Roles of MOV10 in Animal RNA Virus Infection

Liu, Xueming; Jiang, Yuming

doi:10.3389/fvets.2020.569737

Cited by 10 publications

(7 citation statements)

References 75 publications

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“…MOV10 and MOV10L1, belonging to SF1 RNA helicases, are implicated in diverse biological processes [ 1 , 8 , 20 ]. MOV10 and MOV10L1 homologs have been identified in human, mouse, frog and fly.…”

Section: Discussionmentioning

confidence: 99%

“…Mov10L1 displays a specific expression in germ cell and has a key regulatory role in piRNA biogenesis [ 21 , 23 , 24 , 31 ]. Contrarily, MOV10 shows diverse expression pattern and versatile roles [ 1 , 8 , 9 , 10 , 20 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…First, MOV10 regulates antiviral gene expressions including IFN signal and autophagy pathways. Second, MOV10 participates RNA degradation via miRNA pathways [ 8 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence

Yang

Zhang

et al. 2022

IJMS

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MOV10 and MOV10L1 both encode ATP-dependent RNA helicases. In mammals, MOV10 and MOV10L1 participate in various kinds of biological contexts, such as defense of RNA virus invasion, neuron system, germ cell and early development. However, mov10 and mov10l1 in zebrafish are obscure and the evolutionary relationships of mov10 among different species remain unclear. In this study, we found MOV10 and MOV10L1 had some variations despite they possessed the conserved feature of RNA helicase, however, they may originate from a single ancestor although they shared limited homology. A single MOV10L1 gene existed among all species, while MOV10 gene experienced lineage-specific intra-chromosomal gene duplication in several species. Interestingly, the mov10 gene expanded to three in zebrafish, which originating from a duplication by whole genome specific duplication of teleost lineage followed by a specific intra-chromosome tandem duplication. The mov10 and mov10l1 showed distinct expression profiles in early stages, however, in adult zebrafish, three mov10 genes exhibited similar diverse expression patterns in almost all tissues. We also demonstrated mov10 genes were upregulated upon virus challenge, highlighting they had redundant conserved roles in virus infection. These results provide valuable data for the evolution of MOV10 and MOV10L1 and they are important to the further functional exploration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence

Yang

Zhang

et al. 2022

IJMS

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“…Exploring the SHFL interactome further, Balinsky and colleagues lastly confirmed the co-localization of SHFL with MOV10 in DENV infected cells, both of which re-localize to the DENV replication complex to restrict DENV replication. Importantly, several studies have previously shown that MOV10, a known P-body constituent, is itself an ISG with several anti-viral functions (reviewed in [88]). This represents one of the first studies to demonstrate a direct relationship between the anti-viral function of SHFL and phase-separated RNA granules, providing a novel link between the innate immune response to viral infection and RNP granule dynamics.…”

Section: Shiftless and Rna Granules During Rna Virus Infectionmentioning

confidence: 99%

Shiftless, a Critical Piece of the Innate Immune Response to Viral Infection

Rodríguez

Muller

2022

Viruses

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Since its initial characterization in 2016, the interferon stimulated gene Shiftless (SHFL) has proven to be a critical piece of the innate immune response to viral infection. SHFL expression stringently restricts the replication of multiple DNA, RNA, and retroviruses with an extraordinary diversity of mechanisms that differ from one virus to the next. These inhibitory strategies include the negative regulation of viral RNA stability, translation, and even the manipulation of RNA granule formation during viral infection. Even more surprisingly, SHFL is the first human protein found to directly inhibit the activity of the -1 programmed ribosomal frameshift, a translation recoding strategy utilized across nearly all domains of life and several human viruses. Recent literature has shown that SHFL expression also significantly impacts viral pathogenesis in mouse models, highlighting its in vivo efficacy. To help reconcile the many mechanisms by which SHFL restricts viral replication, we provide here a comprehensive review of this complex ISG, its influence over viral RNA fate, and the implications of its functions on the virus-host arms race for control of the cell.

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“…Importantly, MOV10, one of the top MS hits, was found to be co-localized with SHFL at the viral-NS3-positive area in the perinuclear region of the DENV-infected cell, indicating that SHLF and MOV10 associate with the viral replication complex [ 22 , 32 ]. MOV10 is an ATP-dependent RNA helicase, which is reported to participate in cellular antiviral defense by regulating microRNA expression and mRNA stability [ 33 ]. Interestingly, in uninfected cells, the co-localization of SHFL and MOV10 was observed in the processing (P) body, which is a cytoplasmic granule involved in mRNA decay and translational suppression [ 34 ].…”

Section: Molecular Aspects Of Shfl In the Inhibition Of Flavivirusesmentioning

confidence: 99%

Restriction of Flaviviruses by an Interferon-Stimulated Gene SHFL/C19orf66

Suzuki

Murakawa

2022

IJMS

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Flaviviruses (the genus Flavivirus of the Flaviviridae family) include many arthropod-borne viruses, often causing life-threatening diseases in humans, such as hemorrhaging and encephalitis. Although the flaviviruses have a significant clinical impact, it has become apparent that flavivirus replication is restricted by cellular factors induced by the interferon (IFN) response, which are called IFN-stimulated genes (ISGs). SHFL (shiftless antiviral inhibitor of ribosomal frameshifting) is a novel ISG that inhibits dengue virus (DENV), West Nile virus (WNV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV) infections. Interestingly, SHFL functions as a broad-spectrum antiviral factor exhibiting suppressive activity against various types of RNA and DNA viruses. In this review, we summarize the current understanding of the molecular mechanisms by which SHFL inhibits flavivirus infection and discuss the molecular basis of the inhibitory mechanism using a predicted tertiary structure of SHFL generated by the program AlphaFold2.

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Roles of MOV10 in Animal RNA Virus Infection

Cited by 10 publications

References 75 publications

Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence

Evolutionary and Expression Analysis of MOV10 and MOV10L1 Reveals Their Origin, Duplication and Divergence

Shiftless, a Critical Piece of the Innate Immune Response to Viral Infection

Restriction of Flaviviruses by an Interferon-Stimulated Gene SHFL/C19orf66

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