Roles of microRNA‐34a in the pathogenesis of placenta accreta

Umemura, Kota; Ishioka, Shinichi; Endo, Toshiaki; Ezaka, Yoshiaki; Takahashi, Madoka; Saito, Tsuyoshi

doi:10.1111/j.1447-0756.2012.01898.x

Cited by 44 publications

(30 citation statements)

References 33 publications

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“…Studies on human placental choriocarcinoma human placental choriocarcinoma cells (JAR) revealed that miR-34a represses Notch1, Jagged 1, Serpina-3 and possibly plasminogen activator inhibitor-1 and restricts cell invasion capacity [40][41][42].…”

Section: Invasion and Migration Of The Trophoblastsmentioning

confidence: 99%

miRNAs in pregnancy-related complications

Lycoudi

Mavreli

Mavrou

et al. 2015

Expert Review of Molecular Diagnostics

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MicroRNAs (miRNAs) constitute a highly conserved class of small non-coding RNAs, involved in post-transcriptional regulation processes by modifying the expression of specific mRNAs. During placental development, cell differentiation, adhesion, migration, apoptosis and angiogenesis are regulated by specific miRNAs and aberrant expression has been associated with the pathogenesis of pregnancy-related complications. Recent studies focusing on placental and maternal peripheral blood miRNA profiling showed different expression between normal and complicated pregnancies, providing valuable information about the pathophysiological role of miRNAs and identifying potential biomarkers for monitoring pregnancy complications. This review summarizes the current knowledge in the field and presents the possible use of miRNAs as biomarkers for early detection and monitoring of these complications.

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Section: Invasion and Migration Of The Trophoblastsmentioning

confidence: 99%

miRNAs in pregnancy-related complications

Lycoudi

Mavreli

Mavrou

et al. 2015

Expert Review of Molecular Diagnostics

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“…Several studies reported possible molecular or genetic changes in PAS compared to normal controls, such as MMP2 might be increased in placenta percreta [23], or MicroRNA-34a might be decreased in placenta accreta [29], but they only compared the genetic changes between cases and controls in groups. In this study, the CTSV staining pattern in EVT was compared between the adherent site and the non-adherent site within identical cases, and the pattern was found to differ according to the adhesion status where EVT was located.…”

Section: Discussionmentioning

confidence: 99%

Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders

Matsukawa

Sato

Kotani

et al. 2019

Gynecol Obstet Invest

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Background/Aims: The study aimed to evaluate molecular changes related to trophoblast adhesion in placenta accreta spectrum (PAS) disorders. Methods: A retrospective analysis of 10 PAS cases in which both the trophoblast adherent site and the non-adherent site were identified was performed in April 2010 and March 2013. Microarray analysis and reverse transcription polymerase chain reaction (RT-PCR) analyses were performed to extract upregulated genes in the adherent site. Gene expression changes were examined by immunohistochemistry. Results: Microarray analysis showed that 157 transcripts were > 3-fold upregulated, including the following: a disintegrin and metalloproteinase-28 (ADAM28), 3.10-fold; cathepsin V (CTSV), 3.73-fold; cathepsin S (CTSS), 3.46-fold; and matrix metalloproteinase-19 (MMP19), 3.41-fold. RT-PCR showed relatively high mRNA expressions. On immunohistochemistry, extravillous trophoblast (EVT) at the non-adherent site showed weak or no CTSV expression, whereas EVT that invaded myometrium at the adherent site showed strong expression (histological score, median [min-max], 115.6 [37.6–153.6] vs. 184.8 [56.4–222.8], p < 0.05). MMP19 showed moderate staining, with no difference between the adherent and non-adherent sites. ADAM28 and CTSS showed weak or no staining. Discussion: This limited study suggests that CTSV may be involved in the pathogenesis of PAS.

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“…Many other detection methods have been applied to miRNA studies, such as Northern blot analyses [22,57], quantitative real-time PCR [19,22,82], microarrays [21,26,57,83] and in situ hybridization (ISH) [12,84]. Northern blot assays are used, not only to detect the levels of miRNAs, but also to provide insightful information on the distribution of individual miRNA precursors in different tissues.…”

Section: Expression Of Mirnas In Human Placentamentioning

confidence: 99%

“…Several miRNAs, including miR-210 [105], miR-34a [84,131] and miR-29b [23,84] have inhibitory effects on trophoblast cell invasion. It was reported that miR-210 inhibited the migration and invasion capability of trophoblast cells by repressing Ephrin-A3 and Homeobox-A9 [105].…”

Section: Regulation Of Placental Development and Function By Mirnasmentioning

confidence: 99%

“…It was reported that miR-210 inhibited the migration and invasion capability of trophoblast cells by repressing Ephrin-A3 and Homeobox-A9 [105]. The inhibiting effect of miR-34a on trophoblast cell invasion was mediated through inhibition of Notch1 and Jagged1 signaling [131] and down-regulation of plasminogen activator inhibitor-1 (PAI-1) [84]. On the other hand, miR-29b reduced trophoblast cell invasion probably via targeting matrix metalloproteinase (MMP)-2 and integrin β1 (ITGB1) in trophoblast cell lines [23].…”

Section: Regulation Of Placental Development and Function By Mirnasmentioning

confidence: 99%

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MicroRNAs in Human Placental Development and Pregnancy Complications

Brkić

Hayder

et al. 2013

IJMS

239

174

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MicroRNAs (miRNAs) are small non-coding RNAs, which function as critical posttranscriptional regulators of gene expression by promoting mRNA degradation and translational inhibition. Placenta expresses many ubiquitous as well as specific miRNAs. These miRNAs regulate trophoblast cell differentiation, proliferation, apoptosis, invasion/migration, and angiogenesis, suggesting that miRNAs play important roles during placental development. Aberrant miRNAs expression has been linked to pregnancy complications, such as preeclampsia. Recent research of placental miRNAs focuses on identifying placental miRNA species, examining differential expression of miRNAs between placentas from normal and compromised pregnancies, and uncovering the function of miRNAs in the placenta. More studies are required to further understand the functional significance of miRNAs in placental development and to explore the possibility of using miRNAs as biomarkers and therapeutic targets for pregnancy-related disorders. In this paper, we reviewed the current knowledge about the expression and function of miRNAs in placental development, and propose future directions for miRNA studies.

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Roles of microRNA‐34a in the pathogenesis of placenta accreta

Abstract: Expression of miR-34a was downregulated in placenta accreta. In vitro experiments also showed that the invasive potential of JAR increased by suppressing miR-34a, probably through the expression of PAI-1.

Cited by 44 publications

References 33 publications

miRNAs in pregnancy-related complications

miRNAs in pregnancy-related complications

Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders

MicroRNAs in Human Placental Development and Pregnancy Complications

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