Roles of neutrophil/lymphocyte ratio in prognosis and in differentiation of potential beneficiaries in HER2-positive breast cancer with trastuzumab therapy
Abstract:Background
The relationship of neutrophil/lymphocyte ratio (NLR) to prognosis of HER2-positive breast cancer (BC) is not well studied. We aimed to assess the prognostic role of NLR in HER2-positive BC patients treated with or without trastuzumab.
Methods
The clinical data of 843 HER2-positive BC patients from July 2013 to July 2018 were collected. The difference among variables was calculated by chi-square test. The associations between clinicopathological factors, NLR and disease-free survival (DFS) were anal… Show more
“…Valores elevados de NLR são associados a maior recorrência e mortalidade por câncer de mama (97) e pior resposta a quimioterapia neoadjuvante (98), principalmente em tumores triplo negativos e HER2 positivos (99,100). Da mesma forma, valores elevados de PLR são associados a menor sobrevida global e maiores taxas de recorrência (101).…”
ORLANDINI, L. F. Body mass index and breast cancer, and the association with two inflammatory biomarkers, the neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio. 2021. 98 f. Tese
“…Valores elevados de NLR são associados a maior recorrência e mortalidade por câncer de mama (97) e pior resposta a quimioterapia neoadjuvante (98), principalmente em tumores triplo negativos e HER2 positivos (99,100). Da mesma forma, valores elevados de PLR são associados a menor sobrevida global e maiores taxas de recorrência (101).…”
ORLANDINI, L. F. Body mass index and breast cancer, and the association with two inflammatory biomarkers, the neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio. 2021. 98 f. Tese
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.