Roles of Interferons in Pregnant Women with Dengue Infection: Protective or Dangerous Factors

Zhang, Hao; He, Zhiyi; Zeng, Wenting; Peng, Hong‐Juan

doi:10.1155/2017/1671607

Cited by 6 publications

(5 citation statements)

References 57 publications

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“…In this work, we provide evidence that immune and serum metal ion responses in third-trimester pregnant women infected with SARS-CoV-2 vary according to the severity of the disease. Clinical manifestations in pregnant women with COVID-19 range from asymptomatic to severe ( Sevilla-Montoya et al, 2021 ); furthermore, some studies have described that the infection triggers a peripheral maternal inflammatory response ( Zhang et al, 2017 ; Cornish et al, 2020 ; Goldstein et al, 2020 ), and changes in metal ion concentrations ( Kilbride et al, 1999 ; Sangaré et al, 2014 ). Here, we have bridged these observations by studying the systemic cytokine and metal ion profile in asymptomatic and symptomatic women, and including a more significant number of severe cases than in previous reports.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy

Vásquez-Procopio

Espejel-Núñez

Torres-Torres

et al. 2022

Front. Cell Dev. Biol.

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Pregnancy makes women more susceptible to infectious agents; however, available data on the effect of SARS-CoV-2 on pregnant women are limited. To date, inflammatory responses and changes in serum metal concentration have been reported in COVID-19 patients, but few associations between metal ions and cytokines have been described. The aim of this study was to evaluate correlations between inflammatory markers and serum metal ions in third-trimester pregnant women with varying COVID-19 disease severity. Patients with severe symptoms had increased concentrations of serum magnesium, copper, and calcium ions and decreased concentrations of iron, zinc, and sodium ions. Potassium ions were unaffected. Pro-inflammatory cytokines IL-6, TNF-α, IL-8, IL-1α, anti-inflammatory cytokine IL-4, and the IP-10 chemokine were induced in the severe presentation of COVID-19 during pregnancy. Robust negative correlations between iron/magnesium and zinc/IL-6, and a positive correlation between copper/IP-10 were observed in pregnant women with the severe form of the disease. Thus, coordinated alterations of serum metal ions and inflammatory markers – suggestive of underlying pathophysiological interactions—occur during SARS-CoV-2 infection in pregnancy.

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Section: Discussionmentioning

confidence: 99%

Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy

Vásquez-Procopio

Espejel-Núñez

Torres-Torres

et al. 2022

Front. Cell Dev. Biol.

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“…Immunologic changes that occur in mid-to-late pregnancy could lead to an increase in the risk for severe dengue if infections occur during pregnancy (9,36,37). In our study, women were screened mainly during the second and third trimesters because the woman usually come for antenatal care during that period.…”

Section: Discussionmentioning

confidence: 99%

Intensified Short Symptom Screening Program for Dengue Infection during Pregnancy, India

Naik

Robinson²,

Alexander³

et al. 2020

Emerg. Infect. Dis.

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E very year, an estimated 96 million persons worldwide are given a clinical diagnosis of severe dengue infection (1). In 2017, a total of 188,401 cases of dengue were diagnosed in India, and the mortality rate was 0.1%. The mortality rate in Maharashtra State was 0.8% in 2017, nearly 8 times higher than the national average (2,3). The prevalence of dengue infection among pregnant women is not reported, but pregnant women may be uniquely susceptible to dengue infection because of the immune changes that occur during pregnancy (4). In some countries in Southeast Asia, dengue fever is the most common cause of acute febrile illness during pregnancy (5). Dengue infection during pregnancy has been associated with poor maternal and infant outcomes, including preterm birth (6), hemorrhage, preeclampsia, and caesarean delivery (7-15). Dengue virus can also be vertically transmitted to the infant, resulting in neonatal dengue, thrombocytopenia, and cerebral hemorrhage (16-19). Vertical transmission is most likely if the infection occurs in the third trimester or is present during delivery by cesarean section (20). Despite the devastating consequences, the diagnosis of dengue infection during pregnancy remains challenging. This challenge is partially caused by overlapping signs and symptoms of dengue infection with other conditions, such as HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome, pneumonia, pulmonary embolism, and other febrile illnesses (21,22). Moreover, molecular assays to diagnose dengue are not widely available. However, there is a remarkable reduction in the case-fatality rate after early diagnosis and access to appropriate medical care (23). This study was planned after detection of Zika virus in India. The goal of this study was to determine the prevalence of dengue, chikungunya, and Zika virus among pregnant women in Pune, India. We also aimed to identify clinical predictors of these infections to improve screening and detection during the antenatal setting. Methods Ethics This study was approved by the Byramjee Jeejeebhoy Medical College Clinical Trials Unit and Johns

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“…Belonging to the same flavivirus genus, DENV and ZIKV share similarities beyond phylogeny, including host immune responses. Proteins of the type I IFN subgroup (including IFN- α, β, ε, τ, and δ) exhibited contradictory roles in DENV pathogenesis, during which certain proteins were upregulated compared to other that were reduced in infected patients [ 78 , 79 ]. For type II IFNs, elevated serum levels of dengue patients were associated with higher chances of experiencing increased severity of disease [ 79 , 80 , 81 , 82 , 83 ].…”

Section: Host Cell Restriction Factors That Limit Zikv Replicationmentioning

confidence: 99%

“…Proteins of the type I IFN subgroup (including IFN- α, β, ε, τ, and δ) exhibited contradictory roles in DENV pathogenesis, during which certain proteins were upregulated compared to other that were reduced in infected patients [ 78 , 79 ]. For type II IFNs, elevated serum levels of dengue patients were associated with higher chances of experiencing increased severity of disease [ 79 , 80 , 81 , 82 , 83 ]. In vitro studies of type III IFNs induction following DENV infection demonstrated that IFN-λ has the inhibitory potential to control DENV replication [ 84 ].…”

Section: Host Cell Restriction Factors That Limit Zikv Replicationmentioning

confidence: 99%

Advances in Zika Virus–Host Cell Interaction: Current Knowledge and Future Perspectives

Lee

Shin

2019

IJMS

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Emerging mosquito-transmitted RNA viruses, such as Zika virus (ZIKV) and Chikungunya represent human pathogens of an immense global health problem. In particular, ZIKV has emerged explosively since 2007 to cause a series of epidemics in the South Pacific and most recently in the Americas. Although typical ZIKV infections are asymptomatic, ZIKV infection during pregnancy is increasingly associated with microcephaly and other fetal developmental abnormalities. In the last few years, genomic and molecular investigations have established a remarkable progress on the pathogenic mechanisms of ZIKV infection using in vitro and in vivo models. Here, we highlight recent advances in ZIKV-host cell interaction studies, including cellular targets of ZIKV, ZIKV-mediated cell death mechanisms, host cell restriction factors that limit ZIKV replication, and immune evasion mechanisms utilized by ZIKV. Understanding of the mechanisms of ZIKV–host interaction at the cellular level will contribute crucial insights into the development of ZIKV therapeutics and vaccines.

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Roles of Interferons in Pregnant Women with Dengue Infection: Protective or Dangerous Factors

Cited by 6 publications

References 57 publications

Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy

Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy

Intensified Short Symptom Screening Program for Dengue Infection during Pregnancy, India

Advances in Zika Virus–Host Cell Interaction: Current Knowledge and Future Perspectives

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