemic sclerosis (SSc) is an autoimmune disorder with high morbidity and mortality, is difficult to diagnose early, and has no curative treatment. PSGL-1 is a leukocyte receptor whose deficiency in mice promotes an SSc-like disease. ADAM8, a metalloprotease that cleaves PSGL-1, is implicated in inflammatory processes. Our goal was to evaluate whether PSGL-1 and ADAM8 contribute to the pathogenesis of human SSc. We found that patients with SSc presented increased PSGL-1 expression on monocytes, dendritic cells, and T cells and decreased expression of PSGL-1 on B cells. PSGL-1 on monocytes from SSc patients failed to induce Syk phosphorylation or IL-10 production after interaction with P-selectin. Up to 60% of the IL-10-producing B cells expressed PSGL-1, pointing to a regulatory role for PSGL-1 in B cells, and PSGL-1 B cells from SSc patients had decreased IL-10 production. ADAM8 expression was increased on antigen-presenting cells and T lymphocytes of SSc patients. Patients treated with calcium antagonists had lower levels of ADAM8 on APCs and T lymphocytes. Multivariate analysis indicated that the high percentage of ADAM8-expressing plasmacytoid dendritic cells discriminated patients from healthy donors. High PSGL-1 expression on dendritic cells was associated with the presence of interstitial lung disease.

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Section: Discussionsupporting

confidence: 90%

Deregulated PSGL-1 Expression in B Cells and Dendritic Cells May Be Implicated in Human Systemic Sclerosis Development

Silván

Rafael

Vicente-Rabaneda

et al. 2018

Journal of Investigative Dermatology

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“…5F). Adam8 encodes a metalloprotease associated with skeletal muscle regeneration (38). Adam8 has not been previously linked to limb regeneration.…”

Section: Regeneration-specific Expression Pattern Of Select Genes Inmentioning

confidence: 99%

Deep evolutionary origin of limb and fin regeneration

Darnet

Dragalzew

Amaral

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Salamanders and lungfishes are the only sarcopterygians (lobe-finned vertebrates) capable of paired appendage regeneration, regardless of the amputation level. Among actinopterygians (ray-finned fishes), regeneration after amputation at the fin endoskeleton has only been demonstrated in polypterid fishes (Cladistia). Whether this ability evolved independently in sarcopterygians and actinopterygians or has a common origin remains unknown. Here we combine fin regeneration assays and comparative RNA-sequencing (RNA-seq) analysis of Polypterus and axolotl blastemas to provide support for a common origin of paired appendage regeneration in Osteichthyes (bony vertebrates). We show that, in addition to polypterids, regeneration after fin endoskeleton amputation occurs in extant representatives of 2 other nonteleost actinopterygians: the American paddlefish (Chondrostei) and the spotted gar (Holostei). Furthermore, we assessed regeneration in 4 teleost species and show that, with the exception of the blue gourami (Anabantidae), 3 species were capable of regenerating fins after endoskeleton amputation: the white convict and the oscar (Cichlidae), and the goldfish (Cyprinidae). Our comparative RNA-seq analysis of regenerating blastemas of axolotl and Polypterus reveals the activation of common genetic pathways and expression profiles, consistent with a shared genetic program of appendage regeneration. Comparison of RNA-seq data from early Polypterus blastema to single-cell RNA-seq data from axolotl limb bud and limb regeneration stages shows that Polypterus and axolotl share a regeneration-specific genetic program. Collectively, our findings support a deep evolutionary origin of paired appendage regeneration in Osteichthyes and provide an evolutionary framework for studies on the genetic basis of appendage regeneration.

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“…Invading neutrophils release proteolytic enzymes (e.g. ADAM-8 [40]) to degrade damaged muscle cells. The waning neutrophil influx is followed 24–48 h later by arrival of proinflammatory M1 macrophages and eosinophils recruited via cell-specific chemoattractants (e.g.…”

Section: Injury Inflammation and Nonsteroidal Anti-inflammatory Drugsmentioning

confidence: 99%

The roles of injury and nonsteroidal anti-inflammatory drugs in the development and outcomes of severe group A streptococcal soft tissue infections

Bryant

Bayer

Aldape

et al. 2015

Current Opinion in Infectious Diseases

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Purpose of review This review summarizes clinical and basic science evidence linking trauma and nonsteroidal anti-inflammatory drug (NSAID) use to initiation and progression of severe group A streptococcal (GAS) soft tissue infection. Recent findings New evidence includes recent clinical series and controlled studies that lend support to an NSAID/GAS association, basic science studies that demonstrate unique roles for nonpenetrating injury and NSAID administration in initiation of cryptogenic GAS infection and experimental studies showing that nonselective NSAIDs accelerate disease progression and limit antibiotic efficacy in established GAS soft tissue infections. Potential mechanisms for these processes are discussed. Summary NSAIDs are important anti-inflammatory and analgesic drugs; however, new experimental data suggest that nonselective NSAIDs do more than simply mask the signs and symptoms of developing GAS infection. A more thorough understanding of the triadic interplay of injury-triggered immune signaling, GAS soft tissue infection and NSAIDs is of significant clinical importance and could shift the current paradigm of pain management to avert the consequences of such devastating infections.

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Roles of ADAM8 in elimination of injured muscle fibers prior to skeletal muscle regeneration

Cited by 24 publications

References 35 publications

Deregulated PSGL-1 Expression in B Cells and Dendritic Cells May Be Implicated in Human Systemic Sclerosis Development

Deregulated PSGL-1 Expression in B Cells and Dendritic Cells May Be Implicated in Human Systemic Sclerosis Development

Deep evolutionary origin of limb and fin regeneration

The roles of injury and nonsteroidal anti-inflammatory drugs in the development and outcomes of severe group A streptococcal soft tissue infections

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