2023
DOI: 10.1530/rep-22-0165
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Roles of the cumulus–oocyte transzonal network and the Fragile X protein family in oocyte competence

Abstract: The determinants of oocyte developmental competence have puzzled scientists for decades. It is known that follicular conditions can nurture the production of a high-quality oocyte, but the underlying mechanisms remain unknown. Somatic cumulus cells most proximal to the oocyte are known to have cellular extensions that reach across the zona pellucida and contact with the oocyte plasma membrane. Herein, it was found that transzonal projections (TZPs) network quality is associated with developmental competence. K… Show more

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Cited by 2 publications
(2 citation statements)
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“…PCOS symptoms include absent or irregular periods, anovulation, male-pattern hair growth, acne, acanthosis nigricans, obesity with central or distinct abdominal obesity, etc. Impaired glucose tolerance (IGT), atherogenic dyslipidaemia (AD), type 2 diabetes mellitus, hepatic steatosis, cardiovascular problems such as hypertension, and metabolic complications, as well as endometrial cancer, are all more common in these individuals [17].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…PCOS symptoms include absent or irregular periods, anovulation, male-pattern hair growth, acne, acanthosis nigricans, obesity with central or distinct abdominal obesity, etc. Impaired glucose tolerance (IGT), atherogenic dyslipidaemia (AD), type 2 diabetes mellitus, hepatic steatosis, cardiovascular problems such as hypertension, and metabolic complications, as well as endometrial cancer, are all more common in these individuals [17].…”
Section: Introductionmentioning
confidence: 99%
“…During ovulation, the oocyte is accompanied by the cumulus granulosa cells (CGCs), immediately surrounding the oocyte, supporting the oocyte by sharing nutrients and a safe, caring environment. These cells emit hyaluronic acid, stabilises the produced proteins; and collectively helping the oocyte to resume meiotic division, initiating the maturation process and facilitating the formation of adult cumulus-oocyte-complexes [17]. The mural granulosa cells (MGCs) line the antrum of developing follicles surrounding the fluid-filled section of the follicle and in close proximity to the basal lamina [18].…”
Section: Introductionmentioning
confidence: 99%