2020
DOI: 10.3390/ijms21218308
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Roles of Adipokines in Digestive Diseases: Markers of Inflammation, Metabolic Alteration and Disease Progression

Abstract: Adipose tissue is a highly dynamic endocrine tissue and constitutes a central node in the interorgan crosstalk network through adipokines, which cause pleiotropic effects, including the modulation of angiogenesis, metabolism, and inflammation. Specifically, digestive cancers grow anatomically near adipose tissue. During their interaction with cancer cells, adipocytes are reprogrammed into cancer-associated adipocytes and secrete adipokines to affect tumor cells. Moreover, the liver is the central metabolic hub… Show more

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Cited by 64 publications
(58 citation statements)
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References 296 publications
(348 reference statements)
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“…Recently, it was reported that treatment with a dual AdipoR1/AdipoR2 agonist improved both NASH and fibrosis in mice models via reduced hepatic stellate cell activation [ 90 ] ( Figure 2 ). While several observational studies have reported elevated serum levels of other obesity-related adipokines, such as resistin, visfatin, and RBP4 in NAFLD patients, some contradictory results have also been reported, suggesting that the causal relationship between these adipokines and NAFLD remains under debate [ 91 , 92 ].…”
Section: Factors Underlying the Pathogenesis Of Mafldmentioning
confidence: 99%
“…Recently, it was reported that treatment with a dual AdipoR1/AdipoR2 agonist improved both NASH and fibrosis in mice models via reduced hepatic stellate cell activation [ 90 ] ( Figure 2 ). While several observational studies have reported elevated serum levels of other obesity-related adipokines, such as resistin, visfatin, and RBP4 in NAFLD patients, some contradictory results have also been reported, suggesting that the causal relationship between these adipokines and NAFLD remains under debate [ 91 , 92 ].…”
Section: Factors Underlying the Pathogenesis Of Mafldmentioning
confidence: 99%
“…Epidemiological studies suggest an association between decreased serum levels of adiponectin and the risk of colorectal cancer. In contrast, the expression of adiponectin receptors (R1 and R2) shows much more variable expression in cancerous tissue (higher or lower compared to controls) (reviewed in: [ 119 ]). Unfortunately, a description of the exact function of this protein in the mechanisms of CRC-associated cachexia is still absent.…”
Section: The Role Of Tumor Microenvironment (Tme) Cells In Crc-assmentioning
confidence: 99%
“…In particular, the difference between HCV-untreated and HCV-uninfected cohorts could be due to random variation. Fourth, the precise mechanism of the increased risk of esophageal cancer in HCV-infected patients was undetermined, and some documented risks for esophageal cancer, such as alcohol, smoking, betel nut chewing [ 4 ], MetS [ 6 , 29 ], hypertension [ 35 ], and obesity [ 7 ] cannot be identified from the TNHIRD. Fifth, the ICD-9 CM code cannot differentiate ESCC and EAC.…”
Section: Discussionmentioning
confidence: 99%
“…The risk factors for esophageal SCC include alcohol, smoking, betel nut chewing [ 4 ], and hypertension [ 5 ]. Metabolic syndrome (MetS) [ 6 ] and body mass index (BMI)/obesity [ 5 , 7 ] are related to a higher risk of EAC. In contrast, a high BMI significantly decreases the risk of ESCC [ 5 ].…”
Section: Introductionmentioning
confidence: 99%