Roles of Coffee and Its Components in Liver Diseases

Abstract

Coffee is a widely consumed beverage with multifaceted health benefits. While several studies have explored its effects on various diseases, limited reports have investigated its association with liver disease. Therefore, this review aimed to explore the effects of coffee consumption and its major coffee components on liver disease. Meta-analysis results have suggested that coffee consumption may reduce the risk of non-alcoholic fatty liver disease, hepatic fibrosis, and hepatocellular carcinoma, but the molecular mechanisms underlying these beneficial actions of coffee consumption remain elusive. Studying the individual components of coffee could help us better understand the mechanisms behind its liver protective effects. To clarify a more precise mechanism of coffee-related liver protective effects, the experimentally determined effects of each coffee component on liver diseases are also reviewed.