2020
DOI: 10.21203/rs.3.rs-95440/v1
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Roles of GABA Signaling in Directing Basket Cell Axonal Projections Toward Purkinje Cells in the Cerebellum

Abstract: Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervous system, synthesized by two isoforms of glutamate decarboxylase (GAD): GAD65 and GAD67. GABA may act as a trophic factor during brain development, but its contribution to the development and maturation of cerebellar neural circuits is not known. To understand the roles of GABA in cerebellar development and associated functions in motor coordination and balance, we examined GAD65 conventional knock out (KO) mice and mice… Show more

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