Roles of Mifepristone on the Regulation of Cytotoxic Lymphocytes and Regulatory T Cells

Abstract

Objective: To investigate the immunologic function of mifepristone, which acts as a contraceptive drug at the level of the decidua. Setting: In our hospital, 60 women (less than 63 days of amenorrhea) volunteered to terminate their pregnancies by the uterine suction evacuation method. Immunohistochemically, the transcription factor forkhead box P3 and granzyme B staining were performed to identify regulatory T cells and cytotoxic lymphocytes (CLs) in all operational subjects. CD8 (cytotoxic T cells marker) and CD56 (natural killer cells marker) staining were further performed in order to characterize the CLs subpopulations. Result: A significantly increased number of CLs was found in the decidua treated with mifepristone. Conclusion: Mifepristone increases the expression of CLs in the decidua, and it provides new insights into the immunologic function of mifepristone as a drug used for pregnancy termination.

Mifepristone inhibited the expression of B7-H2, B7-H3, B7-H4 and PD-L2 in adenomyosis

“…Studies of pregnant women showed that mifepristone can alter the endometrial immune balance and result in implantation failure. It has been shown that mifepristone exerts its effect by shifting immunological elements by enhancing the expression of cytotoxic lymphocytes [ 54 ], increasing the cytotoxicity of peripheral blood NK cells [ 55 ] and uterine NK cells [ 56 ], and enhancing antigen-specific CD4 + and CD8 + T cell inflammatory cytokines (IFN-γ) and cytotoxic molecule release (granzyme B) [ 57 ]. Mifepristone regulates Treg function mediated by dendritic cells by inhibiting the expression of TGF-β [ 58 ].…”

<p>Dedifferentiated Endometrioid Carcinomas with Neuroendocrine Differentiation: A Clinicopathological and Immunohistochemical Study of Three Cases</p>

“…Based on prior reports and our case studies, the most common clinical symptoms are postmenopausal or perimenopausal vaginal bleeding and/or abnormal vaginal discharge. [5][6][7][8][9][10][11][12][13][14][15][16] Endometrial NECs often occur in association with a more typical form of endometrioid carcinoma. 4 In our cases, the adenocarcinoma component was also low-grade endometrioid carcinoma.…”

“…Paraffin sections (4 µm) were stained with a panel of antibodies using the 2-step Envision method according to the manufacturer's instructions and visualized using 3-diaminobenzidine tetrachloride (Sigma, St Louis, MO) as described previously. 8 The sources and dilutions of the antibodies used in this study are detailed in Table 1. All primary antibodies and the detection kit were obtained from Dako Corporation (Glostrup, Denmark).…”

The Retrospective Analysis on the Influence of Taking Mifepristone and Misoprostol During First-trimester Pregnancy and Its Following Impact on Tissue Residual After Induced Abortion

“…Researches show oral mifepristone after operation can reduce the incidence of tissue residual. There have been no reports on the effects of oral mifepristone before operation on tissue residue after induced abortion [3]. In clinic, we nd some people who may take mifepristone and misoprostol, while others might take misoprostol before operation alone.…”