Roles of VEGF-C and Smad4 in the Lymphangiogenesis, Lymphatic Metastasis, and Prognosis in Colon Cancer

Li, Xuemei; Liu, Baoquan; Xiao, Jianbing; Yuan, Ying; Ma, Jing; Zhang, Yafang

doi:10.1007/s11605-011-1627-2

Cited by 53 publications

(39 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, the loss of DPC4 has been demonstrated to enhance VEGF protein expression in human ovarian cancer cells (13). DPC4 expression is negatively associated with VEGF-C expression in colon cancer (33). The results of the aforementioned studies are all consistent with the results of the present study.…”

Section: Negative Expression Of Dpc4 Positive Expression Of Vegf ----supporting

confidence: 91%

The expression and underlying angiogenesis effect of DPC4 and VEGF on the progression of cervical carcinoma

2017

View full text Add to dashboard Cite

Section: Negative Expression Of Dpc4 Positive Expression Of Vegf ----supporting

confidence: 91%

The expression and underlying angiogenesis effect of DPC4 and VEGF on the progression of cervical carcinoma

2017

View full text Add to dashboard Cite

“…However, the results have not been satisfactory, at least not until now. Table 6 is a summary of recent studies, conducted to evaluate the association between TGF-β signaling molecules and clinicopathological parameters such as histologic grade of tumor, disease stage, the presence of lymph node metastasis and patient survival [8,9,18,19,20,21]. These studies have similar findings in some respects.…”

Section: Discussionmentioning

confidence: 87%

“…However, studies on the individual TGF-β signaling molecules have failed to show consistent results in association with histopathology features or survival. For instance, Bacman et al [18 ]and Li et al [21] demonstrated that there was no correlation between TGF-β1 expression and patient survival. Gulubova et al [9 ]described decreased survival with TGF-β1 expression in patients with T1-T2 stage CRCs.…”

Section: Discussionmentioning

confidence: 99%

Low Expression of Transforming Growth Factor Beta-1 in Cancer Tissue Predicts a Poor Prognosis for Patients with Stage III Rectal Cancers

Chun

Jung

Choi³

et al. 2014

Oncology

View full text Add to dashboard Cite

Objective: Transforming growth factor beta (TGF-β) plays an important role in tumorigenesis and metastasis. It works as a tumor suppressor in the normal colon, but acts as a cancer promoter during the late stages of colorectal carcinogenesis. High expression of TGF-β is known to be associated with advanced stages, tumor recurrence and decreased survival of patients. We investigated the expression of TGF-β and its signaling axis molecules and evaluated their prognostic significance in patients with stage III rectal cancers. Methods: Tissues from 201 cases of stage III rectal cancer were subjected to immunohistochemistry for TGF-β1, type II TGF-β receptor, Smad3, Smad4 and Smad7 proteins. The immunoactivities of these molecules were evaluated and the results were compared with clinicopathological variables including patient survival. Results: Low expression of TGF-β1 protein was correlated with a decreased disease-free survival in univariate Kaplan-Meier (p = 0.003) and multivariate Cox regression (HR 9.188 and 95% CI 1.256-67.198, p = 0.029) analyses. The loss of Smad4 protein expression was associated with a reduction in disease-free survival in the univariate analysis, but this finding was not significant after the multivariate analysis. Conclusion: Low expression of TGF-β1 protein is associated with a poor prognosis for patients with stage III rectal cancers.

show abstract

“…VEGF recruits monocytes/ macrophages (Barleon et al, 1996) which are reported to secrete the lymphangiogenic growth factors VEGF-C (von Marschall et al, 2003). The VEGF-C/ VEGF receptor-3 signaling system is the most efficient pathway in regulating lymphangiogenesis (Li et al, 2011). In the 67 cases, numerous thin-walled blood vessels, lymphatic vessels, or fibrous tissue are common pathologic findings, which indicated the important role of lymphangiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Gorham-Stout syndrome in mainland China: a case series of 67 patients and review of the literature

Yuan

et al. 2013

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Abstract:Objective: Gorham-Stout syndrome (GSS) is a rare disorder of uncertain etiology and unpredictable prognosis. This study aims to present a comprehensive understanding of this rare entity. Methods: A literature search in PubMed and three Chinese databases was performed to screen histologically proven GSS cases among Chinese residents in the mainland. We analyzed the patients' clinical characteristics, the value of different treatment modalities and their influence on the clinical outcome. Results: Sixty-seven cases were finally enrolled. There were 43 men (64.2%) and 24 women (35.8%). The mean age at diagnosis was 28 years (1.5-71 years). The most common clinical symptoms included pain (n=40, 59.7%), functional impairment (n=13, 19.4%), and swelling (n=12, 17.9%). The radiographic presentation of 37 cases (55.2%) was disappearance of a portion of the bone. The others presented as radiolucent foci in the intramedullary or subcortical regions. A total of 42 cases provided data on therapy, these included surgery (n=27, 40.3%), radiation therapy (n=6, 9.0%), surgery combined with radiation therapy (n=2, 3.0%), and medicine therapy (n=7, 10.4%). For 30 of these 42 cases, follow-up data were available: 21 cases had the disorder locally controlled and 9 had a symptom progression. Fortunately, the disease is not fatal in the majority of cases. Conclusions: GSS has no specific symptoms and it should be taken into consideration when an unclear massive osteolysis occurs. The efficacies of different treatment modalities are still unpredictable and further research is required to assess the values of different treatments.

show abstract

Roles of VEGF-C and Smad4 in the Lymphangiogenesis, Lymphatic Metastasis, and Prognosis in Colon Cancer

Abstract: Both Smad4 and VEGF-C are involved in lymphangiogenesis and lymphatic metastasis. Smad4 and VEGF-C expression may be clinically useful indicators for prognostic evaluation in colon cancer patients.

Cited by 53 publications

References 32 publications

The expression and underlying angiogenesis effect of DPC4 and VEGF on the progression of cervical carcinoma

The expression and underlying angiogenesis effect of DPC4 and VEGF on the progression of cervical carcinoma

Low Expression of Transforming Growth Factor Beta-1 in Cancer Tissue Predicts a Poor Prognosis for Patients with Stage III Rectal Cancers

Gorham-Stout syndrome in mainland China: a case series of 67 patients and review of the literature

Contact Info

Product

Resources

About