2024
DOI: 10.3389/fcimb.2024.1346087
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Roles of airway and intestinal epithelia in responding to pathogens and maintaining tissue homeostasis

Marcela Ambrogi,
Chad M. Vezina

Abstract: Epithelial cells form a resilient barrier and orchestrate defensive and reparative mechanisms to maintain tissue stability. This review focuses on gut and airway epithelia, which are positioned where the body interfaces with the outside world. We review the many signaling pathways and mechanisms by which epithelial cells at the interface respond to invading pathogens to mount an innate immune response and initiate adaptive immunity and communicate with other cells, including resident microbiota, to heal damage… Show more

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