Radio is vital for people, especially in rural areas, to share their concerns through interactive talk shows. Understanding public perceptions of pandemics is crucial because they influence people’s attitudes and health-seeking behaviours. This study used machine learning to analyze English and Luganda radio broadcast data to understand public perceptions and perspectives on the Ebola outbreak in Uganda. Our findings revealed three main speaker categories: media personalities, community guests and listeners, and government officials. The government made the most significant effort to educate the public about the Ebola outbreak. The analysis showed that the community was hesitant to use Ebola vaccines, believing that they had not been tested on other populations where the Ebola virus had originated. The community was also concerned about the effects of the lockdown measures imposed during the COVID-19 pandemic. The analysis of the radio broadcast data revealed differences in the timing and content of the conversations between male and female speakers. These experiences can inform population-specific policies for handling ongoing and future pandemics.