Roles of NG2 glial cells in diseases of the central nervous system

Xu, Jianping; Zhao, Jie; Li, Shao

doi:10.1007/s12264-011-1838-2

Cited by 24 publications

(16 citation statements)

References 96 publications

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“…In combination with previous studies, this was evidence of the fact that Aβ activates GSK-3β resulting in the increased phosphorylation of β-catenin resulting in β-catenin degradation and the inhibition of the Wnt signaling pathway [86]. This inactivation of the Wnt signaling pathway through Aβ toxicity leads to the inhibition of the differentiation of NG2-glia [87]. However, a recent studies also suggest that Aβ does not have a direct impact on the survival rate of oligodendrocytes after the induction of NG2-glia in vitro [80].…”

Section: Ng2-gliasupporting

confidence: 80%

“…Since Aβ action increases the expression levels of GSK-3β and phosphorylated β-catenin, stimulation of the Wnt/β-catenin pathway may be a potential way to mitigate AD pathology [87]. In vitro and in vivo studies, particularly on those on 3xTg-AD mice, have shown that GSK-3β inhibitor TWS119 has mitigated impaired myelination of neurons [89].…”

Section: Stimulation Of Wnt Pathway In the Treatment Of Admentioning

confidence: 99%

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A Review of the Complex Roles of Glial Cells in Alzheimer’s Disease and Potential Glial-Oriented Therapeutic Targets

Ssr¹,

Ri²,

Neelotpol³

2018

Preprint

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The pathogenesis of Alzheimer’s disease (AD) is very complicated and not well-understood. As more and more studies are performed with regards to this disease, new insights are coming to light. Much of the research in AD so far has been very neuron-oriented however, recent studies suggest that certain glial cells i.e. microglia, astrocytes, oligodendrocytes, and NG2 glia are linked to the pathogenesis of AD and may offer several potential therapeutic targets in the long-standing battle against AD. Glial cells are responsible for maintaining homeostasis (i.e. concentration of ions and neurotransmitters) within the neuronal environment of the central nervous system (CNS) and are crucial to the integrity of neurons. This review explores the (1) role of glial cells in AD pathogenesis, (2) complex functionalities of the components involved and (3) potential therapeutic targets that it could eventuate leading to a better quality of life for AD patients.

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Section: Ng2-gliasupporting

confidence: 80%

Section: Stimulation Of Wnt Pathway In the Treatment Of Admentioning

confidence: 99%

A Review of the Complex Roles of Glial Cells in Alzheimer’s Disease and Potential Glial-Oriented Therapeutic Targets

Ssr¹,

Ri²,

Neelotpol³

2018

Preprint

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show abstract

“…We next applied CellMapper to identify genes expressed in four cell types of the central nervous system—GABAergic neurons, noradrenergic neurons, serotonergic neurons, and NG2 glia—using human microarray data from the Allen Brain Atlas [ 24 ]. These cell types were selected because they are relevant to human disease [ 25 , 26 ], but have not been isolated from adult humans for expression analysis before. In addition, the relatively limited knowledge of specific markers for these cell types makes it difficult to apply algorithms that require a large training set, such as in silico nano-dissection.…”

Section: Resultsmentioning

confidence: 99%

CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types

et al. 2016

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We present a sensitive approach to predict genes expressed selectively in specific cell types, by searching publicly available expression data for genes with a similar expression profile to known cell-specific markers. Our method, CellMapper, strongly outperforms previous computational algorithms to predict cell type-specific expression, especially for rare and difficult-to-isolate cell types. Furthermore, CellMapper makes accurate predictions for human brain cell types that have never been isolated, and can be rapidly applied to diverse cell types from many tissues. We demonstrate a clinically relevant application to prioritize candidate genes in disease susceptibility loci identified by GWAS.Electronic supplementary materialThe online version of this article (doi:10.1186/s13059-016-1062-5) contains supplementary material, which is available to authorized users.

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“…Fourthly, NG2 cell/OP abundance was markedly reduced. In addition to their role as oligodendrocyte progenitors (OP) , NG2 cells have other important functions within the normal CNS, most of which involve intimate physical associations of their fine, far‐reaching processes . Therefore, such pronounced NG2 cell loss, in addition to diminishing the ability to replace oligodendroglial cells, could have adversely affected the timely differentiation of the premyOls, particularly given the suggested role of NG2 cells in the establishment of nodes .…”

Section: Discussionmentioning

confidence: 99%

Oligodendrocyte Lineage Cells in Chronic Demyelination of Multiple Sclerosis Optic Nerve

Jennings

Carroll

2014

Brain Pathology

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Reports that chronically demyelinated multiple sclerosis brain and spinal cord lesions contained immature oligodendrocyte lineage cells have generated major interest aimed at the potential for promotion of endogenous repair. Despite the prominence of the optic nerve as a lesion site and its importance in clinical disease assessment, no detailed studies of multiple sclerosis-affected optic nerve exist. This study aims to provide insight into the cellular pathology of chronic demyelination in multiple sclerosis through direct morphological and immunohistochemical analysis of optic nerve in conjunction with observations from an experimental cat optic nerve model of successful remyelination. Myelin staining was followed by immunohistochemistry to differentially label neuroglia. Digitally immortalized sections were then analyzed to generate quantification data and antigenic phenotypes including maturational stages within the oligodendrocyte lineage. It was found that some chronically demyelinated multiple sclerosis optic nerve lesions contained oligodendroglial cells and that heterogeneity existed in the presence of myelin sheaths, oligodendrocyte maturational stages and extent of axonal investment. The findings advance our understanding of oligodendrocyte activity in chronically demyelinated human optic nerve and may have implications for studies aimed at enhancement of endogenous repair in multiple sclerosis.

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Roles of NG2 glial cells in diseases of the central nervous system

Cited by 24 publications

References 96 publications

A Review of the Complex Roles of Glial Cells in Alzheimer’s Disease and Potential Glial-Oriented Therapeutic Targets

A Review of the Complex Roles of Glial Cells in Alzheimer’s Disease and Potential Glial-Oriented Therapeutic Targets

CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types

Oligodendrocyte Lineage Cells in Chronic Demyelination of Multiple Sclerosis Optic Nerve

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Roles of NG2 glial cells in diseases of the central nervous system

Cited by 24 publications

References 96 publications

A Review of the Complex Roles of Glial Cells in Alzheimer&rsquo;s Disease and Potential Glial-Oriented Therapeutic Targets

A Review of the Complex Roles of Glial Cells in Alzheimer&rsquo;s Disease and Potential Glial-Oriented Therapeutic Targets

CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types

Oligodendrocyte Lineage Cells in Chronic Demyelination of Multiple Sclerosis Optic Nerve

Contact Info

Product

Resources

About

A Review of the Complex Roles of Glial Cells in Alzheimer’s Disease and Potential Glial-Oriented Therapeutic Targets

A Review of the Complex Roles of Glial Cells in Alzheimer’s Disease and Potential Glial-Oriented Therapeutic Targets