Roles of testosterone and amygdaloid LTP induction in determining sex differences in fear memory magnitude

Chen, Li Shen; Tzeng, Wen Yu; Chuang, Jia Ying; Cherng, Chianfang G.; Gean, Po Wu; Yu, Lung

doi:10.1016/j.yhbeh.2014.07.008

Cited by 51 publications

(35 citation statements)

References 44 publications

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“…Developmental studies of amygdala reactivity suggest that sex differences in amygdala reactivity emerge only after puberty, with the increase in levels of steroid hormones [114, 115], and additional studies targeting late adolescence are needed in order to define a specific developmental window. However, it is notable that there are also intriguing findings pointing to prepubertal sex differences in physiological measures of arousal and HPA axis responses to stressors [48, 111, 112].…”

Section: Discussionmentioning

confidence: 99%

“…For example, in a study of fear conditioning in which female mice showed greater freezing behavior than males after conditioning to a tone, estrogen levels and even ovariectomy in females had no effect on their freezing behaviors. Instead, males showed an increase in freezing after orchidectomy, which returned again to a lower level after testosterone administration [114]. Additional experiments that manipulate hormone levels in males are needed to replicate these findings and to examine links with PAC1 genotype.…”

Section: Developmental Emergence Of Sex Differences In Risk For Ptsdmentioning

confidence: 99%

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Developmental Contributors to Trauma Response: The Importance of Sensitive Periods, Early Environment, and Sex Differences

Stevens

Rooij

Jovanović

2016

Current Topics in Behavioral Neurosciences

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This review considers early factors that interact with development to contribute to later trauma responses, including developmental sensitive periods, the effects of early environment, and the emergence of sex differences. We also describe development of neural substrates that have been associated with posttraumatic stress disorder and specifically focus on fear behavior and circuitry. Emerging evidence suggests that there may be developmental shifts around age 10 in these underlying circuits that may contribute to vulnerability. We also discuss age-related changes in the importance of caregiver availability as positive buffering factors. Hormonal changes later in development with onset during puberty appear to further shape development trajectories toward risk or resilience. We highlight these recent findings as well as the great need for further longitudinal research from middle childhood through early adulthood.

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Section: Discussionmentioning

confidence: 99%

Section: Developmental Emergence Of Sex Differences In Risk For Ptsdmentioning

confidence: 99%

Developmental Contributors to Trauma Response: The Importance of Sensitive Periods, Early Environment, and Sex Differences

Stevens

Rooij

Jovanović

2016

Current Topics in Behavioral Neurosciences

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“…Findings for the role of testosterone in fear conditioning and extinction are not yet clear. Some report no role of testosterone in contextual fear conditioning (Anagnostaras et al, 1998), while others suggest a role of testosterone in cued fear conditioning (Chen et al, 2014). Testosterone is converted to estrogen in the brain via the enzyme aromatase.…”

Section: Gonadal Hormones Stress and Fear Extinctionmentioning

confidence: 99%

Sex differences in anxiety disorders: Interactions between fear, stress, and gonadal hormones

Maeng

Milad

2015

Hormones and Behavior

308

199

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Women are more vulnerable to stress- and fear-based disorders, such as anxiety and post-traumatic stress disorder. Despite the growing literature on this topic, the neural basis of these sex differences remains unclear, and the findings appear inconsistent. The neurobiological mechanisms of fear and stress in learning and memory processes have been extensively studied, and the crosstalk between these systems is beginning to explain the disproportionate incidence and differences in symptomatology and remission within these psychopathologies. In this review, we discuss the intersect between stress and fear mechanisms and their modulation by gonadal hormones and discuss the relevance of this information to sex differences in anxiety and fear-based disorders. Understanding these converging influences is imperative to the development of more effective, individualized treatments that take sex and hormones into account.

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“…In rodents, the eCB system sexual differences appear early in development (Craft et al, 2013). Sexually dimorphic regulation of synaptic plasticity or intrinsic neuronal activity in the amygdala (Bender et al, 2017; Chen et al, 2014; Fendt et al, 2013), hippocampus (Qi et al, 2016; Harte-Hargrove et al, 2015; Inoue et al, 2014; Huang and Woolley, 2012) and PFC (Li et al, 2016; Nakajima et al, 2014) have been described, but the effects of exogenous cannabinoids on synaptic plasticity in females as well as putative sex differences in its expression remain poorly explored. Our results showed that while eCB-LTD was not affected by cannabinoid exposure in pubescent and adult males, females’ eCB-LTD was ablated.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in the behavioral and synaptic consequences of a single exposure to cannabinoid at puberty and adulthood

Borsoi

Manduca

Bara

et al. 2018

Preprint

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2Heavy cannabis consumption among adolescents is associated with significant and lasting 2 3 neurobiological, psychological and health consequences that depend on the age of first use. 4Chronic exposure to cannabinoid (CB) agonists during adolescence alters social behavior and 2 5 prefrontal cortex (PFC) activity in adult rats. However, sex differences on social behavior as 2 6well as PFC synaptic plasticity after acute CB activation remain poorly explored. Here, we 2 7 determined the consequences of a single CB activation differently affects PFC in males and 2 8 females by assessing social behavior and PFC neuronal and synaptic functions in rats during 2 9 pubertal or adulthood periods, 24h after a single in-vivo cannabinoid exposure (SCE). During 3 0 puberty, SCE reduced play behavior in females but not males. In contrast, SCE impaired 3 1 sociability in both sexes at adulthood. General exploration and memory recognition remained 3 2 normal at both ages and both sexes. At the synaptic level, SCE ablated endocannabinoid-3 3 mediated long-term depression (eCB-LTD) in the PFC of females of both ages and 3 4 heightened excitability of PFC pyramidal neurons at adulthood, while males were spared. In 3 5 contrast, SCE was associated to impaired long-term potentiation in adult males. Together, the 3 6 data indicate behavioral and synaptic sex differences in response to a single in-vivo exposure 3 7to cannabinoid at puberty and adulthood. 3 8 3 9

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Roles of testosterone and amygdaloid LTP induction in determining sex differences in fear memory magnitude

Cited by 51 publications

References 44 publications

Developmental Contributors to Trauma Response: The Importance of Sensitive Periods, Early Environment, and Sex Differences

Developmental Contributors to Trauma Response: The Importance of Sensitive Periods, Early Environment, and Sex Differences

Sex differences in anxiety disorders: Interactions between fear, stress, and gonadal hormones

Sex differences in the behavioral and synaptic consequences of a single exposure to cannabinoid at puberty and adulthood

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