Roles of long noncoding RNAs in gastric cancer and their clinical applications

Sun, Weiliang; Yang, Yingzhen; Xu, Cai; Xie, Youhua; Guo, Junming

doi:10.1007/s00432-016-2183-7

Cited by 114 publications

(89 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent studies of the human transcriptome have attested that an astounding number of lncRNAs might have key roles for the transcriptional regulation linked to cancer progression [7][8][9]13]. Dysregulated lncRNA expression is documented in various cancers, and their tissuespecificity makes them attractive candidates as diagnostic/prognostic biomarkers and/or therapeutic agents.…”

Section: Discussionmentioning

confidence: 99%

“…Given the properties of disease-, tissue-and developmental-specificity, lncRNA may serve as a candidate biomarker for GC diagnosis [9,13,15]. Indeed, recent evidences have confirmed that several lncRNAs may not only provide significance for GC diagnosis, stage assessment and prognosis prediction, but also serve as promising targets for GC treatment [9,13,15].…”

Section: Introductionmentioning

confidence: 99%

“…Functioned as oncogenes or tumor suppressors, lncRNAs participate in several vital steps of GC tumorigenesis and progression. Some lncRNAs including HOTAIR, HULC, LINC00152, MALAT1, MALAT2, H19, SNHG6, GHET1 and GACAT3 have been demonstrated to act as oncogenes, while other lncRNAs such as LEIGC, GAS5 and FER1L4 have been classified as tumor suppressors [9][10][11][12]. Mechanistically, lncRNAs may act as chromatin remodeler, transcriptional modulator, splicing regulator, posttranscriptional processor, enhancer, molecular decoys for miRNAs, or as a guide for protein-protein, protein-DNA and protein-RNA interaction [4,5,13,14].…”

Section: Introductionmentioning

confidence: 99%

“…Mechanistically, lncRNAs may act as chromatin remodeler, transcriptional modulator, splicing regulator, posttranscriptional processor, enhancer, molecular decoys for miRNAs, or as a guide for protein-protein, protein-DNA and protein-RNA interaction [4,5,13,14]. Given the properties of disease-, tissue-and developmental-specificity, lncRNA may serve as a candidate biomarker for GC diagnosis [9,13,15]. Indeed, recent evidences have confirmed that several lncRNAs may not only provide significance for GC diagnosis, stage assessment and prognosis prediction, but also serve as promising targets for GC treatment [9,13,15].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

LncRNA MT1JP Suppresses Gastric Cancer Cell Proliferation and Migration Through MT1JP/MiR-214-3p/RUNX3 Axis

Xü

Zhang

Zou

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Emerging evidence points towards an important role of long noncoding RNAs (lncRNAs) in the tumorigenesis and progression of gastric cancer (GC). MT1JP has recently been reported to be differentially expressed and act as a tumor suppressor in different tumors, with its mechanisms not fully understood in GC. Methods: RT-qPCR was used to detect the expression of MT1JP, miR-214-3p and RUNX3 in tumor tissues and cell lines of GC. The CCK-8 assay, colony formation, Transwell assay and wound healing assay were used to evaluate the proliferation, invasion and migration of GC cells, respectively. Bioinformatics analysis and luciferase reporter assay were performed to disclose the interaction between MT1JP, miR-214-3p and RUNX3. Western blot and immunofluorescence were applied to assess the downstream signaling of RUNX3. Results: MT1JP was found downregulated in GC tissues and cells. Low expression of MT1JP was significantly correlated with advanced TNM stage and lymphatic metastasis. The expression of plasma MT1JP was also found decreased in GC patients compared to healthy controls, with an area under the ROC curve (AUC) of 0.649 for diagnosis of GC. Gain-and loss-of-function of MT1JP revealed that MT1JP functioned as a ceRNA for miR-214-3p to facilitate RUNX3 expression and then upregulated p21 and Bim levels suppressing GC cell proliferation, invasion and migration, and promoting apoptosis. Furthermore, MT1JP overexpression suppressed tumor growth and inhibited the expression of miR-214-3p and proliferation antigen Ki-67, but increased the expression of RUNX3, p21 and Bim in vivo. Conclusions: Our results suggest a potential ceRNA regulatory network involving MT1JP regulates RUNX3 expression by competitively binding endogenous miR-214-3p in tumorigenesis and progression of GC. This mechanism may contribute to a better understanding of GC pathogenesis and provide potential therapeutic strategy for GC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

LncRNA MT1JP Suppresses Gastric Cancer Cell Proliferation and Migration Through MT1JP/MiR-214-3p/RUNX3 Axis

Xü

Zhang

Zou

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…Длин-ные некодирующие РНК играют важную роль в воз-никновении и развитии онкологических заболеваний. Длина таких транскриптов составляет более 200 нук-леотидов, они регулируют экспрессию генов на раз-ных уровнях [5]. Показана связь транскрипта, коди-руемого геном GACAT3, с размером опухоли, метаста-зированием и стадией по классификации TNM у пациентов с раком желудка.…”

Section: материал и методыunclassified

Association of the Mononucleotide Polymorphisms Rs62116755 of Gene Gacat3, Rs12170546 of Gene Parvb, Rs16994849 of Gene Plcb1, Rs78143315 of Gene Pdcd6ip With Sudden Cardiac Death

Иванова¹,

Максимов²,

Малютина³

et al. 2017

Russ J Cardiol

View full text Add to dashboard Cite

Цель. Проверка ассоциации с внезапной сердечной смертью (Всс) однонук-леотидных полиморфизмов rs62116755 гена Gacat3, rs12170546 гена PaRVB, rs16994849 гена PLcB1, rs78143315 гена Pdcd6iP, которые были выявлены в собственном полногеномном ассоциативном исследовании как молеку-лярно-генетические маркеры Всс. Материал и методы. Группа Всс (n=388, средний возраст 52,9±9,2 лет, муж-чины -77,2%, женщины -22,8%) сформирована с использованием крите-риев Всс Всемирной Организации Здравоохранения и европейского обще-ства кардиологов. Группа контроля (n=387, средний возраст 52,4±8,8 лет, мужчины -62,3%, женщины -37,7%) подобрана по полу и возрасту из банка ДНК международных исследований MONICA, HAPIee. ДНК выделена методом фенол-хлороформной экстракции. Генотипирование выполнено методом полимеразной цепной реакции с последующим анализом полиморфизма длин рестрикционных фрагментов. Результаты. Не выявлено ассоциации с Всс однонуклеотидных полиморфиз-мов rs62116755 гена Gacat3, rs78143315 гена Pdcd6iP. В группе Всс доля носителей генотипа ТТ полиморфизма rs12170546 гена PaRVB статистически значимо больше, а генотипа Тс значимо меньше, чем в контрольной группе (ОШ =1,66, 95% ДИ 1,25-2,21, p=0,001; ОШ =0,67, 95% ДИ 0,50-0,90, p=0,009, соответственно). В группе младше 50 лет частота носителей генотипа GG полиморфизма rs16994849 гена PLcB1 статистически значимо больше, а генотипа АА меньше по сравнению с контрольной группой (ОШ =4,92, 95% ДИ 1,01-23,20, p=0,032; ОШ =0,54, 95% ДИ 0,31-0,93, p=0,029, соответ-ственно). В группе мужчин старше 50 лет доля носителей генотипа GG поли-морфизма rs16994849 гена PLcB1 значимо меньше, чем в контрольной группе (ОШ =0,11, 95% ДИ 0,01-0,91, p=0,024). Заключение. Однонуклеотидные полиморфизмы rs62116755 гена Gacat3, rs78143315 гена Pdcd6iP не связаны с Всс. Генотип ТТ полиморфизма rs12170546 гена PaRVB является генотипом риска Всс, а генотип Тс обладает протективным эффектом в ее отношении. Генотип GG полиморфизма rs16994849 гена PLcB1 является генотипом риска Всс для лиц младше 50 лет и обладает протективным эффектом в группе старше 50 лет. Генотип АА поли-морфизма rs16994849 гена PLcB1 обладает протективным эффектом в отно-шении Всс для лиц младше 50 лет.

show abstract

Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies

Guo

Jiang

et al. 2019

Cancer Medicine

View full text Add to dashboard Cite

Linc00152, located on chromosome 2p11.2, is a long intergenic non‐coding RNA molecule with 828 nucleotides that is highly expressed in many types of human tumor tissues, especially in malignant tumors of the digestive system. Linc00152 promotes the occurrence and development of tumors by increasing tumor cell proliferation, invasion, metastasis, and apoptosis. Additionally, linc00152 contributes to the carcinogenesis of several cancers, including gastric cancer, liver cancer, hepatocellular carcinoma, gallbladder cancer, clear cell renal cell carcinoma, and colorectal cancer, by disturbing various signaling pathways (eg PI3K/AKT, mTOR, IL‐1, and NOTCH 1 signaling pathways). High linc00152 expression levels are associated with chemoresistance as well as poor prognosis and shorter survival. Continual advances made in the relevant research have indicated that linc00152 may be useful as a new tumor molecular biomarker, applicable for tumor diagnosis, targeted therapy, and prognosis assessment. This review summarizes the progress in the research into the relationship between linc00152 and the occurrence and development of malignancies based on molecular functions, regulatory mechanisms, and clinical applications.

show abstract

Roles of long noncoding RNAs in gastric cancer and their clinical applications

Abstract: Several lncRNAs from tissue, blood, and gastric juice have shown potential values in gastric cancer diagnosis or prognosis evaluation.

Cited by 114 publications

References 52 publications

LncRNA MT1JP Suppresses Gastric Cancer Cell Proliferation and Migration Through MT1JP/MiR-214-3p/RUNX3 Axis

LncRNA MT1JP Suppresses Gastric Cancer Cell Proliferation and Migration Through MT1JP/MiR-214-3p/RUNX3 Axis

Association of the Mononucleotide Polymorphisms Rs62116755 of Gene Gacat3, Rs12170546 of Gene Parvb, Rs16994849 of Gene Plcb1, Rs78143315 of Gene Pdcd6ip With Sudden Cardiac Death

Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies

Contact Info

Product

Resources

About