Roles of miR-21 in the Onset and Advancement of Colorectal Cancer (CRC)

Kordkatouli, Mohammad; Mohammadi bondarkhilli, Seyed abolghassem; Sateei, Aryan; Mahmood Janlou, Mehr Ali

doi:10.61186/mci.8.1.3

Multidiscip Cancer Investig

2024

DOI: 10.61186/mci.8.1.3

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Roles of miR-21 in the Onset and Advancement of Colorectal Cancer (CRC)

Mohammad Kordkatouli,

Seyed abolghassem Mohammadi bondarkhilli,

Aryan Sateei

et al.

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2024

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Cited by 3 publications

References 41 publications

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Recent Progress in Nanoparticle-Driven Drug Delivery Strategies for Cancer Therapy: Focus on Colorectal Cancer

Kordkatouli,

Mahmoodjanloo,

Sateei

et al. 2024

Zahedan J Res Med Sci

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Context: Nanotechnology, specifically nanoparticles, has revolutionized cancer therapy through enhanced drug delivery, precise imaging, and accurate diagnosis. Their ability to target cancer cells directly with minimal side effects makes them especially promising for treating colorectal cancer (CRC), allowing for more effective treatments. Methods: A systematic literature review was conducted across multiple databases (PubMed, Scopus, Embase, Cochrane, Web of Science, Google Scholar) using MeSH terms such as nanoparticles, cancer, drug delivery, and target cells. The objectives of this review were to examine the effectiveness of nanoparticle-based drug delivery systems, evaluate their targeting mechanisms, and assess their impact on treatment outcomes for CRC. Study eligibility, participant inclusion criteria, and specific intervention types were critically analyzed to ensure a comprehensive understanding. Results: Nanoparticle-based systems have demonstrated significant promise in shrinking tumors, improving drug accumulation at the tumor site, and facilitating easier surgical removal. These systems enhance drug efficacy, reduce toxicity, and overcome biological barriers in CRC, particularly through the use of pH-responsive and thermoresponsive nanoparticles. Conclusions: The application of nanoparticles for drug delivery represents a safe and effective treatment option, demonstrating improved targeting, reduced side effects, and enhanced therapeutic outcomes. However, further research is necessary to evaluate the long-term safety, efficacy, and scalability of these systems, alongside their optimization for clinical use in personalized treatments.

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Recent Progress in Nanoparticle-Driven Drug Delivery Strategies for Cancer Therapy: Focus on Colorectal Cancer

Kordkatouli,

Mahmoodjanloo,

Sateei

et al. 2024

Zahedan J Res Med Sci

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The Role of LncRNA ROR in Colorectal Cancer Diagnosis and Treatment

Ghasemi Najarkolaee,

Kordkatouli,

Salari

et al. 2024

Zahedan J Res Med Sci

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Context: Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths worldwide, particularly in developed countries. Despite advances in detection and treatment, CRC remains difficult to diagnose in its early stages, complicating patient outcomes. Recently, long non-coding RNAs (lncRNAs) have emerged as significant regulators in cancer biology, offering new opportunities for cancer diagnostics. Evidence Acquisition: This review highlights the molecular mechanisms through which LncRNA ROR influences CRC development, its diagnostic potential as a biomarker, and the future challenges of integrating LncRNA ROR into clinical practice. Results: Future research must focus on large-scale validation studies and explore the therapeutic implications of targeting LncRNA ROR. Conclusions: Overall, this review positions LncRNA ROR as a promising biomarker with potential applications in both CRC diagnosis and treatment.

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Therapeutic Potential of ZnO-Nanoparticles Synthesized Using Portulaca oleracea in Cancer Treatment: A Comprehensive Narrative Review

Amirazodi,

Zaman,

Khanchoupan

et al. 2024

Res. Biotechnol. Environ. Sci.

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Cancer remains a leading global health challenge, with conventional therapies often hindered by severe side effects and the emergence of resistance. Nanotechnology presents innovative approaches for targeted cancer treatment, with zinc oxide nanoparticles (ZnO-NPs) gaining attention for their ability to generate reactive oxygen species (ROS) and induce apoptosis. This review explores the green synthesis of ZnO-NPs utilizing the bioactive plant Portulaca oleracea (purslane), emphasizing its eco-friendly and biocompatible nature. This comprehensive narrative aims to investigate the synthesis, characterization, and mechanisms of action of ZnO-NPs synthesized using P. oleracea, synthesis methodologies, physicochemical properties, anticancer mechanisms, and potential applications across multiple cancer types, including breast, lung, colorectal, prostate, and ovarian cancers. Additionally, the review discusses the challenges associated with biocompatibility, scalability, and clinical applications while highlighting potential pathways for further investigation. ZnO-NPs synthesized using P. oleracea exhibit notable anticancer efficacy due to enhanced ROS generation and targeted apoptosis. Preliminary studies highlight their potential in delivering lower-toxicity alternatives, compared to conventional treatments. Despite promising results, scalability, clinical application, and long-term biocompatibility remain significant challenges. ZnO-NPs synthesized via green methods represent a transformative approach to cancer treatment. However, further research addressing biocompatibility, regulatory hurdles, and large-scale production is essential to advance their clinical application.

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Roles of miR-21 in the Onset and Advancement of Colorectal Cancer (CRC)

Cited by 3 publications

References 41 publications

Recent Progress in Nanoparticle-Driven Drug Delivery Strategies for Cancer Therapy: Focus on Colorectal Cancer

Recent Progress in Nanoparticle-Driven Drug Delivery Strategies for Cancer Therapy: Focus on Colorectal Cancer

The Role of LncRNA ROR in Colorectal Cancer Diagnosis and Treatment

Therapeutic Potential of ZnO-Nanoparticles Synthesized Using Portulaca oleracea in Cancer Treatment: A Comprehensive Narrative Review

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