Roles of inhibition for transforming binaural properties in the brainstem auditory system

Pollak, George D.; Burger, R. Michael; Park, Thomas J.; Klug, Achim; Bauer, Eric E.

doi:10.1016/s0378-5955(02)00362-3

Cited by 66 publications

(45 citation statements)

References 86 publications

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“…The response properties established in the superior olive are then reiterated in auditory centres along the ascending neuraxis. However, numerous transformations take place which modify the basic response properties of olivary projections (Pollak et al, 2002;Pecka et al 2007). In this regard, a great deal of attentions has been focussed on the inferior colliculus which integrates a variety of both excitatory and inhibitory ascending inputs from various monaural and binaural brainstem nuclei including olivary inputs (Brunso-Bechtold et al, 1981;Oliver et al, 1995;Hutson et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

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Dynamic changes in level influence spatial coding in the lateral superior olive

Park¹,

Brand

Koch

et al. 2008

Hearing Research

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It is well established that the responses of binaural auditory neurons can adapt and change dramatically depending on the nature of a preceding sound. Examples of how the effects of ensuing stimuli play a functional role in auditory processing include motion sensitivity and precedence-like effects. To date, these types of effects have been documented at the level of the midbrain and above. Little is known about sensitivity to ensuing stimuli below in the superior olivary nuclei where binaural response properties are first established. Here we report on single cell responses in the gerbil lateral superior olive, the initial site where sensitivity to interaural level differences is established. In contrast to our expectations we found a robust sensitivity to ensuing stimuli. The majority of the cells we tested (86%), showed substantial suppression and/or enhancement to a designated target stimulus, depending on the nature of a preceding stimulus. Hence, sensitivity to ensuing stimuli is already established at the first synaptic station of binaural processing.

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Section: Introductionmentioning

confidence: 99%

“…Thus, a neuron's discharge rate to a specific binaural stimulus can change dramatically depending on the nature of a preceding stimulus. These effects have been suggested to play a role in echo suppression and in motion sensitivity (Pollak, et al, 2002;Spitzer and Semple, 1998).…”

Section: Introductionmentioning

confidence: 99%

Dynamic changes in level influence spatial coding in the lateral superior olive

Park¹,

Brand

Koch

et al. 2008

Hearing Research

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“…Three principal nuclei comprise the SOC in the rat: the lateral superior olive (LSO), the medial superior olive (MSO), and the superior paraolivary nucleus (SPN). In the rat, as in many other mammals, these three nuclei (LSO, MSO and SPN) constitute part of the main ascending afferent sources of projections to the inferior colliculus (IC) (Adams, 1979;Glendenning and Masterton, 1983;Kelly et al, 1998;Moore et al, 1995;Pollak et al, 2002). The major excitatory inputs to the IC emerge from the ipsilateral MSO and contralateral LSO.…”

Section: Introductionmentioning

confidence: 99%

Anatomical plasticity in brainstem auditory nuclei following unilateral ablation of the inferior colliculus in neonatal rats

et al. 2008

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Anatomical plasticity of projections from brainstem auditory structures to the inferior colliculus (IC) was examined in albino rats to determine the effects of unilateral destruction of the IC during early development. The IC in the right hemisphere was destroyed by aspiration on postnatal day 3. Upon reaching adulthood, the rats were examined by retrograde tract tracing methods with fluoro-gold (FG) and [

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“…This concept was later extended to the vertebrate retina and integrated into the notion of receptive field with antagonistic center-surround organization (Kuffler, 1953). Since then, lateral inhibition revealed itself as a ubiquitous mechanism that operates at all levels in sensory systems (von Bekesy, 1967;Yokoi et al, 1995;Pollak et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Dendroarchitecture and Lateral Inhibition in Thalamic Barreloids

Lavallée

Deschênes²

2004

J. Neurosci.

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Thalamic cells that relay vibrissa information to barrel cortex are clustered within whisker-related modules termed barreloids. Each barreloid receives input from one principal whisker and inhibitory inputs from reticular thalamic neurons with receptive fields that correspond to that same whisker. Although the proximal dendrites of relay cells are confined to their home barreloid, distal dendrites often extend into surrounding barreloids representing adjacent whiskers on the mystacial pad. It was proposed that this arrangement provides a substrate for a mechanism of lateral inhibition that operates remotely on extrabarreloid dendrites. In the present study, we identified adjacent whiskers that suppressed activity below background levels in barreloid cells, and we used a double-labeling protocol to relate the efficacy of inhibition to the dendroarchitecture of the cells. Significant suppression of background discharges was produced by 92% of adjacent whiskers within rows, by 48% of adjacent whiskers within arcs, but was never observed after deflection of nonadjacent whiskers. The magnitude of lateral inhibition increases linearly as the cumulated length of dendrites increases in the barreloid representing an adjacent whisker (R 2 ϭ 0.86; p Ͻ 0.0001). As distance between cell bodies and the border of an adjacent barreloid increases, dendritic length in that adjacent barreloid diminishes and so does inhibition. Considering time differences between the arrival of principal and adjacent whisker inputs in barreloids, our data suggest that inhibition operating distally on dendrites acts as a spatial filter that primarily suppresses adjacent whisker inputs and so contributes to enhance edge detection.

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Roles of inhibition for transforming binaural properties in the brainstem auditory system

Cited by 66 publications

References 86 publications

Dynamic changes in level influence spatial coding in the lateral superior olive

Dynamic changes in level influence spatial coding in the lateral superior olive

Anatomical plasticity in brainstem auditory nuclei following unilateral ablation of the inferior colliculus in neonatal rats

Dendroarchitecture and Lateral Inhibition in Thalamic Barreloids

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