Roles of corticosterone in formalin-induced conditioned place aversion in rats

Wang, Han-Cheng; Wang, Ying-Chou; Huang, Andrew Chih Wei; Chai, Sin-Chee; Wu, Yi-No; Wang, Chia–Chuan

doi:10.1016/j.neulet.2009.08.053

Cited by 10 publications

(11 citation statements)

References 33 publications

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“…Specifically, CPA could be elicited in rats by i.p. administration of AA or intraplantar administration of complete Freund’s adjuvant, formalin, or carrageenan (Deyama et al, 2007; Johansen et al, 2001; LaBuda and Fuchs, 2000; Tanimoto et al, 2003; van der Kam et al, 2008; Wang et al, 2009). In this study, we used a CPA procedure to investigate the affective component of pain in mice.…”

Section: Discussionmentioning

confidence: 99%

Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice

et al. 2016

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Pain encompasses both a sensory as well as an affective dimension and these are differentially processed in the brain and periphery. It is therefore important to develop animal models to reflect the non-reflexive assays in pain. In this study, we compared effects of the mu opioid receptor agonist morphine, the nonsteroidal anti-inflammatory drug ketoprofen and the kappa receptor opioid agonist U50,488H and antagonist JDTic on acetic acid-induced stretching and acetic acid-induced aversion in the condition place aversion (CPA) test in male ICR mice. Intraperitoneal administration of acetic acid (0.32–1%) was equipotent in stimulating stretching and CPA. Ketoprofen, morphine and U50,488H all inhibited the acid-induced stretching. Ketoprofen and morphine also blocked the acid-induced CPA but U50,488H failed to do so. The reversal ability of ketoprofen and morphine on acid-induced CPA is unique to pain-stimulated place aversion since these drugs failed to reduce non-noxious LiCl-induced CPA. Overall, this study characterized and validated a preclinical mouse model of pain-related aversive behavior that can be used to assess genetic and biological mechanisms of pain as well as improving the predictive validity of preclinical studies on candidate analgesics.

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Section: Discussionmentioning

confidence: 99%

Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice

et al. 2016

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“…Similarly, daily rises in acetylcholine levels associated with task performance have been shown to become anticipatory and time-locked when training occurs at the same time every day, and this precise daily increase in acetylcholine persists for several days in the absence of cognitive training (Paolone et al, 2012). The implementation of a foot-shock in our TPL paradigm likely attributes additional systems related to fear processing (emotional content) and risk evaluation (Amir & Stewart, 2009; Lansink et al, 2012; McIntyre et al, 2012; Roozendaal et al, 2008; Wang et al, 2009). …”

Section: Discussionmentioning

confidence: 99%

“…In line with this, SCNx mice in the current study showed intact food anticipatory activity (FAA), although it should be mentioned that FAA measured in this study is likely influenced by the testing procedures. Extensive evidence indicates that stress hormones released from the adrenal glands are critically involved in memory consolidation of emotionally arousing experience by amygdala activation (Amir & Stewart, 2009; McIntyre et al, 2012; Wang et al, 2009; Roozendaal et al, 2008). Moreover, the rhythmic expression of Per1 in the dentate gyrus was found to be suppressed by corticosterone (Gilhooley et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Neither the SCN nor the adrenals are required for circadian time-place learning in mice

Mulder

Papantoniou²,

Gerkema

et al. 2014

Chronobiology International

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During Time-Place Learning (TPL), animals link biological significant events (e.g. encountering predators, food, mates) with the location and time of occurrence in the environment. This allows animals to anticipate which locations to visit or avoid based on previous experience and knowledge of the current time of day. The TPL task applied in this study consists of three daily sessions in a three-arm maze, with a food reward at the end of each arm. During each session, mice should avoid one specific arm to avoid a foot-shock. We previously demonstrated that, rather than using external cue-based strategies, mice use an internal clock (circadian strategy) for TPL, referred to as circadian TPL (cTPL). It is unknown in which brain region(s) or peripheral organ(s) the consulted clock underlying cTPL resides. Three candidates were examined in this study: (a) the suprachiasmatic nucleus (SCN), a light entrainable oscillator (LEO) and considered the master circadian clock in the brain, (b) the food entrainable oscillator (FEO), entrained by restricted food availability, and (c) the adrenal glands, harboring an important peripheral oscillator. cTPL performance should be affected if the underlying oscillator system is abruptly phase-shifted. Therefore, we first investigated cTPL sensitivity to abrupt light and food shifts. Next we investigated cTPL in SCN-lesioned- and adrenalectomized mice. Abrupt FEO phase-shifts (induced by advancing and delaying feeding time) affected TPL performance in specific test sessions while a LEO phase-shift (induced by a light pulse) more severely affected TPL performance in all three daily test sessions. SCN-lesioned mice showed no TPL deficiencies compared to SHAM-lesioned mice. Moreover, both SHAM- and SCN-lesioned mice showed unaffected cTPL performance when re-tested after bilateral adrenalectomy. We conclude that, although cTPL is sensitive to timing manipulations with light as well as food, neither the SCN nor the adrenals are required for cTPL in mice.

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“…There is a significant co-morbidity between chronic pain and various anxiety and depressive disorders in people [75], and animal studies have shown that noxious stimuli, including formalin and CFA, stimulate behavioural, limbic and neuroendocrine activity characteristic of stress and depression [76–79]. Indeed, the effects of CFA on hippocampal neurogenesis described above can be abolished by anti-depressants [80].…”

Section: Discussionmentioning

confidence: 99%

Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat

Johnston

Maier

Rudy

et al. 2012

Behavioural Brain Research

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There is evidence that pain can impact cognitive function in people. The present study evaluated whether Pavlovian fear conditioning in rats would be reduced if conditioning were followed by persistent inflammatory pain induced by a subcutaneous injection of dilute formalin or complete Freund's adjuvant (CFA) on the dorsal lumbar surface of the back. Formalin-induced pain specifically impaired contextual fear conditioning but not auditory cue conditioning (Experiment 1A). Moreover, formalin pain only impaired contextual fear conditioning if it was initiated within 1 h of conditioning and did not have a significant effect if initiated 2, 8 or 32 h after (Experiments 1A and 1B). Experiment 2 showed that formalin pain initiated after a session of context pre-exposure reduced the ability of that pre-exposure to facilitate contextual fear when the rat was limited to a brief exposure to the context during conditioning. Similar impairments in context- but not CS-fear conditioning were also observed if the rats received an immediate post-conditioning injection with CFA (Experiment 3). Finally, we confirmed that formalin and CFA injected s.c. on the back induced pain-indicative behaviours, hyperalgesia and allodynia with a similar timecourse to intraplantar injections (Experiment 4). These results suggest that persistent pain impairs learning in a hippocampus-dependent task, and may disrupt processes that encode experiences into long-term memory.

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Roles of corticosterone in formalin-induced conditioned place aversion in rats

Cited by 10 publications

References 33 publications

Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice

Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice

Neither the SCN nor the adrenals are required for circadian time-place learning in mice

Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat

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