Roles of CatSper channels in the pathogenesis of asthenozoospermia and the therapeutic effects of acupuncture-like treatment on asthenozoospermia

Jin, Zi-Run; Fang, Dong; Liu, Bo-Heng; Cai, Jie; Tang, Wenhao; Jiang, Hui; Xing, Guo-Gang

doi:10.7150/thno.51869

Cited by 32 publications

(19 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EA also markedly increased expression of vimentin and α-tubulin in Sertoli cells, significantly enhanced the immunoreactivity of proliferating cell nuclear antigen, and decreased apoptosis in germ cells. Finally, in a recent study, again by Jin et al [23], using a rat model of idiopathic asthenozoospermia, the therapeutic effects of electro-acupuncture were reported. Transcutaneous electrical acupoint stimulation (TEAS) and electro-acupuncture (EA) at the traditional acupuncture points of BL-23, ST-36, CV-1, and CV-4 were used.…”

Section: Influence Directed On the Gonadsmentioning

confidence: 86%

Evidence-Based Application of Acupuncture in Theriogenology

Holyoak

2022

Veterinary Sciences

View full text Add to dashboard Cite

Historical evidence of acupuncture predates written history. It has been a component of Traditional Chinese veterinary medicine for many generations and is officially recognized in recorded history for treating equine disease in the Zhou Dynasty, circa 1050 BC. Drawing from a range of searchable databases, we present the use of veterinary acupuncture related to theriogenology. We touch on human-based medicine only as an introduction to current uses within veterinary medical acupuncture. This review is confined to the use of acupuncture encompassing dry needle, electroacupuncture, aquapuncture, and the few reports of laserpuncture. Starting with acupuncture’s influence on the master organs of reproduction, the hypothalamus and the pituitary glands, and the hypothalamic–pituitary–gonadal axis, we then review reports specific to the gonads—ovaries and testicles—and then its influences on the uterus. From there, we review reports on the influence of acupuncture on pain associated with reproductive surgery, and finally, on the use of acupuncture for maternal lactation. Based on published reports, we conclude that acupuncture has been shown to be effective in many situations as a treatment for infertility and/or reproductive tract disfunction, resulting in improvements in both female and male patients.

show abstract

Section: Influence Directed On the Gonadsmentioning

confidence: 86%

Evidence-Based Application of Acupuncture in Theriogenology

Holyoak

2022

Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…Cauda epididymal sperm of rats were collected immediately after euthanasia and prepared as described in a previous article [ 25 ]. In brief, two caudal epididymides were placed in 2 ml preheated phosphate buffer saline (PBS), slightly cut into three pieces and incubated for 5 min at 37°C in a 5% CO 2 incubator.…”

Section: Methodsmentioning

confidence: 99%

Therapeutic Effects of Xianlu Oral Solution on Rats with Oligoasthenozoospermia through Alleviating Apoptosis and Oxidative Stress

Jin

Cao

Luo

et al. 2022

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

Idiopathic oligoasthenozoospermia (iOAZS) is one of the major causes of male infertility, and the ideal therapies for iOAZS have not been established yet. Traditional Chinese medicine (TCM), including Xianlu oral solution (XL), has been widely used as an adjunct treatment for male infertility in the clinic. However, the underlying mechanisms of XL treatment on iOAZS are still not known. Here, we found that XL treatment has therapeutic effects on ornidazole (ORN)-induced OAZS model rats through the amelioration of testis tissues spermatogenesis and the improvement of sperm concentration and motility. Moreover, XL treatment ameliorated the serum hormone levels, mitochondrial membrane potential, apoptosis status, and oxidative stress status in the testis tissues of iOAZS model rats. These findings identify a potential mechanism underlying the therapeutic effects of Xianlu oral solution on iOAZS, and Xianlu oral solution may be used as a traditional Chinese medicine (TCM) therapy for male infertility caused by iOAZS in clinical practice.

show abstract

“…found a novel mechanism for the pathogenesis of asthenozoospermia. The downregulation of CatSper channel in the sperm might be a contributor or a downstream indicator for asthenozoospermia, while 2 Hz TEAS or EA can be beneficial to recover through inducing the functional upregulation of CatSper channels in the sperm ( 74 ).…”

Section: Clinical Effect and Mechanism Of Acupuncture On Male Inferti...mentioning

confidence: 99%

The efficacy and mechanism of acupuncture in the treatment of male infertility: A literature review

Feng

He²,

Wang³

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

Fertility, a social, cultural, and medical issue, has aroused public attention because of its potential to predict future health. In recent years, the incidence of male infertility has increased significantly, and various risk factors, such as congenital factors, acquired factors, and idiopathic factors, have led to this situation. Male infertility causes substantial psychological and social distress in patients. With the implementation of the two-child policy, male infertility has brought enormous psychological and social pressure and huge economic burden to patients and the healthcare system. This has attracted the attention of not only men of childbearing age but also many male experts. The conventional therapeutic approaches for treating male infertility, including drugs, varicocele surgery, intrauterine insemination, in vitro fertilization, and intracytoplasmic sperm injection, can restore fertility to a certain extent, but their efficacy is far from satisfactory, not to mention some adverse events. Therefore, acupuncture has been chosen by many men to treat their infertility and produced significant effects. In the present paper, the efficacy and mechanism of acupuncture in the treatment of male infertility were analyzed from different perspectives such as regulating hormone secretion, reducing inflammation, and improving semen parameters. The existing literature shows that acupuncture can effectively treat male infertility.

show abstract

Roles of CatSper channels in the pathogenesis of asthenozoospermia and the therapeutic effects of acupuncture-like treatment on asthenozoospermia

Cited by 32 publications

References 75 publications

Evidence-Based Application of Acupuncture in Theriogenology

Evidence-Based Application of Acupuncture in Theriogenology

Therapeutic Effects of Xianlu Oral Solution on Rats with Oligoasthenozoospermia through Alleviating Apoptosis and Oxidative Stress

The efficacy and mechanism of acupuncture in the treatment of male infertility: A literature review

Contact Info

Product

Resources

About