Roles of calcium and IP3 in impaired colon contractility of rats following multiple organ dysfunction syndrome

Zheyu, C.; Qi, Qing-Hui; Yan, Lü-Nan

doi:10.1590/s0100-879x2006005000147

Cited by 5 publications

(2 citation statements)

References 40 publications

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“…In support of this hypothesis, several previous studies clearly showed that gut stasis leads to elevated gut permeability and bacterial translocation ( 75 , 84 – 87 ). This ultimately releases toxic mediators which further increases gut permeability ( 88 – 91 ). Conversely, alterations in the gut microbiota may to be involved in some neurological and autoimmune conditions ( 92 ), especially MS ( 93 ).…”

Section: Intestinal Calcium Absorption Gut Microbiota and Multiple mentioning

confidence: 99%

Latitude, Vitamin D, Melatonin, and Gut Microbiota Act in Concert to Initiate Multiple Sclerosis: A New Mechanistic Pathway

et al. 2018

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Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). While the etiology of MS is still largely unknown, scientists believe that the interaction of several endogenous and exogenous factors may be involved in this disease. Epidemiologists have seen an increased prevalence of MS in countries at high latitudes, where the sunlight is limited and where the populations have vitamin D deficiency and high melatonin levels. Although the functions and synthesis of vitamin D and melatonin are contrary to each other, both are involved in the immune system. While melatonin synthesis is affected by light, vitamin D deficiency may be involved in melatonin secretion. On the other hand, vitamin D deficiency reduces intestinal calcium absorption leading to gut stasis and subsequently increasing gut permeability. The latter allows gut microbiota to transfer more endotoxins such as lipopolysaccharides (LPS) into the blood. LPS stimulates the production of inflammatory cytokines within the CNS, especially the pineal gland. This review summarizes the current findings on the correlation between latitude, sunlight and vitamin D, and details their effects on intestinal calcium absorption, gut microbiota and neuroinflammatory mediators in MS. We also propose a new mechanistic pathway for the initiation of MS.

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Section: Intestinal Calcium Absorption Gut Microbiota and Multiple mentioning

confidence: 99%

Latitude, Vitamin D, Melatonin, and Gut Microbiota Act in Concert to Initiate Multiple Sclerosis: A New Mechanistic Pathway

et al. 2018

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“…The adequate relationship between GI physiology and overall homeostasis involves a variety of delicate functions; among these, the participation of gut motility, intestinal epithelial secretion and visceral perception mechanisms in association to systemic alterations have been somewhat explored (Duclos et al, 1991; Lackner et al, 2004; Zheyu et al, 2007; Yamamoto et al, 2008; Diebel et al, 2015; Yamamoto-Furusho et al, 2015). However, the contribution of other complex responses such as those regulated by the ENS or the intestinal epithelial barrier to the development of GI and extraintestinal disorders are still largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Investigating Gut Permeability in Animal Models of Disease

et al. 2019

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A growing number of investigations report the association between gut permeability and intestinal or extra-intestinal disorders under the basis that translocation of gut luminal contents could affect tissue function, either directly or indirectly. Still, in many cases it is unknown whether disruption of the gut barrier is a causative agent or a consequence of these conditions. Adequate experimental models are therefore required to further understand the pathophysiology of health disorders associated to gut barrier disruption and to develop and test pharmacological treatments. Here, we review the current animal models that display enhanced intestinal permeability, and discuss (1) their suitability to address mechanistic questions, such as the association between gut barrier alterations and disease and (2) their validity to test potential treatments for pathologies that are characterized by enhanced intestinal permeability.

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IL-6, TNF-α, and iNOS is associated with decreased colonic contraction in rats with multiple organ dysfunction syndrome

Xiong

Chen

2012

Journal of Surgical Research

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Roles of calcium and IP3 in impaired colon contractility of rats following multiple organ dysfunction syndrome

Cited by 5 publications

References 40 publications

Latitude, Vitamin D, Melatonin, and Gut Microbiota Act in Concert to Initiate Multiple Sclerosis: A New Mechanistic Pathway

Latitude, Vitamin D, Melatonin, and Gut Microbiota Act in Concert to Initiate Multiple Sclerosis: A New Mechanistic Pathway

Investigating Gut Permeability in Animal Models of Disease

IL-6, TNF-α, and iNOS is associated with decreased colonic contraction in rats with multiple organ dysfunction syndrome

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