Roles of Heat Shock Proteins and γδT Cells in Inflammation

Hirsh, Mark; Junger, Wolfgang G.

doi:10.1165/rcmb.2008-0090tr

Cited by 38 publications

(31 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…During exposure to bacterial pathogens, prokaryotic HSPs released are the dominant antigens in the immune response; it has been speculated that bacterial HSPs may trigger an autoimmune response to mammalian HSPs. Interestingly, HSP70 presented by macrophages and neutrophils can act as an antigen for γδT cells (Hirsh and Junger 2008). Moreover, in addition to intracellular and extracellular localization, HSP70 has also been associated with the plasma membrane (De Maio 2011;Multhoff and Hightower 2011).…”

Section: Hsp70mentioning

confidence: 99%

Prevention and treatment of alopecia areata with quercetin in the C3H/HeJ mouse model

Wikramanayake

Villasante

Mauro

et al. 2012

Cell Stress and Chaperones

View full text Add to dashboard Cite

Alopecia areata (AA) is an autoimmune nonscarring hair loss disorder. AA can be acute, recurrent, or chronic. Current therapeutic options for AA are limited, and there is no effective prevention for recurrent AA. We have previously shown a correlation between the expression of HSP70 (HSPA1A/B), a heat shock protein involved in the inflammatory response, and the onset of AA in the C3H/ HeJ mouse model. In this study, we tested the effects of quercetin, a bioflavonoid with anti-inflammatory properties, on AA development and HSP70 expression in the C3H/HeJ model. Mice with spontaneous AA were treated with subcutaneous quercetin or sham injections. Hair regrowth was observed in lesional areas in all the quercetin-treated mice, but in none of the sham-treated mice. In addition, non-alopecic C3H/HeJ mice were heat-treated to induce alopecia, along with quercetin or sham injections. Whereas 24% of the heat-treated mice with sham injections developed alopecia, none of the mice receiving quercetin injections did. As expected, the level of HSP70 expression in quercetin-treated areas was comparable to control. Furthermore, we showed that systemic delivery of quercetin by intraperitoneal injections prevented/reduced spontaneous onset of AA. Our results demonstrated that quercetin provided effective treatment for AA as well as prevention of onset of AA in the C3H/HeJ model, and warrant further clinical studies to determine whether quercetin may provide both treatment for preexisting AA and prevention of recurrent AA. The ready availability of quercetin as a dietary supplement may lead to increased patient compliance and positive outcomes for AA.

show abstract

Section: Hsp70mentioning

confidence: 99%

Prevention and treatment of alopecia areata with quercetin in the C3H/HeJ mouse model

Wikramanayake

Villasante

Mauro

et al. 2012

Cell Stress and Chaperones

View full text Add to dashboard Cite

show abstract

“…Substantial evidence indicates that human ␥␦ T cells have the potential to recognize a diverse set of endogenous antigens/ ligands, such as MHC class I-related chains A and B (5), members of CD1 family (6), UL16-binding proteins (ULBPs) 2 (7,8), heat shock proteins (HSPs) (9), and F 1 -ATPase-apolipoprotein A-I complex (10). Most of these molecules are either integral membrane proteins (11) or glycosylphosphatidylinositol-anchored proteins (12), typically expressed poorly or not at all by normal cells (12)(13)(14).…”

mentioning

confidence: 99%

Ectopically Expressed Human Tumor Biomarker MutS Homologue 2 Is a Novel Endogenous Ligand That Is Recognized by Human γδ T Cells to Induce Innate Anti-tumor/Virus Immunity

Dai

Chen

et al. 2012

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: Ectopically expressed hMSH2 is a tumor biomarker; however, the mechanism of its recognition is unclear. Results: hMSH2 interacted with both TCR␥␦ and NKG2D on V␦2 T cells, resulting in V␦2 T cell activation. Its expression was up-regulated by EBV infection. Conclusion: hMSH2 is a ligand for TCR␥␦ and NKG2D. Significance: Recognition of hMSH2 by ␥␦ T cells induces innate anti-tumor/virus immunity.

show abstract

“…Nagasawa et al 36 and Hirsh and Junger 37 report that high and stable expression of HSP70 is required for normal development and function of natural regulatory T cells in humans. The low expression of HSP70 has been described in association with autoimmunity.…”

mentioning

confidence: 99%

Heat-shock protein 70 expression in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome

et al. 2010

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

The purpose of this study was to assess the diagnostic value and potentially protective capacity of heat-shock protein 70 (HSP70) in chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). In this study, seminal plasma levels of cytokines (tumor necrosis factor-a (TNF-a) and interleukin 1b (IL-1b)) and HSP70 were evaluated by enzyme-linked immunosorbent assay in 80 men: 15 healthy controls, 16 men with chronic bacterial prostatitis, 23 men with CP/CPPS IIIA and 26 with CP/CPPS IIIB. The HSP70 levels in chronic bacterial prostatitis and CP/CPPS patients were correlated with chronic prostatitis symptom index (CPSI). Significantly increased levels of cytokines (TNF-a and IL-1b) and HSP70 were observed in seminal plasmas from patients with chronic bacterial prostatitis compared with CP/CPPS patients and controls. However, only IL-1b was significantly elevated compared with CP/CPPS IIIB and controls in patients with CP/CPPS IIIA. HSP70 levels in CP/CPPS patients were significantly lower than that in controls. HSP70 concentration in seminal plasma was negatively correlated with CPSI in chronic bacterial prostatitis. The results indicated that HSP70 and IL-1b appear to be the most reliable and predictive surrogate markers to diagnose chronic bacterial prostatitis and CP/CPPS, respectively. HSP70 has an important protective role in the regulation of cell functions in chronic bacterial prostatitis. CP/CPPS would probably be detrimental to the ability of T cells and consequently suppress the expression of HSP70.

show abstract

Roles of Heat Shock Proteins and γδT Cells in Inflammation

Cited by 38 publications

References 63 publications

Prevention and treatment of alopecia areata with quercetin in the C3H/HeJ mouse model

Prevention and treatment of alopecia areata with quercetin in the C3H/HeJ mouse model

Ectopically Expressed Human Tumor Biomarker MutS Homologue 2 Is a Novel Endogenous Ligand That Is Recognized by Human γδ T Cells to Induce Innate Anti-tumor/Virus Immunity

Heat-shock protein 70 expression in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome

Contact Info

Product

Resources

About