Roles of autophagy in relation to mitochondrial stress responses of HeLa cells to lamellarin cytotoxicity

Sopha, Pattarawut; Phutubtim, Nadgrita; Chantrathonkul, Bunkuea; Ploypradith, Poonsakdi; Ruchirawat, Somsak; Chittchang, Montakarn

doi:10.1016/j.tox.2021.152963

Cited by 10 publications

(4 citation statements)

References 51 publications

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“…c, Bax, and MMP [ 120 ]. Lamellarin D, a powerful marine alkaloid isolated from the marine mollusk Lamellaria, has been shown to block topoisomerase I and other signaling pathways, resulting in cytotoxic and antitumoral impacts in leukemia cells (p388) [ 121 , 122 , 123 ]. Lamellarin D increased the rate of Bax, stimulated the activity of caspase-3, caspase-9, and decreased Bcl-2, which led to mitochondrial malfunction and apoptosis in p388 leukemia cells [ 121 , 124 ].…”

Section: Marine Compounds Suppress Cancer Through the Modulation Of M...mentioning

confidence: 99%

Marine Compounds, Mitochondria, and Malignancy: A Therapeutic Nexus

et al. 2022

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The marine environment is important yet generally underexplored. It contains new sources of functional constituents that can affect various pathways in food processing, storage, and fortification. Bioactive secondary metabolites produced by marine microorganisms may have significant potential applications for humans. Various components isolated from disparate marine microorganisms, including fungi, microalgae, bacteria, and myxomycetes, showed considerable biological effects, such as anticancer, antioxidant, antiviral, antibacterial, and neuroprotective activities. Growing studies are revealing that potential anticancer effects of marine agents could be achieved through the modulation of several organelles. Mitochondria are known organelles that influence growth, differentiation, and death of cells via influencing the biosynthetic, bioenergetic, and various signaling pathways related to oxidative stress and cellular metabolism. Consequently, mitochondria play an essential role in tumorigenesis and cancer treatments by adapting to alterations in environmental and cellular conditions. The growing interest in marine-derived anticancer agents, combined with the development and progression of novel technology in the extraction and cultures of marine life, led to revelations of new compounds with meaningful pharmacological applications. This is the first critical review on marine-derived anticancer agents that have the potential for targeting mitochondrial function during tumorigenesis. This study aims to provide promising strategies in cancer prevention and treatment.

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Section: Marine Compounds Suppress Cancer Through the Modulation Of M...mentioning

confidence: 99%

Marine Compounds, Mitochondria, and Malignancy: A Therapeutic Nexus

et al. 2022

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“…4,5 The biological spectrum of lamellarins is manifold, with pronounced cytotoxic activity. [6][7][8][9][10][11] In detail, lamellarin D (Fig. 1), a leading compound in the family of type I, induces its anticancer activity through topoisomerase I inhibition and mitochondrial targeting that triggers cell death.…”

Section: Introductionmentioning

confidence: 99%

Pyrazole-based lamellarin O analogues: synthesis, biological evaluation and structure–activity relationships

et al. 2023

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“…type-II, are less structurally complex non-fused compounds, mainly diversely substituted pyrrole-2-carboxylate derivatives. These natural products are noteworthy for their structural diversity and useful pharmacological properties, such as anticancer, [33][34][35][36][37] multidrug resistance reversal, 38,39 cytotoxic, HIV-1 integrase inhibitory 40,41 and T790M/C797S mutant epidermal growth factor receptor restraint activities. 42 Recently, some lamellarin sulfates 43 were isolated and elucidated by R. A. Keyzers from the methanolic extract of the Pacific tunicate Didemnum ternerratum, collected from the Kingdom of Tonga, and have been reported to exhibit moderate cytotoxicity against the human colon carcinoma cell line HCT-116.…”

Section: Introductionmentioning

confidence: 99%