Roles of Oxidative Stress in the Development and Progression of Breast Cancer

Nourazarian, Alireza; Kangari, Parisa; Salmaninejad, Arash

doi:10.7314/apjcp.2014.15.12.4745

Cited by 153 publications

(124 citation statements)

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“…78 Au premier rang des phénomènes dans lesquels l'inflammation est mise en cause -et avec lesquels le stress peut interférer -il y a les pathologies dégénératives du système nerveux (Collins, 2012), les cancers (Ziech, 2011 ;Powell, 2013 ;Nourazarian, 2014), le vieillissement (Delattre, 2005), mais, au-delà, toutes les pathologies chroniques sont concernées. Cela ne signifie pas que le stress et en particulier le stress professionnel soit la cause de ces pathologies, mais il est susceptible d'influencer leur apparition et leur évolution, même, par exemple, quand la maladie est clairement d'origine génétique (Torres, 2008).…”

Section: Retour à Madame Bunclassified

Souffrance au travail et enjeux de santé : le rôle charnière de l’inflammation et du stress oxydant

Davezies¹

2017

pistes

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Section: Retour à Madame Bunclassified

Souffrance au travail et enjeux de santé : le rôle charnière de l’inflammation et du stress oxydant

Davezies¹

2017

pistes

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“…Uncontrolled tissue damage is a common underlying cause of cancer (44,45). tRNA fragments were detected in the urine of cancer patients more than three decades ago and were proposed to be oncogenic molecules (46 -49).…”

Section: Tirnas In Human Biology and Disease Etiologymentioning

confidence: 99%

“…Additionally, renal ischemia/reperfusion injury and cisplatin-mediated nephrotoxicity (both of which induce tissue damage via oxidative stress) generate tiRNAs in damaged kidneys. Thus tiRNAs can be used as biomarkers to detect stress-induced tissue damage in humans.Uncontrolled tissue damage is a common underlying cause of cancer (44,45). tRNA fragments were detected in the urine of cancer patients more than three decades ago and were proposed to be oncogenic molecules (46 -49).…”

mentioning

confidence: 99%

The Many Virtues of tRNA-derived Stress-induced RNAs (tiRNAs): Discovering Novel Mechanisms of Stress Response and Effect on Human Health

Saikia

Hatzoglou

2015

Journal of Biological Chemistry

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In mammalian cells, mature tRNAs are cleaved by stress-activated ribonuclease angiogenin to generate 5-and 3-tRNA halves: a novel class of small non-coding RNAs of 30 -40 nucleotides in length. The biogenesis and biological functions of tRNA halves are emerging areas of research. This review will discuss the most recent findings on: (i) the mechanism and regulation of their biogenesis, (ii) their mechanism of action (we will specifically discuss their role in the protein synthesis inhibition and the intrinsic pathway of apoptosis), and (iii) their effects on the human physiology and disease conditions. Recent breakthroughs in high-throughput sequencing have led to a more comprehensive view of the cellular transcriptome. We are now aware of numerous additional non-protein-coding RNA (ncRNA) 3 candidates in all three domains of life, thus indicating a hidden layer of transcriptome complexity (1, 2). A more recent development in our understanding of the complexity of cellular RNomes arose with the exciting discovery that ncRNA transcripts with well described functions, such as the tRNAs, can serve as precursors for downstream cleavage events, generating yet another class of functional RNA fragments. Two major classes of tRNA fragments have been identified in human cells. The 17-26-nucleotide long tRNA-derived RNA fragments (tRFs) are products of precise processing at the 5Ј-or 3Ј-end of mature or precursor tRNAs. The tRF-5 and tRF-3 are derived from terminal ends of mature tRNAs, whereas tRF-1 are 3Ј-trailer sequences of pre-tRNAs (3). The other important class of tRNA fragments found in mammalian cells and tissues is the tRNA-derived stress-induced RNAs (tiRNAs). tiRNAs were first reported in human fetus hepatic tissue (4) and human osteosarcoma cells (U2OS), respectively (5). tRFs and tiRNAs are the newest members of the cellular ncRNA repertoire that are found in several organisms and play prominent roles in various cellular functions (6). These tRNA fragments can be generated in cells under physiological conditions and also produced as part of the cellular stress response (4 -9). In mammalian cells, tiRNAs are produced by the cleavage of mature tRNAs at positions close to the anticodon, giving rise to the 30 -40-nucleotide-long 5Ј-and 3Ј-tRNA halves, a term used interchangeably with 5Ј-and 3Ј-tiRNAs throughout this review. The enzyme responsible for this endonucleolytic cleavage is angiogenin (ANG) (4,5). ANG is a member of the pancreatic RNase superfamily distinguished by its potent in vivo angiogenic activity as well as its prominent role in cancer development and neurodegeneration (10, 11). Here we will review the ANG-induced tRNA halves (tiRNAs), their role in mammalian stress response mechanisms, and other cellular functions. Additionally, we will discuss their potential implications in the pathobiology of human diseases with a special focus on neurodegenerative disorders. ANG-induced tRNA Cleavage in Mammalian CellsEndonucleolytic cleavage of mammalian tRNAs by ANG was reported by two research groups in...

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“…The hypothesized pathways include increased concentrations of endogenous hormones and inflammation (Renehan et al, 2008). An increased concentration of oxidants, in particular reactive oxygen species (ROS) and reactive nitrogen species (RNS) exceeding the antioxidant defense system capacity (socalled oxidative stress) leads to chronic inflammation (Durackova, 2010;Liou and Storz, 2010;Reuter et al, 2010;Nourazarian, et al, 2014). There is rapidly growing evidence that chronic inflammation is a factor leading to tumor development and progression.…”

Section: Overweight Obesity Oxidative Stress and The Risk Of Breastmentioning

confidence: 99%

Overweight, Obesity, Oxidative Stress and the Risk of Breast Cancer

Kruk¹

2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (22), 9579-9586 IntroductionBreast cancer (BC) is the most frequently diagnosed cancer in women worldwide. According to global cancer statistics, 1.38 million cancer cases (692,200 in developed and 691,300 in developing countries) accounting for 23% of all new cases of cancer worldwide, occurred in 2008 (Jemal et al., 2011). Also, 458,400 total BC deaths was estimated in this year. Incidence rate depends on the world region due to differences in race/ethnicity, reproductive and hormonal factors, physical inactivity and obesity. According to Moore's and Sobue's statement "The prevailing view is that the majority of cancers are due, very largely, to the environment, with only some 5-10% being primarily related to genetic abnormalities" (Moore and Sobue, 2009, p. 149). The prevalence of obesity is high and still increases. For example, using projection models it is suggested that in 2030 a number of obese adults will be higher by 65 million in comparison with 2010 (Wang et al., 2011). In 2008, 1.46 billion of overweighted (including 502 million obese) individuals was reported in analysis of epidemiological data from 199 countries (referred to Wang et al., 2011). As reviewed by Withrow and Alter (2011), the economic costs due to obesity are estimated to be 0.7-2.8% of the total health-care costs depending on a country. According to the World Cancer Research Found and the American Institute Cancer Research statement, there is convincing and consistent evidence that body fatness is positively correlated with the incidence of BC (WCRF/ Department of Prevention and Occupational Therapy, Faculty of Physical Culture and Health Promotion, University of Szczecin, Poland *For correspondence: e-mail AbstractThere is growing scientific evidence linking excess body weight to breast cancer risk. However, there is no common consensus on this relation due partly to methodologies used, populations studied and the cancer subtype. We report here a summary of the present state of knowledge on the role of overweight and obesity in pathogenesis of breast cancer and possible mechanisms through which excess body weight might influence the risk, focusing on the role of oxidative stress in breast cancer etiology. The findings demonstrate duality of excess body weight action in dependence on menopausal status: a statistically significant increased risk in postmenopausal overweight/ obese women and non-significant preventive effect among premenopausal women. Due to several gaps in the literature on this topic, additional studies are needed. Future research should address factors influencing the excess body weight -breast cancer relationship, such as race/ethnicity, tumor subtype, receptor status, the most appropriate measure of adiposity, reproductive characteristics, and lifestyle components.

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Roles of Oxidative Stress in the Development and Progression of Breast Cancer

Cited by 153 publications

References 64 publications

Souffrance au travail et enjeux de santé : le rôle charnière de l’inflammation et du stress oxydant

Souffrance au travail et enjeux de santé : le rôle charnière de l’inflammation et du stress oxydant

The Many Virtues of tRNA-derived Stress-induced RNAs (tiRNAs): Discovering Novel Mechanisms of Stress Response and Effect on Human Health

Overweight, Obesity, Oxidative Stress and the Risk of Breast Cancer

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