Roles of pattern recognition receptors in diabetic nephropathy

Zhou, Zhifeng; Jiang, Lei; Zhao, Qing; Wang, Yu; Zhou, Jing; Chen, Qinkai; Lv, Jiannan

doi:10.1631/jzus.b1900490

Cited by 11 publications

(6 citation statements)

References 104 publications

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“…There is no doubt that pattern recognition receptors (PRRs) play a key pathogenetic role in ESRD-associated local and systemic disturbances [ 51 ]. Their ligands are conservative microbial structures—pathogen-associated molecular patterns (PAMP) and damage-associated molecular patterns (DAMP).…”

Section: General Characteristics Of the Causes And Consequences Of Esrdmentioning

confidence: 99%

The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

Гусев

Соломатина

Zhuravleva

et al. 2021

IJMS

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Chronic kidney disease can progress to end-stage chronic renal disease (ESRD), which requires the use of replacement therapy (dialysis or kidney transplant) in life-threatening conditions. In ESRD, irreversible changes in the kidneys are associated with systemic changes of proinflammatory nature and dysfunctions of internal organs, skeletal muscles, and integumentary tissues. The common components of ESRD pathogenesis, regardless of the initial nosology, are (1) local (in the kidneys) and systemic chronic low-grade inflammation (ChLGI) as a risk factor for diabetic kidney disease and its progression to ESRD, (2) inflammation of the classical type characteristic of primary and secondary autoimmune glomerulonephritis and infectious recurrent pyelonephritis, as well as immune reactions in kidney allograft rejection, and (3) chronic systemic inflammation (ChSI), pathogenetically characterized by latent microcirculatory disorders and manifestations of paracoagulation. The development of ChSI is closely associated with programmed hemodialysis in ESRD, as well as with the systemic autoimmune process. Consideration of ESRD pathogenesis from the standpoint of the theory of general pathological processes opens up the scope not only for particular but also for universal approaches to conducting pathogenetic therapies and diagnosing and predicting systemic complications in severe nephropathies.

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Section: General Characteristics Of the Causes And Consequences Of Esrdmentioning

confidence: 99%

The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

Гусев

Соломатина

Zhuravleva

et al. 2021

IJMS

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“…In this study, the dominant fungal phyla in rhizosphere soil and root endophytic microbial communities were Ascomycota, Basidiomycota and Mucoromycota. As a major fungal decomposer in soil ecosystems (Wang et al, 2013), Ascomycota plays an invaluable role in the recycling of plant residues (Zhou et al, 2016). Under anaerobic conditions, Basidiomycota can help degrade lignin (Boer et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Influence of weeding methods on rhizosphere soil and root endophytic microbial communities in tea plants

Yan,

Wang,

Wan

et al. 2024

Front. Microbiol.

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IntroductionPolyethylene mulch is a kind of inorganic mulch widely used in agriculture. The effects of plastic mulch debris on the structure of plant soil and root growth have been fully studied, but their effects on endophytic microbial communities have not been explored to a large extent.MethodsIn this study, High-throughput sequencing of bacterial 16S rRNA genes and fungal ITS region sequences were used to analyze microbial community structure and composition in rhizosphere soil and root endophytic of tea plant under three different weeding methods: polyethylene mulching, hand weeding and no weeding (CK).ResultsThe results showed that the weeding methods had no significant effect on the rhizosphere and root endophytic microbial abundance, but the rhizosphere bacterial structure covered by polyethylene mulch was significantly different than hand weeding and CK. The rhizosphere fungal diversity was also significantly higher than the other two analyzed treatments. The community abundance of rhizosphere microorganisms Acidobacteria, Candidatus Rokubacteria and Aspergillus covered by polyethylene mulch decreased significantly, whereas Bradyrhizobium, Solirubrobacterales and Alphaproteobacteria increased significantly. The abundance of bacteria Ktedonobacter, Reticulibacter, Ktedonosporobacter and Dictyobacter communities covered by polyethylene mulch was significantly changed, and the abundance of Fusarium and Nitrobacteraceae was significantly increased. Rhizosphere dominant bacteria were negatively correlated with soil available nitrogen content, while dominant fungi were significantly correlated with soil pH, total nitrogen and total potassium.DiscussionPolyethylene mulch forms an independent micro-ecological environment. At the same time, the soil nutrient environment was enriched by affecting the nitrogen cycle, and the composition of microbial community was affected. This study elucidated the effects of polyethylene mulch on soil microbial community in tea garden and provided a new theoretical understanding for weed management.

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“…Innate immune recognition receptor patterns consist of danger-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). Pattern recognition receptors (PRRs) on cell surfaces recognize DAMPs and PAMPs, which facilitate an innate immune response 42 . The abnormal physiological environment in DN patients leads to the release of DAMPs ( e .…”

Section: Major Irn Subtypesmentioning

confidence: 99%

Traditional Chinese medicine for the treatment of immune-related nephropathy: A review

Jiang,

Yao,

Guo

2024

Acta Pharmaceutica Sinica B

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Roles of pattern recognition receptors in diabetic nephropathy

Cited by 11 publications

References 104 publications

The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

The Pathogenesis of End-Stage Renal Disease from the Standpoint of the Theory of General Pathological Processes of Inflammation

Influence of weeding methods on rhizosphere soil and root endophytic microbial communities in tea plants

Traditional Chinese medicine for the treatment of immune-related nephropathy: A review

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