Roles of Histamine in the Pathogenesis of Bronchial Asthma and Reevaluation of the Clinical Usefulness of Antihistamines

Yamauchi, Kohei; Shikanai, Toshiki; Nakamura, Yutaka; Kobayashi, Hitoshi; Ogasawara, Masahito; Maeyama, Kazutaka

doi:10.1248/yakushi.131.185

Cited by 10 publications

(7 citation statements)

References 7 publications

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“…As far as we know to date, there are 11 studies on functional and phenotypic alterations suspected to be related to human OCT-3 polymorphisms [28,29,30,31,32,33,34,35,36,37]. Yamauchi et al reported that four major genetic polymorphisms (S116A, R120R, I140T, and A411A) of the OCT-3 gene including synonymous alterations were investigated concerning the relationship between the allele frequency and asthma severities, and were classified into two groups (mild and moderate/severe) on the basis of the Japanese asthma severity guidelines.…”

Section: Histamine Transport In the Pathophysiology Of Asthmamentioning

confidence: 99%

“…Yamauchi et al reported that four major genetic polymorphisms (S116A, R120R, I140T, and A411A) of the OCT-3 gene including synonymous alterations were investigated concerning the relationship between the allele frequency and asthma severities, and were classified into two groups (mild and moderate/severe) on the basis of the Japanese asthma severity guidelines. Patients with moderate and/or severe symptoms exhibited significantly lower frequency of the C allele compared to those showing mild symptoms, suggesting that a genetic alteration of the OCT-3 gene may have relevance to the asthma severity [28].…”

Section: Histamine Transport In the Pathophysiology Of Asthmamentioning

confidence: 99%

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The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy

Yamauchi¹,

Ogasawara

2019

IJMS

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108

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Mast cells play a critical role in the pathogenesis of allergic asthma. Histamine is a central mediator released from mast cells through allergic reactions. Histamine plays a role in airway obstruction via smooth muscle contraction, bronchial secretion, and airway mucosal edema. However, previous clinical trials of H1 receptor antagonists (H1RAs) as a treatment for asthma were not successful. In recent years, type 2 innate immunity has been demonstrated to be involved in allergic airway inflammation. Allergic asthma is defined by IgE antibody-mediated mast cell degranulation, while group 2 innate lymphoid cells (ILC2) induce eosinophilic inflammation in nonallergic asthma without allergen-specific IgE. Anti-IgE therapy has demonstrated prominent efficacy in the treatment of severe allergic asthmatics sensitized with specific perennial allergens. Furthermore, recent trials of specific cytokine antagonists indicated that these antagonists were effective in only some subtypes of asthma. Accordingly, H1RAs may show significant clinical efficacy for some subtypes of allergic asthma in which histamine is deeply associated with the pathophysiology.

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Section: Histamine Transport In the Pathophysiology Of Asthmamentioning

confidence: 99%

Section: Histamine Transport In the Pathophysiology Of Asthmamentioning

confidence: 99%

The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy

Yamauchi¹,

Ogasawara

2019

IJMS

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108

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“…However, comorbidity of asthma and allergic rhinitis is very high (80%) and they have clinically relevant antiasthmatic properties by controlling rhinitis. [13] Confirming this statement, it was shown that antihistamines have reduced asthma symptoms in patients with seasonal allergic rhinitis when given alone or in combination with an antileukotriene. [14] The early treatment of atopic child (ETAC) study also showed that the onset of asthma was prevented by continuous antihistamine treatment.…”

Section: Antihistaminesmentioning

confidence: 82%

Role of leukotriene antagonists and antihistamines in treatment of allergic rhinitis and asthma comorbidity

Baççıoğlu¹

2013

J Med Updates

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Allergy is a reaction with inflammatory cell infiltration in the target organ which allergen has been found to cause the pathology. [1,2] Allergens cause an immunoglobulin (Ig) E dependent reaction characterized by an early and late phase reaction. Histamine is released after 15 min of exposure to allergen, whereas leukotriene is increased in the AbstractLeukotriene receptor antagonists and antihistamines are efficient in reducing symptoms of allergic rhinitis and asthma when used alone or in combination. In patients with allergic rhinitis, H1-antihistamines prevent and relieve the sneezing, itching, rhinorrhea, and nasal congestion that characterize the early and the late response to allergen. H1-antihistamines are not medications of choice in asthmatic patients, but controlling rhinitis will improve asthma concomitantly. Leukotriene antagonist such as montelukast may be an alternative treatment for mild persistent asthma as monotherapy where inhaled corticosteroid cannot be administered or alternative to long-acting beta agonist as an add-on therapy to ICS for moderate to severe persistent asthma. Although montelukast is an effective drug in allergic rhinitis indicated as monotherapy, but widely recommended as adjunct to antihistamine or intranasal corticosteroid. Antileukotriene agents are also widely used in the treatment of pediatric asthma. In children, maintenance treatment with inhaled corticosteroids in pure episodic (viral) wheeze was ineffective, but maintenance as well as intermittent montelukast was shown to have an efficient role in both episodic and multi trigger wheeze. Furthermore, their advantage to inhaled corticosteroids is that leukotriene receptor antagonists do not affect short-term lower leg growth rate in prepubertal children.Key words: Leukotriene antagonist; antihistamines; allergic rhinitis; asthma. ÖzetYaln›z bafllar›na veya kombinasyon fleklinde kullan›ld›klar›nda lökotri-yen reseptörleri ve antistaminikler alerjik rinit semptomlar›n› azaltmada etkilidir. Alerjik rinit hastalar›nda H1 antistaminikleri alerjene yan›-t›n erken ve geç dönem yan›tlar› olan aks›rma, kafl›nma, burun akmas› ve nazal konjestiyonu önlemekte ve geçirmektedir. Ast›m hastalar›nda H1-antistaminikleri seçilecek ilaçlar olmamalar›na ra¤men rinitin kontrol alt›na al›nmas› ayn› zamanda ast›m› da iyilefltirecektir. Orta-a¤›r derecede fliddetli inatç› ast›mda inhale kortikosteroidin ek tedavi olarak verilemedi¤i veya uzun etkili beta agonistin alternatif olmad›¤› durumlarda hafif derecede ve inatç› ast›m›n alternatif tedavisi olarak montelukast gibi bir lökotriyen antagonistiyle monoterapi uygulanabilir. Alerjik rinitte monoterapi olarak montelukast etkili bir ilaç olmas›na ra¤men yayg›n olarak antistamin veya intranazal kortikosteroide ek olarak öne-rilmektedir. Antilökotriyen ilaçlar yine pediyatrik ast›m›n tedavisinde yayg›n biçimde kullan›lmaktad›r. Çocuklarda kortikosteroitler inhalasyonlar›yla idame tedavisi olarak saf epizodik (viral) h›fl›lt›l› solunum (wheezing) tedavisinde etkisiz olmalar›na ra¤men hem deva...

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“…In this aspect, we scrutinized major components in our model for their involvement in clinical conditions. EMT, as the central part of this model, has been demonstrated to correlate with the severity of asthma in a recent report [40]. For β2-adrenergic receptor, the effecter of bronchodilatation, at least two polymorphisms (Arg16Gly and Gln27Glu) have been studied extensively for their association with asthma and related phenotypes [41].…”

Section: Resultsmentioning

confidence: 99%

Extraneuronal Monoamine Transporter Mediates the Permissive Action of Cortisol in the Guinea Pig Trachea: Possible Involvement of Tracheal Chondrocytes

Wang

Qiu²,

Zheng³

et al. 2013

PLoS ONE

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Cortisol, a member of glucocorticoids, could potentiate the action of catecholamine by a non-genomic mechanism. Although this permissive effect has been well appreciated in the anti-asthmatic medication, the underlying signaling pathway has remained mysterious. Here, we show that extraneuronal monoamine transporter (EMT), a membraneous reuptake transporter for circulating catecholamine clearance, is the direct target of cortisol in its permissive effect. We found that BSA-conjugated cortisol, which functions as a cortisol but cannot penetrate cell membrane, enhanced the spasmolytic effect of β-adrenoceptor agonist (isoprenaline) in histamine-sensitized tracheal spirals of guinea pigs, and pharmacological inhibition of EMT with famotidine was powerful enough to imitate the permissive action of cortisol. To our surprise, EMT protein expression was high in the chondrocytes of tracheal cartilage, but was undetectable in tracheal smooth muscle cells. The functionality of EMT was further confirmed with measurement of catecholamine uptake by tracheal chondrocytes. Moreover, cortisol-initiated membrane signaling could activate protein kinase C (PKC), which phosphorylates EMT and induces its internalization via a lipid raft-dependent pathway. Both of the mechanisms slow down the reuptake process by chondrocytes, leading to extracellular catecholamine accumulation and results in a more profound adrenergic signaling activation in tracheal smooth muscle cells. Thus, an EMT-centered pathway was proposed to explain the permissive action of cortisol. Collectively, our results highlight the role of EMT in the crosstalk between glucocorticoid and catecholamine. EMT may represent a promising target for adrenergic signaling modulation.

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Roles of Histamine in the Pathogenesis of Bronchial Asthma and Reevaluation of the Clinical Usefulness of Antihistamines

Cited by 10 publications

References 7 publications

The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy

The Role of Histamine in the Pathophysiology of Asthma and the Clinical Efficacy of Antihistamines in Asthma Therapy

Role of leukotriene antagonists and antihistamines in treatment of allergic rhinitis and asthma comorbidity

Extraneuronal Monoamine Transporter Mediates the Permissive Action of Cortisol in the Guinea Pig Trachea: Possible Involvement of Tracheal Chondrocytes

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