Roles of the endoplasmic reticulum stress transducer OASIS in fracture healing

Funamoto, Taro; Sekimoto, Tomohisa; Murakami, Tomohiko; Kurogi, Syuji; Imaizumi, Kazunori; Chosa, Etsuo

doi:10.1016/j.bone.2011.06.012

Cited by 20 publications

(16 citation statements)

References 26 publications

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“…We previously demonstrated that OASIS promotes the differentiation of osteoblasts and is involved in bone formation (23)(24)(25). In this study, we found that Oasis is highly expressed in goblet cells at the crypt base in the large intestine.…”

Section: Discussionsupporting

confidence: 50%

“…High expression of OASIS was observed in the osteoblasts of osseous tissues and the astrocytes of the central nervous system (20 -22). From the analysis of knockout mice, OASIS has been demonstrated to be involved in terminal differentiation and osteoblasts (23)(24)(25) and astrocytes. 3 The intestinal epithelium is composed of four distinct cell types, including the absorptive enterocytes and the goblet, Paneth, and enteroendocrine secretory cell lineages (26,27).…”

Section: The Endoplasmic Reticulum (Er)mentioning

confidence: 99%

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The Endoplasmic Reticulum Stress Transducer OASIS Is involved in the Terminal Differentiation of Goblet Cells in the Large Intestine

Asada

Saito

Kawasaki

et al. 2012

Journal of Biological Chemistry

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Section: Discussionsupporting

confidence: 50%

Section: The Endoplasmic Reticulum (Er)mentioning

confidence: 99%

The Endoplasmic Reticulum Stress Transducer OASIS Is involved in the Terminal Differentiation of Goblet Cells in the Large Intestine

Asada

Saito

Kawasaki

et al. 2012

Journal of Biological Chemistry

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“…BMP2 signaling also induces mild ER stress in osteoblasts, thereby increasing the processing and activation of Creb3L1, and increasing bone matrix deposition (Murakami et al, 2009). A recent report indicates that the same pathways are activated during the healing of bone fractures (Funamoto et al, 2011). …”

Section: Creb3l1/oasismentioning

confidence: 99%

Transcriptional regulation of secretory capacity by bZip transcription factors

Fox

Andrew

2014

Front. Biol.

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Cells of specialized secretory organs expand their secretory pathways to accommodate the increased protein load necessary for their function. The endoplasmic reticulum (ER), the Golgi apparatus and the secretory vesicles, expand not only the membrane components but also the protein machinery required for increased protein production and transport. Increased protein load causes an ER stress response akin to the Unfolded Protein Response (UPR). Recent work has implicated several bZip transcription factors in the regulation of protein components of the early secretory pathway necessary to alleviate this stress. Here, we highlight eight bZip transcription factors in regulating secretory pathway component genes. These include components of the three canonical branches of the UPR–ATF4, XBP1, and ATF6, as well as the five members of the Creb3 family of transcription factors. We review findings from both invertebrate and vertebrate model systems suggesting that all of these proteins increase secretory capacity in response to increased protein load. Finally, we propose that the Creb3 family of factors may have a dual role in secretory cell differentiation by also regulating the pathways necessary for cell cycle exit during terminal differentiation.

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“…μCT was performed using a μCT system (ScanXmate-L090H; Comscantecno, Kanagawa, Japan) as described282930.…”

Section: Methodsmentioning

confidence: 99%

“…BMA was performed by creating trabecular bone and cortical bone models for evaluation based on data obtained from μCT scans (TRI/3D-BON; RATOC System Engineering, Tokyo, Japan)282930. The trabecular bone model was cut to a 2.0-mm width proximally from the distal growth plate of the femur, and the cortical bone model was cut to a 0.5-mm width towards the narrowest part of the cortical bone in the middle of the femur.…”

Section: Methodsmentioning

confidence: 99%

Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models

Kurogi

Sekimoto

Funamoto

et al. 2017

Sci Rep

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Despite numerous genetic studies on bone metabolism, understanding of the specific mechanisms is lacking. We developed an efficient screening system to identify novel genes involved in bone metabolism using mutant mouse strains registered with the Exchangeable Gene Trap Clones (EGTC) database. From 1278 trap clones in the EGTC database, 52 candidate lines were selected in the first screening, determined based on "EST profile", "X-gal", "Related article", and "Novel gene". For the second screening, bone morphometric analysis, biomechanical strength analysis, bone X-gal staining, etc. were performed on candidate lines. Forty-two male trap lines (80.8%) showed abnormalities with either bone morphometric analysis or biomechanical strength analysis. In the screening process, X-gal staining was significantly efficient (P = 0.0057). As examples, Lbr and Nedd4 trap lines selected using the screening system showed significant bone decrease and fragility, suggesting a relationship with osteoblast differentiation. This screening system using EGTC mouse lines is extremely efficient for identifying novel genes involved in bone metabolism. The gene trap lines identified as abnormal using this screening approach are highly likely to trap important genes for bone metabolism. These selected trap mice will be valuable for use as novel bio-resources in bone research.

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Roles of the endoplasmic reticulum stress transducer OASIS in fracture healing

Cited by 20 publications

References 26 publications

The Endoplasmic Reticulum Stress Transducer OASIS Is involved in the Terminal Differentiation of Goblet Cells in the Large Intestine

The Endoplasmic Reticulum Stress Transducer OASIS Is involved in the Terminal Differentiation of Goblet Cells in the Large Intestine

Transcriptional regulation of secretory capacity by bZip transcription factors

Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models

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