Roles of different n-3/n-6 PUFA ratios in ovarian cell development and steroidogenesis in PCOS rats

Ma, Xiaoshu; Weng, Xuechun; Hu, Xusong; Wang, Qiaozhi; Tian, Ye; Ding, Yu; Zhang, Cheng

doi:10.1039/c9fo01730e

Cited by 11 publications

(6 citation statements)

References 52 publications

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“…hs-CRP is a biochemical marker produced in response to stimulation by IL, such as IL-6 (43) , which can be downregulated by EPA and DHA (38,39) . With regard to serum n-3 PUFA, we found that the levels of LH decreased as the levels of total, certain long-chain n-3 PUFA, EPA, DPA and DHA increased, while the levels of FSH and SHBG increased when all the serum n-3 PUFA mentioned above increased, except for ALA. PUFA may induce elevated serum FSH due to the upregulated expression of cytochrome P450 lanosterol 14a-demethylase (CYP51), a critical enzyme that converts lanosterol into cholesterol, in granulosa cells (44,45) .…”

Section: Discussionmentioning

confidence: 99%

Dietary and serum n-3 PUFA and polycystic ovary syndrome: a matched case–control study

et al. 2021

Br J Nutr

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The results of epidemiological studies involving omega-3 polyunsaturated fatty acids (PUFAs) and polycystic ovary syndrome (PCOS) are scarce. This matched case-control study assessed the associations between omega-3 PUFAs and PCOS prevalence in 325 pairs of PCOS cases and healthy controls. Dietary information was assessed using a 102-item food frequency questionnaire. Fatty acids in serum phospholipids were measured with a gas chromatography method. We found that omega-3 PUFAs in serum phospholipids were inversely associated with PCOS prevalence, including total, long-chain and individual PUFAs (e.g., docosapentaenoic acid (DPA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)). Compared to the lowest tertile (T1), the adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) for the highest tertile (T3) were 0.63 (0.40, 0.93) for total omega-3 PUFAs, 0.60 (0.38, 0.92) for long-chain omega-3 PUFAs, 0.68 (0.45, 1.01) for DHA, 0.70 (0.45, 1.05) for EPA and 0.72 (0.45, 1.08) for DPA. For dietary intake of omega-3 PUFAs, significant inverse associations were found only for long-chain omega-3 PUFAs (p trend = 0.001), EPA (p trend = 0.047) and DHA (p trend = 0.030). Both dietary and serum omega-3 PUFAs, mainly EPA and DPA, were negatively correlated with PCOS-related parameters, such as BMI, fasting insulin, total testosterone and high-sensitivity C-reactive protein (hs-CRP), but positively correlated with follicle-stimulating hormone (FSH) and sex hormone-binding globulin (SHBG). These results indicated inverse associations between omega-3 PUFAs, especially long-chain omega-3 PUFAs, and PCOS prevalence. Higher intakes of omega-3 PUFAs might be considered a protective factor for PCOS among Chinese females.

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Section: Discussionmentioning

confidence: 99%

Dietary and serum n-3 PUFA and polycystic ovary syndrome: a matched case–control study

et al. 2021

Br J Nutr

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“…Early studies have confirmed the reliability of metabolic changes in assessing oocyte quality and studying ovarian diseases. 9,10 We therefore analysed the fecal metabolic profiles using UHPLC-Q-TOF-MS/MS. The results of the partial least squares discriminant analysis (PLS-DA) score plot showed that the quality control samples were well clustered in both positive and negative ion modes (Fig.…”

Section: Effects Of Lbp Supplementation On the Fecal Metabolite Profi...mentioning

confidence: 99%

“…7 Studies have shown that a variety of metabolites, including lipids, glycerophospholipids, steroids and amino acids, are altered in POI patients. 8 Early studies have confirmed the reliability of metabolic changes in assessing oocyte quality and studying ovarian diseases, 9,10 suggesting that metabolic changes may provide a suitable strategy for POI research.…”

Section: Introductionmentioning

confidence: 99%

Integrated gut microbiota and fecal metabolome analyses of the effect ofLycium barbarumpolysaccharide ond-galactose-induced premature ovarian insufficiency

et al. 2023

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“…However, with the balanced diet, supplementation can be regarded as a seasonal intervention [ 112 ]. Polyunsaturated fatty acids (PUFAs) enhance the reproductive performance in PCOS by increasing the expression of steroidogenesis enzymes, which are related to hormone secretion and ovarian functions, and the protein levels of CYP51, CYP19, StAR, and 3β-HSD [ 113 ]. In summary, supplementing the diet is an individual subject that requires dietary consultation with the patient, and its active participation and compliance is desirable for the overall improvement of the metabolic equilibrium.…”

Section: Lifestyle Changesmentioning

confidence: 99%

Nutrition Strategy and Life Style in Polycystic Ovary Syndrome—Narrative Review

et al. 2021

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Here we present an extensive narrative review of the broadly understood modifications to the lifestyles of women with polycystic ovary syndrome (PCOS). The PubMed database was analyzed, combining PCOS entries with causes, diseases, diet supplementation, lifestyle, physical activity, and use of herbs. The metabolic pathways leading to disturbances in lipid, carbohydrate, and hormonal metabolism in targeted patients are described. The article refers to sleep disorders, changes in mental health parameters, and causes of oxidative stress and inflammation. These conditions consistently lead to the occurrence of severe diseases in patients suffering from diabetes, the fatty degeneration of internal organs, infertility, atherosclerosis, cardiovascular diseases, dysbiosis, and cancer. The modification of lifestyles, diet patterns and proper selection of nutrients, pharmacological and natural supplementation in the form of herbs, and physical activity have been proposed. The progress and consequences of PCOS are largely modifiable and depend on the patient’s approach, although we have to take into account also the genetic determinants.

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Roles of different n-3/n-6 PUFA ratios in ovarian cell development and steroidogenesis in PCOS rats

Abstract: Polycystic ovary syndrome (PCOS) is a complex and common endocrine disorder characterized by hyperandrogenism, which is accompanied by follicle growth arrest at the small antral stage, minimal granulosa cell proliferation, and chronic anovulation.

Cited by 11 publications

References 52 publications

Dietary and serum n-3 PUFA and polycystic ovary syndrome: a matched case–control study

Dietary and serum n-3 PUFA and polycystic ovary syndrome: a matched case–control study

Integrated gut microbiota and fecal metabolome analyses of the effect ofLycium barbarumpolysaccharide ond-galactose-induced premature ovarian insufficiency

Nutrition Strategy and Life Style in Polycystic Ovary Syndrome—Narrative Review

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