2018
DOI: 10.26717/bjstr.2018.05.001206
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Roles of the Nuclear Receptors PXR1 and PXR2 in the Regulation of Cytochrome P450 3A11 Expression in Mouse Organs and Primary-Cultured Hepatocytes

Abstract: Pregnane X receptor (PXR) is a nuclear receptor that exists in forms such as PXR1 and PXR2. Activated PXR1 heterodimerizes with retinoid X receptor to increase the transcription of cytochrome P450 3A (CYP3A), a drug-metabolizing enzyme, by binding to the PXR biding site in nuclei. PXR2 is a splice variant of PXR1, which is localized to the nuclei and down regulates the transcription of CYP3A by PXR1. The present study investigated the roles of PXR1 and PXR2 in the regulation of CYP3A11 expression in adult mous… Show more

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Cited by 1 publication
(2 citation statements)
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“…According to a paper analyzing the expression of Cyp3a in the liver of fetal and neonatal mice, Cyp3a is hardly expressed in the fetal stage, and its expression level increases and zonation formation occurs during the first week of life (Kitaoka, Hatogai, Iimura, et al., 2018; Kitaoka, Hatogai, Ochiai, et al., 2018; Ochiai et al., 2016; Ochiai et al., 2018). Thus, very few relationships between the formation of Cyp zonation and its expression levels have been clarified (Kitaoka, Hatogai, Ochiai, et al., 2018).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…According to a paper analyzing the expression of Cyp3a in the liver of fetal and neonatal mice, Cyp3a is hardly expressed in the fetal stage, and its expression level increases and zonation formation occurs during the first week of life (Kitaoka, Hatogai, Iimura, et al., 2018; Kitaoka, Hatogai, Ochiai, et al., 2018; Ochiai et al., 2016; Ochiai et al., 2018). Thus, very few relationships between the formation of Cyp zonation and its expression levels have been clarified (Kitaoka, Hatogai, Ochiai, et al., 2018).…”
Section: Discussionmentioning
confidence: 99%
“…Immunostaining was conducted as described previously (Ochiai et al, 2016(Ochiai et al, , 2018. After washing with PBS (−), the COS-7 cells cultured on coated glass cover slips were fixed with 4% paraformaldehyde (PFA)/PBS (−) at RT for 10 min.…”
Section: Immunocytochemistrymentioning
confidence: 99%