Roles of FcγRIIB in Nasal Eosinophilia and IgE Production in Murine Allergic Rhinitis

Watanabe, Tohru; Okano, Mitsuhiro; Hattori, Hiroyuki; Yoshino, Tadashi; Ohno, Naofumi; Ohta, Nobuhiro; Sugata, Yuji; Orita, Yorihisa; Takai, Toshiyuki; Nishizaki, Kazunori

doi:10.1164/rccm.200302-239oc

Cited by 42 publications

(37 citation statements)

References 42 publications

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“…Several studies have shown that intravenous immunoglobulin is also effective in treating refractory asthma, AR, and AD (16)(17)(18). FcγRIIb has been plays a role in nasal eosinophilia in AR (19), and FcγRIIIa gene polymorphisms play a role in the pathogenesis of ITP and atopic disease (20,21). Monoclonal antibodies against FcγRIIIa have been shown to be effective in improving thrombocytopenia in ITP (22,23).…”

Section: Discussionmentioning

confidence: 99%

Association of primary immune thrombocytopenia and common allergic diseases among children

et al. 2015

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Background:Growing evidence has revealed a link between autoimmune and allergic diseases. However, few studies have assessed the relationship between allergic diseases and primary immune thrombocytopenia (ITP), an autoimmune disease frequently occurring in children. This population-based case-control study investigated the association between common allergic diseases and the subsequent risk of developing ITP during childhood. Methods: This study investigated 1,203 children younger than 18 y of age who were diagnosed with ITP between 1998 and 2008, as well as 4,812 frequency-matched controls. The odds ratios of the association between ITP and preexisting allergic diseases were calculated. results: Children with every type of allergic disease examined in this study (except asthma) exhibited an increased risk of developing ITP; the lowest adjusted odds ratio (aOR) was 1.39 for allergic conjunctivitis (95% confidence interval (CI) = 1.09-1.79), whereas the greatest aOR was 1.84 for allergic rhinitis (95% CI = 1.49-2.27). The aORs increased with the number of concurrent allergic diseases to 2.89 (95% CI = 1.98-4.22) for children with at least three allergic diseases. conclusion: Children with atopic diathesis have a greater risk of subsequently developing ITP. The fundamental determinants of this relationship warrant further study.

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Section: Discussionmentioning

confidence: 99%

Association of primary immune thrombocytopenia and common allergic diseases among children

et al. 2015

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“…FcgRIIB deficiency is associated with increased inflammation, allergy, and development of chronic autoimmunity (26,29,30). Moreover, these knockout mice were described to display impaired mucosal tolerance after nasal administration of Ag (OVA), resulting in reduced suppression of eosinophilia and IgE production in murine allergic rhinitis and delayed-type hypersensitivity (DTH) reactions, which was assumed to reflect the lack of FcgRIIB expression on DCs (30,31). The role of FcgRIIB expressed on B cells in oral tolerance has not been examined.…”

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confidence: 99%

Important Role for FcγRIIB on B Lymphocytes for Mucosal Antigen-Induced Tolerance and Foxp3+ Regulatory T Cells

Sun

Zou

Smith³

et al. 2013

The Journal of Immunology

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FcγRIIB, the only FcγR expressed on B cells, is important in the maintenance of immunological tolerance to self-Ags. In this study, we investigated the role of FcγRIIB in Ag-specific CD4 T cell tolerance induced by mucosally administered Ag (OVA) coupled to cholera toxin B subunit (Ag/CTB) or given alone. We found that sublingual administration of Ag/CTB conjugate or intragastric administration of a >100-fold higher dose of Ag alone efficiently suppressed parenteral immunization–induced Ag-specific T cell proliferation and delayed-type hypersensitivity responses in FcγRIIB-expressing wild-type (WT), but not FcγRIIB−/−, mice. Such mucosally induced tolerance (oral tolerance) associated with induction of Ag-specific Foxp3+ regulatory T cells was restored in FcγRIIB−/− mice by adoptive transfer of either WT B cells or WT dendritic cells before the mucosal Ag/CTB treatment; it was even more pronounced in μMT mice that received FcγRIIB-overexpressing B cells before treatment. Furthermore, cell transfer in either WT or μMT mice of WT but not FcγRIIB−/− B cells pretreated for 1 h in vitro with Ag/CTB conjugate induced Ag-specific immunological tolerance, which was further enhanced by adoptive transfer of WT B cells pretreated with anti-Ag IgG immune complexed Ag/CTB. We conclude that FcγRIIB expression on B cells, in addition to dendritic cells, is important for mucosal induction of Ag-specific immune tolerance.

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“…They are also more sensitive to allergic rhinitis [42]. These mice displayed impaired nasal and oral tolerance, suggesting that FcγRIIB are involved in tolerance to air-borne and food allergens.…”

Section: Fcγriibmentioning

confidence: 99%

Regulation of allergy by Fc receptors

Bruhns

Frémont

Daëron

2005

Current Opinion in Immunology

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SummaryThe aggregation of high-affinity IgE receptors (FcεRI) on mast cells and basophils has long been known to be the critical event that initiates allergic reactions. Monomeric IgE was recently found to induce a variety of effects when binding to FcεRI. Up-regulation of FcεRI required binding only, whereas other responses resulted from FcεRI aggregation. Interestingly, FcεRI aggregation has been understood to generate a mixture of positive and negative intracellular signals. Mast cells/basophils express also low-affinity and, under specific conditions, high-affinity IgG receptors. When co-engaging these receptors with FcεRI, IgG antibodies can amplify or dampen IgE-induced mast cell activation. Based on these findings, FcRs have been proposed to be used as targets and/or tools for new therapeutic approaches of allergies.

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Roles of FcγRIIB in Nasal Eosinophilia and IgE Production in Murine Allergic Rhinitis

Cited by 42 publications

References 42 publications

Association of primary immune thrombocytopenia and common allergic diseases among children

Association of primary immune thrombocytopenia and common allergic diseases among children

Important Role for FcγRIIB on B Lymphocytes for Mucosal Antigen-Induced Tolerance and Foxp3+ Regulatory T Cells

Regulation of allergy by Fc receptors

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