2023
DOI: 10.17305/bb.2023.8893
|View full text |Cite
|
Sign up to set email alerts
|

Roles of Trimethylamine-N-oxide in Atherosclerosis and Its Potential Therapeutic Aspect: A Literature Review

Abstract: Current research supports the evidence that the gut microbiome (GM), which consist of gut microbiota and their biologically active metabolites, is associated with atherosclerosis development. Trimethylamine-N-oxide (TMAO), a metabolite produced by the GM through trimethylamine (TMA) oxidation, significantly enhances the formation and vulnerability of atherosclerotic plaques. TMAO promotes inflammation and oxidative stress in endothelial cells, leading to vascular dysfunction and plaque formation. Dimethyl-1-bu… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2024
2024
2025
2025

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 10 publications
(1 citation statement)
references
References 64 publications
0
1
0
Order By: Relevance
“…LPS receptors CD14 and Fc g III receptor CD16 + monocytes are a subgroup with specific pro-inflammatory functions; blood TMAO concentration is positively related to the level of pro-inflammatory intermediate CD14 ++ CD16 + monocytes (Yang et al, 2023). Intermediate CD14 + + CD16 + monocytes secrete a large amount of inflammatory cytokines, such as TNF-a, to promote inflammatory responses (Oktaviono et al, 2023). The high expression of adhesion molecules, such as CD162/P-selectin glycoprotein ligand-1 (PSGL-1) and myeloperoxidase, the primary source of reactive oxidants in the innate immune response, in intermediate monocytes contributes to their thrombogenic and atherogenic properties (Wildgruber et al, 2016).…”
Section: Gut Microbiota and Post-is Cardiovascular Eventsmentioning
confidence: 99%
“…LPS receptors CD14 and Fc g III receptor CD16 + monocytes are a subgroup with specific pro-inflammatory functions; blood TMAO concentration is positively related to the level of pro-inflammatory intermediate CD14 ++ CD16 + monocytes (Yang et al, 2023). Intermediate CD14 + + CD16 + monocytes secrete a large amount of inflammatory cytokines, such as TNF-a, to promote inflammatory responses (Oktaviono et al, 2023). The high expression of adhesion molecules, such as CD162/P-selectin glycoprotein ligand-1 (PSGL-1) and myeloperoxidase, the primary source of reactive oxidants in the innate immune response, in intermediate monocytes contributes to their thrombogenic and atherogenic properties (Wildgruber et al, 2016).…”
Section: Gut Microbiota and Post-is Cardiovascular Eventsmentioning
confidence: 99%