Roles of GLUT-1 and HK-II expression in the biological behavior of head and neck cancer

Yang, Hang; Zhong, Jiang-Tao; Zhou, Shui‐Hong; Han, He-Ming

doi:10.18632/oncotarget.24684

Cited by 42 publications

(37 citation statements)

References 137 publications

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“…Numerous studies have shown that GLUT-1 overexpression in tumours from different sites can suggest a worse prognosis, such as in colorectal cancer [ 9 ], lung cancer [ 10 ], mesothelioma [ 11 ], head and neck carcinoma [ 12 ], ovarian cancer [ 13 ], urothelial carcinoma [ 14 ], prostate cancer [ 15 ], esophagogastric cancer [ 16 , 17 ] and sarcomas [ 18 ]. The existing data on the prognostic significance of the overexpression of GLUT-1 in pancreatic ductal adenocarcinoma (PDAC) has been limited and not consistent, having increased exponentially in recent years with positive results.…”

Section: Introductionmentioning

confidence: 99%

GLUT-1 as a predictor of worse prognosis in pancreatic adenocarcinoma: immunohistochemistry study showing the correlation between expression and survival

et al. 2020

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Background Various parameters have been considered for predicting survival in pancreatic ductal adenocarcinoma. Information about western population is missing. The aim of this study is to assess the association between Glucose transporter type 1 (GLUT-1) expression and prognosis for patients with PDAC submitted for surgical resection in a European cohort. Methods Retrospective analysis of PDAC specimens after pancreatoduodenectomy assessing GLUT-1 expression according to intensity (weak vs strong) and extension (low if < 80% cells were stained, high if > 80%) was performed. Statistical analysis was performed using the exact Fisher test, Student t test or the Mann-Whitney U test. Survival was analysed using the Kaplan-Meier method and compared with the Log-rank test. The differences were considered significant at a two-sided p value of < 0.05. All statistical analyses were performed using SPSS® 23.0 for Windows (SPSS Inc., Chicago, IL, USA). Results Our study consisted of 39 patients of which 58.9% presented with weak and 41.1% with strong intensity. The median extension was 90%: 28.2% cases presented with a low extension and 71.8% with a high extension. No significant differences related to intensity were found. The high-extension group showed a higher percentage of T3 PDAC (92.9% vs 63.6%, p = 0.042) and LNR20 (35.7% vs 0%, p = 0.037) as well as shorter disease-free survival (17.58 vs 54.46 months; p = 0.048). Conclusions Our findings suggest that GLUT-1 could be related to higher aggressivity in PDAC and could be used as a prognostic marker, identifying patients with a worse response to current therapies who could benefit from more aggressive treatments.

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Section: Introductionmentioning

confidence: 99%

GLUT-1 as a predictor of worse prognosis in pancreatic adenocarcinoma: immunohistochemistry study showing the correlation between expression and survival

et al. 2020

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“…It is well known that cancer cells show more rapid glucose uptake and metabolism, i.e. increased expression of glucose transporter 1 (GLUT-1) and HK-II, than normal cells; these characteristics enable rapid growth and division [50]. Hyperglycemia and hyperlipidemia are the main pathologic features of the metabolic disorders that comprise DM, and hyperglycemia implies the availability of an of the most important metabolic substrate for tumor cells [51].…”

Section: Hyperglycemiamentioning

confidence: 99%

Diabetes and its Potential Impact on Head and Neck Oncogenesis

Wang

Zhang

et al. 2020

J. Cancer

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In recent years, the incidence of diabetes mellitus and cancer has increased sharply; indeed, these have become the two most important diseases threatening health and survival. Head and neck (HN) tumors are the sixth most common malignancies in humans. Numerous studies have shown that there are many common risk factors for diabetes mellitus and HN squamous cell carcinoma, including advanced age, poor diet and lifestyle, and environmental factors. However, the mechanism linking the two diseases has not been identified. A number of studies have shown that diabetes affects the development, metastasis, and prognosis of HN cancer, potentially through the associated hyperglycemia, hyperinsulinemia and insulin resistance, or chronic inflammation. More recent studies show that metformin, the first-line drug for the treatment of type 2 diabetes, can significantly reduce the risk of HN tumor development and reduce mortality in diabetic patients. Here, we review recent progress in the study of the relationship between diabetes mellitus and HN carcinogenesis, and its potential mechanisms, in order to provide a scientific basis for the early diagnosis and effective treatment of these diseases.

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“…Mice in the Ab+ Bi+ RT group showed the highest expression of TNF-α, suggesting that Ab+ Bi+ RT plays a significant role in tumor cell apoptosis. Glut-1 is the major glucose transporter in tumor cells that provides glucose for energy production [43] . Accordingly, Glut-1 expression closely correlates with tumor invasiveness and poor prognosis.…”

Section: Dsbsmentioning

confidence: 99%

A novel radio-sensitization method for lung cancer therapy: enhanced radiosensitization induced by antigens/antibodies reaction after targeting tumor hypoxia using Bifidobacterium

Yang¹,

Wu²,

Chen³

et al. 2020

Preprint

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Background：The hypoxic microenvironment of solid tumors reduces the susceptibility of cancer cells to radiotherapy. Current treatments are focused on the development of anti-cancer agents that selectively target tumor cells with no toxicity to healthy tissue. Bacteria colonize and destroy tumors and have emerged as biological vectors that can survive in the tumor microenvironment. Methods：In this study, a Lewis lung carcinoma transplant mouse model was established and treated with a combination of bifidobacterium infantis (Bi), its specific monoclonal antibodies (Ab) and radiotherapy (RT). 18F-FDG PET/CT and 18F-FMISO PET/CT imaging were performed to monitor tumor growth and hypoxia in the tumor tissue. Phosphorylated histone (γ-H2AX), the proliferation index (Ki-67), platelet endothelial cell adhesion molecules (CD31), tumor necrosis factor-α (TNF-α), hypoxia inducible factor-1α (HIF-1α) and glucose transporter 1 (Glut-1) levels were assessed through immunohistochemistry. Results：The results showed that the combined treatment group (Ab+ Bi+ RT) displayed delayed tumor growth and prolonged the survival of mice. The combined treatment group also had lower levels of HIF-1α, Glut-1, and CD31 expression, and a lower uptake of FDG and FMISO. The tumors treated with the combination therapy also had lower levels of hypoxia, and increased γ-H2AX and TNF-α expression. Conclusion：Taken together, these data suggest that the combination of bifidobacterium infantis and its specific monoclonal antibodies can markedly improve the efﬁcacy of radiotherapy for the treatment of lung cancer.

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Roles of GLUT-1 and HK-II expression in the biological behavior of head and neck cancer

Cited by 42 publications

References 137 publications

GLUT-1 as a predictor of worse prognosis in pancreatic adenocarcinoma: immunohistochemistry study showing the correlation between expression and survival

GLUT-1 as a predictor of worse prognosis in pancreatic adenocarcinoma: immunohistochemistry study showing the correlation between expression and survival

Diabetes and its Potential Impact on Head and Neck Oncogenesis

A novel radio-sensitization method for lung cancer therapy: enhanced radiosensitization induced by antigens/antibodies reaction after targeting tumor hypoxia using Bifidobacterium

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