Roles of neddylation against viral infections

Han, Kun; Zhang, Jiyan

doi:10.1038/cmi.2017.100

Cited by 16 publications

(18 citation statements)

References 16 publications

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“…In a consequence, typical targets for NF-κB such as proinflammatory cytokines (TNF-α, IL-6), chemokines (CCL2/MCP1), antirival factor (IFN-β) and adhesion molecules (ICAM) are downregulated. 25,55,57,65 However, what's puzzling is that neddylation inactivation usually promotes the accumulation of phosphorylated IκBα, rather than total IκBα, in some studies. 34,66 It may be interpreted that other protein degradation pathways are involved in the regulation.…”

Section: Neddylation-modulated Signaling Molecule In the Immune Resmentioning

confidence: 99%

“…The pharmacological blockade of the entire neddylation pathway by MLN4924 has been proven to cause accumulated IκB and stabilized NF‐κB as well. In a consequence, typical targets for NF‐κB such as proinflammatory cytokines (TNF‐α, IL‐6), chemokines (CCL2/MCP1), antirival factor (IFN‐β) and adhesion molecules (ICAM) are downregulated 25,55,57,65 . However, what's puzzling is that neddylation inactivation usually promotes the accumulation of phosphorylated IκBα, rather than total IκBα, in some studies 34,66 .…”

Section: Neddylation‐modulated Signaling Molecule In the Immune Responsementioning

confidence: 99%

“…Abnormal activation of neddylation pathway affects the proliferation, effector function, and signal transduction of diverse immune cells, leading to ectopic immune responses in vitro and in vivo. Accumulated evidence has proven that pharmacological intervention by MLN4924 and genetic deletion of key molecules in neddylation modification are inseparably related to alleviated immune‐mediated diseases, which include infection (reviewed by Han, 2018), 25 inflammation and tumor. Herein, we aim to deeply clarify the roles and underlying mechanisms of neddylation modification as a regulator in the immune system.…”

Section: Introductionmentioning

confidence: 99%

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The pivotal roles of neddylation pathway in immunoregulation

Lü

Yang

2020

Immunity Inflam & Disease

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Introduction Protein neddylation, one of the most important posttranslational modifications that tagging neuronal precursor cell‐expressed developmentally downregulated protein 8 onto substrate proteins, plays fundamental roles in the process of many cellular functions. A number of studies have demonstrated the critical roles of neddylation modification in multiple pathophysiological processes, but its regulatory role in the immune system has only been finitely unveiled. Methods In this review, the latest advances in the field of neddylation modification in regulating the immune responses are succinctly discussed. Results Neddylation modification acts as a crucial modulator of innate immune cells (neutrophils, macrophages, and dendritic cells) and lymphocytes. Dysregulation of neddylation alters characteristics and functions of those cells due to abnormal degradation of key signaling molecules involved in immunoregulation. Furthermore, the ectopic immune responses caused by the abnormal neddylation play pivotal roles in a variety of immune‐related diseases, such as infection, inflammation, and cancer. Conclusions The pivotal roles of neddylation pathway in immunoregulation are attracted more and more attention, which may provide new insights into the pathogenesis of a variety of immune‐related diseases and help to indicate new therapeutic targets and potential treatment strategies.

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Section: Neddylation-modulated Signaling Molecule In the Immune Resmentioning

confidence: 99%

Section: Neddylation‐modulated Signaling Molecule In the Immune Responsementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The pivotal roles of neddylation pathway in immunoregulation

Lü

Yang

2020

Immunity Inflam & Disease

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“…2015). NEDD8 can be hijacked by certain viruses to maintain viral genome amplification (Han & Zhang 2018). SPARCL1 is closely related to the immune process via its involvement in antigen presentation and the chemokine pathway (Zhao et al .…”

Section: Figurementioning

confidence: 99%

“…DCUN1D2 plays a critical role in neddylation, which transfers NEDD8 (a ubiquitin-like protein) to the ubiquitin ligase complex (Enchev et al 2015). NEDD8 can be hijacked by certain viruses to maintain viral genome amplification (Han & Zhang 2018). SPARCL1 is closely related to the immune process via its involvement in antigen presentation and the chemokine pathway (Zhao et al 2018).…”

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confidence: 99%

Whole‐genome sequencing reveals breed‐differential CNVs between Tongcheng and Large White pigs

Zhou

Wang

et al. 2020

Animal Genetics

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Large phenotypic differences have been observed between Tongcheng and Large White pigs. However, little is known about their genetic basis. This study performed a genome-wide comparison of CNVs between Tongcheng and Large White pigs using genome sequencing data. By combining the advantages of three different strategies (read depth, paired-end mapping and split read), we detected in total 18 687 CNVs that covered approximately 3.5% of the pig genome length for Tongcheng and Large White pigs. We identified 1864 breed-stratified CNVs (top 10%) by performing V ST statistics. Functional enrichment analyses for genes located in breed-stratified CNVs were found to be involved in pigmentation, behavior, immune system and reproductive processes, which coincide with phenotypic differences between the two breeds. Using a systematic analysis of the genome and transcriptome data, we further identified four novel breed-differential CNVs on the functional genes (disease-resistant, DCUN1D2 and SPARCL1; lipid metabolism, PLEKHA2 and SLCO1A2). Subsequent PCR validation confirmed their accurate breakpoint positions in 33 Tongcheng pigs and 33 Large White pigs. This study provides essential information on differential CNVs for further research on the genetic basis of phenotypic differences between Tongcheng and Large White pigs.

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Targeted Protein Degradation in Antiviral Drug Discovery

Wispelaere

Yang

2022

Protein Homeostasis in Drug Discovery

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Roles of neddylation against viral infections

Cited by 16 publications

References 16 publications

The pivotal roles of neddylation pathway in immunoregulation

The pivotal roles of neddylation pathway in immunoregulation

Whole‐genome sequencing reveals breed‐differential CNVs between Tongcheng and Large White pigs

Targeted Protein Degradation in Antiviral Drug Discovery

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