Roles of lncRNAs and circRNAs in regulating skeletal muscle development

Chen, Rui; Liu, Si; Jiang, Ting; Zeng, Jie; Zhou, Shanyao; She, Yanling

doi:10.1111/apha.13356

Cited by 39 publications

(25 citation statements)

References 109 publications

(199 reference statements)

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“…8,9 Accumulating evidences about circRNAs have demonstrated that they can impact diverse biological processes and are also implicated in tumour generation and development. [10][11][12] The most investigated function of cir-cRNAs is as master regulators of gene expression that act to sequester or 'sponge' other gene expression regulators, such as miRNAs. 13,14 For instance, recent studies have indicated that circIFT80 functions as a competing endogenous RNA (ceRNA) of miR-1236-3p to promote the development of colorectal cancer.…”

Section: Circular Rnas (Circrnas) Are a Class Of Non-coding Rnas (Ncrmentioning

confidence: 99%

“…Circular RNAs (circRNAs) are a class of non‐coding RNAs (ncRNAs) with limited ability to encode proteins and usually form a closed circular structure covalently joined by the 3′ and 5′ ends 8,9 . Accumulating evidences about circRNAs have demonstrated that they can impact diverse biological processes and are also implicated in tumour generation and development 10‐12 . The most investigated function of circRNAs is as master regulators of gene expression that act to sequester or ‘sponge’ other gene expression regulators, such as miRNAs 13,14 .…”

Section: Introductionmentioning

confidence: 99%

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Circular RNA hsa_circ_0000658 inhibits osteosarcoma cell proliferation and migration via the miR‐1227/IRF2axis

Jiang

Chen

2020

J Cellular Molecular Medi

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Osteosarcoma (OS) is the most common type of primary bone cancer with malignancy, and it arises from malignant mesenchymal cells producing immature bone and/or osteoid. 1,2 Moreover, it ranks second in regard to the cause of death associated with cancer in children and teenagers. 3 Recently, patients with OS exhibiting no distant metastasis have been shown to project a 5-year survival rate of approximately 65%-70%, which could be attributed to surgery combined with chemotherapy, a major strategy implemented for treating OS. 4 However, this rate in patients exhibiting pulmonary metastasis at an early stage is only 20%, in spite of the advances in chemotherapeutics and surgical techniques, as OS exhibits high-grade malignancy, resistance to chemotherapies and aggressive behaviour. 5-7 Over the last two or three decades, only slight progress has been made in establishing robust treatment

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Section: Circular Rnas (Circrnas) Are a Class Of Non-coding Rnas (Ncrmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circular RNA hsa_circ_0000658 inhibits osteosarcoma cell proliferation and migration via the miR‐1227/IRF2axis

Jiang

Chen

2020

J Cellular Molecular Medi

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“…Circular RNAs are expressed in several different organs following a spatial-and temporal-specific course, which suggests their potential biofunctions (Chen and Schuman, 2016;Zhao W. et al, 2019). To date, there is a growing number of studies reporting that circRNAs could be involved in the development of mammalian tissues as in neural development (van Rossum et al, 2016;Constantin, 2018), in osteogenic differentiation (Gu et al, 2017;Huang et al, 2019), in skeletal muscle development (Chen et al, 2020) or in hematopoiesis (Bonizzato et al, 2016).…”

Section: Circrnas In Cell Differentiationmentioning

confidence: 99%

Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development

Agostino¹,

Riccioli

Cesaris

et al. 2020

Front. Cell Dev. Biol.

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In the recent years thousands of non-coding RNAs have been identified, also thanks to highthroughput sequencing technologies. Among them, circular RNAs (circRNAs) are a well-represented class characterized by the high sequence conservation and cell type specific expression in eukaryotes. They are covalently closed loops formed through back-splicing. Recently, circRNAs were shown to regulate a variety of cellular processes functioning as miRNA sponges, RBP binding molecules, transcriptional regulators, scaffold for protein translation, as well as immune regulators. A growing number of studies are showing that deregulated expression of circRNAs plays important and decisive actions during the development of several human diseases, including cancer. The research on their biogenesis and on the various molecular mechanisms in which they are involved is going very fast, however, there are still few studies that address their involvement in embryogenesis and eukaryotic development. This review has the intent to describe the most recent progress in the study of the biogenesis and molecular activities of circRNAs providing insightful information in the field of embryogenesis and cell differentiation. In addition, we describe the latest research on circRNAs as novel promising biomarkers in diverse types of tumors.

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“…Accumulating evidence have shown that lncRNAs are key regulators involved in numerous important biological processes including stem cell maintenance and differentiation, myogenesis, and adipogenesis in particular [ 11 ]. Recently, numbers of lncRNAs have been characterized in myogenesis.…”

Section: Introductionmentioning

confidence: 99%

Global transcriptomic analysis reveals Lnc-ADAMTS9 exerting an essential role in myogenesis through modulating the ERK signaling pathway

Wang

Zhang

et al. 2021

J Animal Sci Biotechnol

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Background Long non-coding RNAs (lncRNAs) are emerging key regulators involved in a variety of biological processes such as cell differentiation and development. The balance between myogenesis and adipogenesis is crucial for skeletal muscle homeostasis in humans and meat quality in farm animals. The present study aimed to reveal the global transcriptomic profiles of adipogenic (Adi-) and myogenic (Myo-) precursors derived from porcine skeletal muscle and identify lncRNAs involved in the modulation of myogenesis homeostasis in porcine skeletal muscle. Results In this study, a total of 655 novel individual lncRNAs including differentially expressed 24 lncRNAs, and 755 differentially expressed mRNAs were identified (fold change ≥2 or ≤ 0.5 and adjusted P < 0.05). Integrated results of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis accompanied by the variation of intracellular Ca2+ concentration highlighted Lnc-ADAMTS9 involved in the modulation of myogenesis homeostasis in porcine skeletal muscle. Although Lnc-ADAMTS9 knock-down did not alter the mRNA expression of ADAMTS9, we demonstrated that Lnc-ADAMTS9 can promote myogenic proliferation and myogenic differentiation of myogenic precursors through inhibiting the ERK/MAPK signaling pathway. Conclusion We deciphered a comprehensive catalog of mRNAs and lncRNAs that might be involved in the regulation of myogenesis and adipogenesis homeostasis in the skeletal muscle of pigs. The Lnc-ADAMTS9 exerts an essential role in myogenesis through the ERK signaling pathway.

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Roles of lncRNAs and circRNAs in regulating skeletal muscle development

Cited by 39 publications

References 109 publications

Circular RNA hsa_circ_0000658 inhibits osteosarcoma cell proliferation and migration via the miR‐1227/IRF2axis

Circular RNA hsa_circ_0000658 inhibits osteosarcoma cell proliferation and migration via the miR‐1227/IRF2axis

Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development

Global transcriptomic analysis reveals Lnc-ADAMTS9 exerting an essential role in myogenesis through modulating the ERK signaling pathway

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