Roles of Nanotechnology in Diagnosis and Treatment of Tuberculosis 

Abstract

Nanotechnology has been believed for many years ago to offer new methods for both diagnosis and treatment of tuberculosis which is globally infectious disease burden in many countries, especially in developing and under-developing countries. Nanotechnological diagnosis of tuberculosis is expected to cost cheaper than many currently available diagnostic tools. Many researches are currently ongoing in the field of synthetic carriers for antituberculosis chemotherapy both oral and inhaled routes while the potentially curative drugs are available for over 50 years.

Herbal Liposomes: Natural Network for Targeted Drug Delivery System

“…Bangham first described liposomes during the study of cell membranes in 1965 [13]. He found the liposomes to be vesicles structures composed of hydrated bilalyers that develop spontaneously as water disperses phospholipids [14,15]. More studies have been carried out on liposomes and their use in various fields, such as medicine and science [16].…”

Multidirectional Benefits of Nanotechnology in the Diagnosis, Treatment and Prevention of Tuberculosis

“…NPs can cross the intestinal permeability barrier through the transcellular or paracellular pathways into the circulation [23]. Once NPs enter inside the living system, various proteins adsorb to the surface giving rise to 'corona' and even if they are not small enough to enter inside living cell, they still could form bonding with the cell membrane due to surface defects [24]. The nanostructures engaged as drug delivery systems have multiple advantages which make them superior to conventional delivery systems.…”

Diagnosis and Treatment of Tuberculosis using Nanotechnology

“…Quantum dots (QD) are semiconductor nanocrystals with the size ranging between 2 nm to 10 nm. 5 Depending upon on the size of the particle, it illuminates di erent colors which are used to identify Mycobacterium tuberculosis.5 The traditional methods like AFB and microscopic techniques detect speci c antigen Ag85B for diagnosis TB infections. To diagnose the presence of TB, samples are visualized by conjugating antibodies with organic or inorganic dyes and observe them under uorescent or electron microscope.…”