Roles of three Fusarium graminearum membrane Ca2+ channels in the formation of Ca2+ signatures, growth, development, pathogenicity and mycotoxin production

Kim, Hye Seon; Kim, Jung Eun; Son, Hokyoung; Frailey, Daniel C.; Cirino, Robert; Lee, Yin Won; Duncan, Randall L.; Czymmek, Kirk J.; Kang, Seogchan

doi:10.1016/j.fgb.2017.11.005

Cited by 19 publications

(18 citation statements)

References 51 publications

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“…As discussed earlier in this review, calcium is an essential mineral required for sexual reproduction in certain filamentous fungi. While LACS was discussed in terms of ascomatal formation, HACS is important for the forcible discharge of ascospores in F. graminearum [70,136,137]. This supports the multi-phase importance for calcium during sexual reproduction, where this element is required during the initiation of sexual development as well as in the final stages of sexual reproduction.…”

Section: Ascospore Productionmentioning

confidence: 85%

“…The LACS gene, fig1 , has been extensively studied with regards to its role during sexual reproduction in F. graminearum [69,70], A. nidulans [71], and N. crassa [69]. Interestingly, while the importance of the gene is obvious in all three species, its actual function depends on the sexual strategy being employed by the species.…”

Section: Protoascomatal Developmentmentioning

confidence: 99%

“…Interestingly, while the importance of the gene is obvious in all three species, its actual function depends on the sexual strategy being employed by the species. For example, in both F. graminearum and A. nidulans , fig1 is essential for the production of ascomata during homothallic mating [69,70,71]. However, fig1 is completely dispensable in A. nidulans when an isolate undergoes outcrossing [71].…”

Section: Protoascomatal Developmentmentioning

confidence: 99%

“…The HACS is made up of two ion channels, MID1 , a mechanosensitive protein [136], and CCH1 , an L-type protein [137]. Mutant F. graminearum strains of both these genes are defective in their ability to discharge ascospores [70,136,137], with the mutant phenotypes being partially rescued by the provision of exogenous calcium. This potentially activates the LACS, allowing for calcium transport via another pathway.…”

Section: Ascospore Productionmentioning

confidence: 99%

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It’s All in the Genes: The Regulatory Pathways of Sexual Reproduction in Filamentous Ascomycetes

Wilson

Wilken

Nest

et al. 2019

Genes

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Sexual reproduction in filamentous ascomycete fungi results in the production of highly specialized sexual tissues, which arise from relatively simple, vegetative mycelia. This conversion takes place after the recognition of and response to a variety of exogenous and endogenous cues, and relies on very strictly regulated gene, protein, and metabolite pathways. This makes studying sexual development in fungi an interesting tool in which to study gene–gene, gene–protein, and protein–metabolite interactions. This review provides an overview of some of the most important genes involved in this process; from those involved in the conversion of mycelia into sexually-competent tissue, to those involved in the development of the ascomata, the asci, and ultimately, the ascospores.

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Section: Ascospore Productionmentioning

confidence: 85%

Section: Protoascomatal Developmentmentioning

confidence: 99%

Section: Protoascomatal Developmentmentioning

confidence: 99%

Section: Ascospore Productionmentioning

confidence: 99%

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It’s All in the Genes: The Regulatory Pathways of Sexual Reproduction in Filamentous Ascomycetes

Wilson

Wilken

Nest

et al. 2019

Genes

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“…In the plant pathogen Fusarium graminearum , loss of Fig1 resulted in phenotypes with reduced hyphal growth, failed perithecia and reduced virulence ( Cavinder and Trail, 2012 ). Most recently, it was further showed that FigA in F. graminearum plays distinct roles from that of Mid1 and Cch1 in the formation of Ca 2+ signature in hyphal cells ( Kim et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

The Claudin Family Protein FigA Mediates Ca2+ Homeostasis in Response to Extracellular Stimuli in Aspergillus nidulans and Aspergillus fumigatus

et al. 2018

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The claudin family protein Fig1 is a unique fungal protein that is involved in pheromone-induced calcium influx and membrane fusion during the mating of Saccharomyces cerevisiae and Candida albicans. Whether and how Fig1 regulates Ca2+ homeostasis in response to extracellular stimuli is poorly understood. Previously, we found Aspergillus nidulans FigA, a homolog of Fig1 in S. cerevisiae, similar to the high-affinity calcium uptake system, is required for normal growth under low-Ca2+ minimal medium. In this study, using the calcium-sensitive photoprotein aequorin to monitor cytosolic free calcium concentration ([Ca2+]c) in living cells, we found that the FigA dysfunction decreases the transient [Ca2+]c induced by a high extracellular calcium stress. Furthermore, FigA acts synergistically with CchA (a high-affinity Ca2+ channel) to coordinate cytoplasmic Ca2+ influx in response to an extracellular Ca2+ stimulus. Moreover, FigA mediates ER stress-induced transient [Ca2+]c in the presence or absence of extracellular calcium. Most importantly, these [Ca2+]c responses mediated by FigA are closely related to its conserved claudin superfamily motif, which is also required for hyphal growth and asexual development in A. nidulans. Finally, the function of FigA in Aspergillus fumigatus, the most common airborne human fungal pathogen was studied. The result showed that the two FigA homologous in A. nidulans and A. fumigatus have a large degree of functional homology not only in asexual development but also in regulating transient [Ca2+]c. Our study expands the knowledge of claudin family protein FigA in Ca2+ homeostasis in response to extracellular stimuli.

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Molecular regulation of fungal secondary metabolism

Pei

Zhou³

et al. 2023

World J Microbiol Biotechnol

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Roles of three Fusarium graminearum membrane Ca2+ channels in the formation of Ca2+ signatures, growth, development, pathogenicity and mycotoxin production

Cited by 19 publications

References 51 publications

It’s All in the Genes: The Regulatory Pathways of Sexual Reproduction in Filamentous Ascomycetes

It’s All in the Genes: The Regulatory Pathways of Sexual Reproduction in Filamentous Ascomycetes

The Claudin Family Protein FigA Mediates Ca2+ Homeostasis in Response to Extracellular Stimuli in Aspergillus nidulans and Aspergillus fumigatus

Molecular regulation of fungal secondary metabolism

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