2023
DOI: 10.1186/s12890-023-02468-7
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Roles of hypoxic environment and M2 macrophage-derived extracellular vesicles on the progression of non-small cell lung cancer

Abstract: Background Hypoxia contributes to the development of invasive and metastatic cancer cells, and is detrimental to cancer treatment. This study aimed to explore the molecular mechanisms by which hypoxic microenvironments affect hypoxic non-small cell lung cancer (NSCLC) development and the effects of M2 macrophage-derived extracellular vesicles (EVs) on NSCLC cells. Methods A549 cells were cultured in an anoxic incubator for 48 h to construct hypoxic… Show more

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Cited by 5 publications
(1 citation statement)
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“…Competing endogenous RNAs (ceRNAs) refers to a class of non-coding RNAs, including circular RNAs and long non-coding RNAs (lncRNAs) that can bind to the target mRNAs by competing with microRNAs (miRNAs) to regulate the transcriptional level of mRNAs [ 6 ]. Considerable researches have been made in recent years and found several circular RNAs or lncRNAs that play pivotal roles in various disease progression [ 7 , 8 ]. For example, lncRNA DLEU2 acts as a miR-181a sponge to regulate SEPP1 and inhibit skeletal muscle differentiation and regeneration [ 9 ].…”
Section: Introductionmentioning
confidence: 99%
“…Competing endogenous RNAs (ceRNAs) refers to a class of non-coding RNAs, including circular RNAs and long non-coding RNAs (lncRNAs) that can bind to the target mRNAs by competing with microRNAs (miRNAs) to regulate the transcriptional level of mRNAs [ 6 ]. Considerable researches have been made in recent years and found several circular RNAs or lncRNAs that play pivotal roles in various disease progression [ 7 , 8 ]. For example, lncRNA DLEU2 acts as a miR-181a sponge to regulate SEPP1 and inhibit skeletal muscle differentiation and regeneration [ 9 ].…”
Section: Introductionmentioning
confidence: 99%