Roles of the Microbiota of the Female Reproductive Tract in Gynecological and Reproductive Health

Zhu, Bin; Tao, Zhi; Edupuganti, Laahirie; Serrano, Myrna G.; Buck, Gregory A.

doi:10.1128/mmbr.00181-21

Cited by 40 publications

(40 citation statements)

References 289 publications

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“…This suggests that stronger interbacterial interactions help them escape the antibiotic, which is in line with the findings of Gustin's study (Gustin et al, 2022). Lactobacillus, which possessed higher abundance in the cured samples, had the most negative correlations due to the ability of Lactobacillus to secrete lactic acid and bactericidal substances, which inhibit the growth of BV-associated pathogenic bacteria (Zhu et al, 2022). In addition, we found Ureaplasma parvum enriched in cured samples both in the short-term cured group and in the long-term cured group and a significant negative correlation with certain BV-associated bacteria, which is consistent with the study of Xiao et al (Xiao et al, 2019).…”

Section: Differences In Vaginal Microbiome Between the Short-term Cur...supporting

confidence: 86%

Orally administratedLactobacillus gasseriTM13 andLactobacillus crispatusLG55 Can Restore the Vaginal Health of Patients Recovering from Bacterial Vaginosis

Fan

Fang

et al. 2022

Preprint

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Bacterial vaginosis (BV) is a common infection of the lower genital tract with a vaginal microbiome dysbiosis caused by decreasing of lactobacilli. Previous studies suggested that supplementation with live Lactobacillus may benefit the recovery of BV, while the outcomes vary in people from different regions. Herein, we aim to evaluate the effectiveness of oral Chinese-origin Lactobacillus with adjuvant metronidazole (MET) on treating Chinese BV patients. In total, 67 Chinese women with BV were enrolled in this parallel controlled trial and randomly assigned to two study groups: a control group treated with MET vaginal suppositories for 7 days and a probiotic group treated with oral Lactobacillus gasseri TM13 and Lactobacillus crispatus LG55 as an adjuvant to MET for 30 days. By comparing the participants with Nugent scores ≥ 7 and < 7 on days 14, 30, and 90, we found that oral administration of probiotics did not improve BV cure rates (57.14% and 67.74% at day 14, 57.14% and 58.06% at day 30, 32.14% and 48.39% at day 90 for probiotic and control group respectively). However, the probiotics were effective in restoring vaginal health after cure by showing higher proportion of participants with Nugent scores < 4 in the probiotic group compared to the control group (87.50% and 71.43% on day 14, 93.75% and 88.89% on day 30, and 77.78% and 66.67% on day 90). The relative abundance of the probiotic strains was significantly increased in the gut microbiome of the probiotic group compared to the control group at day 14, but no significance was detected after 30 and 90 days. Also, the probiotics were not detected in vaginal microbiome, suggesting that L. gasseri TM13 and L. crispatus LG55 mainly acted through the gut. A higher abundance of Prevotellatimonensis at baseline was significantly associated with long-term cure failure of BV and greatly contributed to the enrichment of the lipid IVA synthesis pathway, which could aggravate inflammation response. To sum up, L. gasseri TM13 and L. crispatus LG55 can restore the vaginal health of patients recovering from BV, and individualized intervention mode should be developed to improve BV cure rates.

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Section: Differences In Vaginal Microbiome Between the Short-term Cur...supporting

confidence: 86%

Orally administratedLactobacillus gasseriTM13 andLactobacillus crispatusLG55 Can Restore the Vaginal Health of Patients Recovering from Bacterial Vaginosis

Fan

Fang

et al. 2022

Preprint

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“…These pathogenic bacteria could cause tissue injury and increased vulnerability to urine incontinence by causing persistent in ammation de ned by neutrophil in ltration and immune molecules and cytokines activation. [11,29]. In our study, the vaginal microbiota of SUI patients showed a stronger correlation with bacterial vaginitis and a dysbiosis of microbial communities.…”

Section: Discussionsupporting

confidence: 51%

Effect of Stress Urinary Incontinence on Vaginal Microbiota Stability

Zhang,

Zhou,

Yao

et al. 2023

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Background Stress urinary incontinence and vaginal microbial dysbiosis frequently occur in postpartum women. A better understanding of the relationship between SUI and the composition of vaginal microbiota may help to prevent the emergence of vaginal diseases. However, limited research has been conducted to investigate the potential association between vaginal microbial dysbiosis and stress urinary incontinence. Results The present study revealed a strong correlation between changes in the composition of vaginal microbiota and stress urinary incontinence, with stress urinary incontinence being more likely to lead to dysbiosis of vaginal microbiota. In terms of the vaginal microbiota, both alpha diversity and evenness were significantly higher in the stress urinary incontinence group compared to the group without stress urinary incontinence. Additionally, there were notable differences in the composition of the vaginal microbiota between two groups. Specifically, among stress urinary incontinence patients, the abundance of bacteria associated with bacterial vaginosis, such as Streptococcus, Prevotella, Dialister, and Veillonella, showed an increase, while the abundance of Lactobacillus decreased. Furthermore, the vaginal microbial co-occurrence network of stress urinary incontinence patients displayed higher connectivity, complexity, and clustering. Conclusions As a result, our study emphasizes the significant role of Lactobacillus in maintaining homeostasis within the vaginal microbial community. A correlation between stress urinary incontinence and the vaginal microbiota was observed, indicating an increased risk of vaginal microbial disorders and bacterial vaginosis for individuals with stress urinary incontinence. Consequently, we anticipate that our findings will contribute novel insights into the prevention of bacterial vaginal diseases associated with stress urinary incontinence.

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“…4d and e). Maternal factors, e.g., microbial infections, have been reported to in uence the gestational age at delivery or the risk for preterm birth 35 and could subsequently impact the health state, e.g., the NICU admission, birthweight (Fig. 3c and 4c), and the development of the neonatal immune system 50 .…”

Section: Discussionmentioning

confidence: 99%

The influence of maternal factors on the neonatal microbiome and health

Buck

Zhu

Serrano

2023

Preprint

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The human microbiome plays an essential role in human health. However, the influence of maternal factors on the neonatal microbiome remains obscure. Herein, our observations suggest that the neonatal buccal microbiome is similar to the maternal buccal microbiome, but the neonatal gastrointestinal microbiome develops a unique composition at an early stage. The low complexity of the neonatal buccal microbiome is a hallmark of maternal and neonatal health, but that of the neonatal gastrointestinal microbiome is associated with maternal inflammation-related metabolites. Microbial infections in the maternal reproductive tract universally impact the complexity of the neonatal microbiomes, and the body site is most important in modulating the composition of the neonatal microbiomes. Additionally, maternal lipids attenuated the adverse influence of several maternal factors on the neonatal microbiomes. Finally, admission of neonates to the newborn intensive care unit is associated with sub-optimal states of the maternal buccal and rectal microbiomes and maternal health.

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Roles of the Microbiota of the Female Reproductive Tract in Gynecological and Reproductive Health

Cited by 40 publications

References 289 publications

Orally administratedLactobacillus gasseriTM13 andLactobacillus crispatusLG55 Can Restore the Vaginal Health of Patients Recovering from Bacterial Vaginosis

Orally administratedLactobacillus gasseriTM13 andLactobacillus crispatusLG55 Can Restore the Vaginal Health of Patients Recovering from Bacterial Vaginosis

Effect of Stress Urinary Incontinence on Vaginal Microbiota Stability

The influence of maternal factors on the neonatal microbiome and health

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