Roles of circRNAs in prostate cancer: Expression, mechanism, application and potential

Zhang, Chunlei; Yang, Qi; Li, Weiping; Kang, Yindong; Zhou, Fenghai; Chang, D.

doi:10.1016/j.biocel.2021.105968

Cited by 9 publications

(5 citation statements)

References 88 publications

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“…There is emerging evidence of the role of circRNA in multiple cancers, including PCa [ 25 , 26 ]. The present study showed that circGFRA1 was upregulated in PCa tumor tissues compared to normal tissues.…”

Section: Discussionmentioning

confidence: 99%

LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer

Meng

2022

Journal of Immunology Research

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Prostate cancer (PCa) is the most common cancer affecting men, with increasing global mortality and morbidity rates. Despite the progress in the diagnosis and treatment of PCa, patient outcomes remain poor, and novel therapeutic targets for PCa are urgently needed. Recently, circular RNAs (circRNAs) have been studied in-depth as potential biomarkers for many diseases. In this study, circRNA microarrays using four pairs of PCa tissues were utilized to show that circGFRA1 was upregulated in PCa tumor tissues. CircGFRA1 is suggested to play an oncogene role in PCa progression as the silencing of circGFRA1 inhibited the proliferation, migration, and immune escape activity of PCa cells. Furthermore, by utilizing bioinformatics analysis, RIP, RNA pull-down, and luciferase reporter assays, our results showed that LMX1B could bind to the GFRA1 promoter and regulate circGFRA1 expression in PCa cells and circGFRA1 upregulated HECTD1 expression through sponging miR-3064-5p. This novel LMX1B/circGFRA1/miR-3064-5p/HECTD1 axis identified in PCa provides new insights for developing novel therapeutic strategies for PCa.

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Section: Discussionmentioning

confidence: 99%

LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer

Meng

2022

Journal of Immunology Research

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“…Lastly, circRNAs are circular molecules formed by transsplicing, which are highly stable and can be detected in body fluids. They are involved in many important molecular regulatory mechanisms ( 44 ), and may have unique advantages in diagnosis, treatment, monitoring, and prognosis. Studies have found a role of circRNA in the onset and progression of PCa.…”

Section: Introductionmentioning

confidence: 99%

The regulatory process and practical significance of non-coding RNA in the dissemination of prostate cancer to the skeletal system

Sang,

Li,

Zhao

et al. 2024

Front. Oncol.

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Prostate cancer is a major contributor to male cancer-related mortality globally. It has a particular affinity for the skeletal system with metastasis to bones seriously impacting prognosis. The identification of prostate cancer biomarkers can significantly enhance diagnosis and patient monitoring. Research has found that cancer and metastases exhibit abnormal expression of numerous non-coding RNA. Some of these RNA facilitate prostate cancer bone metastasis by activating downstream signaling pathways, while others inhibit this process. Elucidating the functional processes of non-coding RNA in prostate cancer bone metastasis will likely lead to innovative treatment strategies for this malignant condition. In this review, the mechanistic role of the various RNA in prostate cancer is examined. Our goal is to provide a new avenue of approach to the diagnosis and treatment of bone metastasis in this cancer.

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“…Several oncological studies reported that circRNAs played crucial roles in tumor progression and the development of chemotherapeutic resistance [ 8 , 9 ]. Besides, the deregulation of circRNAs is also implicated in the diagnosis and prognosis of PCa [ 10 ]. For instance, circABCC4 was reported as a competitive endogenous RNA (ceRNA) of miR-1182 and its overexpression promotes the growth of PCa cells by upregulating Forkhead Box P4 (FOXP4) expression [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

CircTHSD4 promotes the malignancy and docetaxel (DTX) resistance in prostate cancer by regulating miR-203/HMGA2 axis

XIE,

LU,

ZHANG

et al. 2024

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Objective Circular ribose nucleic acids (circRNAs) are implicated in tumor progression and drug resistance of prostate cancer (PCa). The current work explored the function of circ_0005203 (circTHSD4) in the malignancy and docetaxel (DTX) resistance of PCa. Methods circTHSD4 expression within PCa as well as matched non-carcinoma samples was measured through real-time reverse transcription-quantitative polymerase chain reaction (RT-qPCR). In addition, a subcellular fraction assay was conducted to determine circTHSD4 subcellular localization within PCa cells. In addition, we performed a Western blot (WB) assay to detect high-mobility-group A2 protein (HMGA2) levels. Besides, functional associations of two molecules were investigated through dual luciferase reporter assay. Cell Counting Kit (CCK)-8, colony formation together with Transwell assay was conducted to assess malignant phenotypes of PCa cells, whereas flow cytometry was performed to determine cell apoptosis. Furthermore, a xenograft mouse model was constructed to verify the effect of circTHSD4 on the carcinogenesis of PCa cells. Results According to RT-qPCR results, circTHSD4 was up-regulated within PCa tissues and cells, which predicted the dismal prognostic outcome of PCa cases. circTHSD4 silencing within PCa cells markedly suppressed cell growth, migration, and colony formation. circTHSD4 silencing remarkably elevated PCa cell apoptosis and carcinogenesis within the xenograft model. Further, circTHSD4 silencing enhanced docetaxel (DTX) sensitivity in PCa cells. Furthermore, we demonstrated that circTHSD4 modulated the malignancy of PCa cells by regulating HMGA2 expression through sponging miR-203. Conclusion Together, our findings suggest that circTHSD4 overexpression could promote the malignant phenotype and DTX resistance in PCa through the regulation of the miR-203/HMGA2 axis.

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Roles of circRNAs in prostate cancer: Expression, mechanism, application and potential

Cited by 9 publications

References 88 publications

LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer

LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer

The regulatory process and practical significance of non-coding RNA in the dissemination of prostate cancer to the skeletal system

CircTHSD4 promotes the malignancy and docetaxel (DTX) resistance in prostate cancer by regulating miR-203/HMGA2 axis

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