Roles of Exosomes and Exosomal MicroRNAs in Postoperative Sleep Disturbance

Gu, Xiangyi; Zhu, Junchao

doi:10.2147/nss.s310351

Cited by 7 publications

(5 citation statements)

References 120 publications

(137 reference statements)

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“…[ 27 – 29 ] Besides, recent research has shown that changes in miRNA expression exert a certain effect on the biological mechanism of POCD. [ 30 , 31 ] More importantly, we show that LncRNA GAS5 suppressed miR-137 in vitro model. Gao et al reported that GAS5 is up-regulated in knee osteoarthritis, and can induce chondrocyte apoptosis through down-regulating miR-137.…”

Section: Discussionmentioning

confidence: 67%

Effects of LncRNA GAS5/miR-137 general anesthesia on cognitive function by TCF4 inflammatory bodies in patients undergoing lumbar spinal canal decompression

Zhang

Chen

et al. 2022

Medicine

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Lumbar spinal stenosis is a common orthopedic disease in clinical practice at present. Postoperative cognitive dysfunction (POCD) refers to the phenomenon of impaired memory. However, whether long noncoding RNA (LncRNA) GAS5 contributes to the mechanism of cognitive function in undergoing lumbar spinal canal decompression remains unknown. Thus, the present study investigated the precise details of LncRNA GAS5 involvement in Postoperative cognitive dysfunction of patients undergoing lumbar spinal canal decompression. Patients undergoing lumbar spinal canal decompression with cognitive function and Normal healthy volunteers were obtained. C57BL/6 mice were maintained with a 2% concentration of sevoflurane in 100% oxygen at a flow rate of 2 L minute-1 for 4 hours. LncRNA GAS5 gene expression were up-regulated in patients undergoing lumbar spinal canal decompression. In mice model, LncRNA GAS5 gene expression also increased. LncRNA GAS5 promoted neuroinflammation in vitro model. LncRNA GAS5 raised cognitive impairment and increased neuroinflammation in mice model. LncRNA GAS5 suppressed miR-137 in vitro model. MiR-137 reduced neuroinflammation in vitro model. MiR-137 suppressed TCF4 protein expression in vitro model. Transcription factor TCF4 activates the expression of bHLH. Taking together, this experiment provide the first experimental and clinical evidence that LncRNA GAS5/miR-137 promoted anesthesia-induced cognitive function to increase inflammatory bodies in patients undergoing lumbar spinal canal decompression, suggesting it may be a biomarker of POCD and a potential therapeutic target for POCD.

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Section: Discussionmentioning

confidence: 67%

Effects of LncRNA GAS5/miR-137 general anesthesia on cognitive function by TCF4 inflammatory bodies in patients undergoing lumbar spinal canal decompression

Zhang

Chen

et al. 2022

Medicine

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“…There is growing evidence that exosomes may also have a positive impact on neurodegenerative diseases, although some studies showed that exosomes are harmful and may to neurodegenerative diseases [ 47 , 48 ]. We found that miR-184 ASO could rescue the damaged of motor performance and neuronal apoptosis in PD model.…”

Section: Discussionmentioning

confidence: 99%

MiR-184 Mediated the Expression of ZNF865 in Exosome to Promote Procession in the PD Model

Liu,

Wang,

et al. 2023

Mol Neurobiol

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Exosomes are nanoscale small vesicles (EVs) secreted by cells that carry important bio information, including proteins, miRNAs, and more. Exosome contents are readily present in body fluids, including blood, and urine of humans and animals, and thereby act as markers of diseases. In patients with Parkinson’s disease (PD), exosomes may spread alpha-synuclein and miR-184 between the cells contributing to dopaminergic neuronal loss. In this study, we detected the levels of miR-184 in urine-excreted neuronal exosomes between PD patients and age-matched healthy subjects by qRT-PCR analysis. Transmission electron microscopy (TEM) and nanoparticle tracking analysis (NTA) were also used to determine the ultracellular structures of exosomes nanoparticles. MPP + and MPTP were used to construct the cell and animal PD model. Behavioral tests were used to detect motor performance. Furthermore, the cytological experiments were measured to examine the relationship between miR-184 and ZNF865. We found that the levels of miR-184 in urine-derived neuronal exosomes from PD patients were higher, compared to aged-matched normal people. The exosomes from PD patients were larger with greater numbers than those from the age-matched healthy subjects. The difference in miR-184 in urinary exosomes between PD patients and normal people may provide a novel perspective for early diagnosis of PD. However, no difference in CD63 level was observed in Exo-control and Exo-PD groups (exosome from control or PD groups). Moreover, ZNF865 was detected as the targeted gene of miR-184. In addition, miR-184 ASO (miR-184 antisense oligodeoxynucleotide, miR-184 ASO) could rescue the damage of neuronal apoptosis and motor performance in PD mice. Our results showed the miR-184 potential to function as a diagnostic marker of PD. Graphical Abstract

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“…Treatments based on LINGO-1 (LRR and Ig domain containing NOGO receptor interacting protein) antagonism and protein kinase B (Akt) activation in experimental models of cognitive loss in MS may assist to maintain memory function through the promotion of oligodendrocyte differentiation and myelination [145]. Mood disorders that include depression, apathy, and anxiety can accompany the cognitive loss in MS similar to presentations seen in AD [99,[146][147][148][149][150][151]. The cognitive impairment in MS patients also may play a significant role in preventing individuals from returning to prior levels of functioning and the workforce [152].…”

Section: Cognitive Loss and Dementia That Can Occur In Multiple Scler...mentioning

confidence: 99%

Cognitive Impairment in Multiple Sclerosis

Maiese

2023

Bioengineering

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Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a demyelinating disease in the nervous system with increased prevalence over the last five decades, and is now being recognized as one significant etiology of cognitive loss and dementia. Presently, disease modifying therapies can limit the rate of relapse and potentially reduce brain volume loss in patients with MS, but unfortunately cannot prevent disease progression or the onset of cognitive disability. Innovative strategies are therefore required to address areas of inflammation, immune cell activation, and cell survival that involve novel pathways of programmed cell death, mammalian forkhead transcription factors (FoxOs), the mechanistic target of rapamycin (mTOR), AMP activated protein kinase (AMPK), the silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1), and associated pathways with the apolipoprotein E (APOE-ε4) gene and severe acute respiratory syndrome coronavirus (SARS-CoV-2). These pathways are intertwined at multiple levels and can involve metabolic oversight with cellular metabolism dependent upon nicotinamide adenine dinucleotide (NAD+). Insight into the mechanisms of these pathways can provide new avenues of discovery for the therapeutic treatment of dementia and loss in cognition that occurs during MS.

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Roles of Exosomes and Exosomal MicroRNAs in Postoperative Sleep Disturbance

Cited by 7 publications

References 120 publications

Effects of LncRNA GAS5/miR-137 general anesthesia on cognitive function by TCF4 inflammatory bodies in patients undergoing lumbar spinal canal decompression

Effects of LncRNA GAS5/miR-137 general anesthesia on cognitive function by TCF4 inflammatory bodies in patients undergoing lumbar spinal canal decompression

MiR-184 Mediated the Expression of ZNF865 in Exosome to Promote Procession in the PD Model

Cognitive Impairment in Multiple Sclerosis

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