Roles of CD147 on T lymphocytes activation and MMP‐9 secretion in Systemic Lupus Erythematosus

Pistol, Gina Cecilia; Matache, Cristiana; Călugăru, A; Stăvaru, Crina; Tănăseanu, S; Ionescu, Ruxandra; Dumitrache, Sergiu; Stefănescu, M

doi:10.1111/j.1582-4934.2007.00022.x

Cited by 39 publications

(40 citation statements)

References 39 publications

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“…Analysis of mRNA levels in both naïve and activated T cells revealed a 3.75-fold increase in CD147 transcription in the activated population (Zhang et al 2002). Recently, increased expression of CD147 was observed on CD3+ T cells from systemic lupus erythematosus patients compared to healthy donor T cells, likely indicating their increased activation (Pistol et al 2007). Engagement of CD147 with the MEM-M6/6 anti-CD147 monoclonal antibody was found to inhibit anti-CD3 induced T cell activation (Koch et al 1999), presumably by inhibiting the reorganization and clustering of GPI-anchored coreceptors within lipid rafts which in turn alters down-stream signaling events (Staffler et al 2003).…”

Section: Role In Lymphocyte Migration and Activationmentioning

confidence: 96%

CD147 immunoglobulin superfamily receptor function and role in pathology

Iacono

Brown

Greene

et al. 2007

Experimental and Molecular Pathology

243

206

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The immunoglobulin superfamily member CD147 plays an important role in fetal, neuronal, lymphocyte and extracellular matrix development. Here we review the current understanding of CD147 expression and protein interactions with regard to CD147 function and its role in pathologic conditions including heart disease, Alzheimer's disease, stroke and cancer. A model linking hypoxic conditions found within the tumor microenvironment to up-regulation of CD147 expression and tumor progression is introduced.

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Section: Role In Lymphocyte Migration and Activationmentioning

confidence: 96%

CD147 immunoglobulin superfamily receptor function and role in pathology

Iacono

Brown

Greene

et al. 2007

Experimental and Molecular Pathology

243

206

View full text Add to dashboard Cite

show abstract

“…Among the immune-response genes, TNFRSF8 and BSG attracted our interest because these genes were upregulated in the PP samples (Fig. 3A) and encode the activation markers CD30 and CD147, which have been associated with regulatory T cells (14,15), Th2-like response, and chronic T-cell stimulation (16,17), although these genes are also detected in other immune cell subsets (18). In addition, TNFRSF8 upregulation was associated with several downregulated genes in the "inflammatory response, cell death and cell-mediated immune response" IPA pathway network shown in Fig.…”

Section: Validation Studies Confirm Differential Gene Expression Pattmentioning

confidence: 99%

Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome and Reveal an Association of CD30+ T Lymphocytes with Progression

et al. 2014

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Sentinel lymph nodes set the stance of the immune system to a localized tumor and are often the first site to be colonized by neoplastic cells that metastasize. To investigate how the presence of neoplastic cells in sentinel lymph nodes may trigger pathways associated with metastatic progression, we analyzed the transcriptional profiles of archival sentinel node biopsy specimens obtained from melanoma patients. Biopsies from positive nodes were selected for comparable tumor infiltration, presence or absence of further regional node metastases, and relapse at 5-year follow-up. Unsupervised analysis of gene expression profiles revealed immune response to be a major gene ontogeny represented. Among genes upregulated in patients with progressing disease, the TNF receptor family member CD30/TNFRSF8 was confirmed in biopsy specimens from an independent group of patients. Immunohistochemical analysis revealed higher numbers of CD30 þ lymphocytes in nodes from progressing patients compared with nonprogressing patients. Phenotypic profiling demonstrated that CD30 þ lymphocytes comprised a broad population of suppressive or exhausted immune cells, such as CD4 þ Foxp3 þ or PD1 þ subpopulations and CD4 À CD8 À T cells. CD30 þ T lymphocytes were increased in peripheral blood lymphocytes of melanoma patients at advanced disease stages. Our findings reinforce the concept that sentinel nodes act as pivotal sites for determining progression patterns, revealing that the presence of CD30 þ lymphocytes at those sites associate positively with melanoma progression. Cancer Res; 74(1); 130-40. Ó2014 AACR.

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“…Studies carried out using CD147 Ϫ/Ϫ cells have also shown that the absence of this protein leads to hyperproliferation of T-cells during mixed lymphocyte reactions (25). Finally, it has been reported that CD147 receptor cross-linking also contributes to diminished responses by T-cells in systemic lupus erythematosus (13) and to a developmental block of thymocytes (33).…”

mentioning

confidence: 99%

“…Furthermore, based on its high expression levels, it has been proposed that its expression status can be used as a prognostic factor in different tumors (1)(2)(3)(4). CD147 overexpression and/or function has been associated with other pathological processes such as inflammatory responses (6,7), pulmonary fibrosis (8), rheumatoid arthritis (9 -12), systemic lupus erythematosus (13), heart failure (14), Alzheimer disease (15), and the infectivity cycle of the human immunodeficiency virus and coronaviruses in lymphocytes (16,17).…”

mentioning

confidence: 99%

CD147 Inhibits the Nuclear Factor of Activated T-cells by Impairing Vav1 and Rac1 Downstream Signaling

Ruíz¹,

Castro-Castro²,

Bustelo

2008

Journal of Biological Chemistry

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CD147 is a transmembrane protein that plays crucial roles in the development and function of the reproductive, visual, and nervous systems. CD147 also exerts positive and negative actions in T-cells by still obscure mechanisms. In this study, we have analyzed the expression, localization, and function of CD147 during T-cell receptor signaling responses. We show here that CD147 is an integral component of the T-cell immune synapse and that its overexpression leads to the inhibition of NF-AT (nuclear factor of activated T-cells) activity induced by Vav1, a Rac1 exchange factor. This inhibitory activity is mediated by the CD147 intracellular tail and is totally independent of its extracellular or transmembrane regions. The molecular dissection of the influence of CD147 on the Vav1 pathway indicates that its inhibitory action takes place downstream of Vav1 and Rac1 but upstream of the serine/threonine kinases JNK and Pak1. The interference of CD147 with these pathways is highly specific because the overexpression of CD147 does not affect the activity of other GDP/GTP exchange factors or the stimulation of the ERK cascade. Finally, we show that the CD147 knockdown in Jurkat cells promotes higher levels of NF-AT stimulation and Pak1 phosphorylation upon T-cell receptor cross-linking. Instead, the lack of CD147 does not affect other signaling cascades that participate in the same cellular response. Taken together, these results indicate that CD147, via the selective inhibition of specific downstream elements of the Vav1/Rac1 route, contributes to the negative regulation of T-cell responses.

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Roles of CD147 on T lymphocytes activation and MMP‐9 secretion in Systemic Lupus Erythematosus

Cited by 39 publications

References 39 publications

CD147 immunoglobulin superfamily receptor function and role in pathology

CD147 immunoglobulin superfamily receptor function and role in pathology

Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome and Reveal an Association of CD30+ T Lymphocytes with Progression

CD147 Inhibits the Nuclear Factor of Activated T-cells by Impairing Vav1 and Rac1 Downstream Signaling

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