Roles of vitamin A in the regulation of fatty acid synthesis

Fang, Yang; Xu, Feng; Wang, Tian-Nan; Chen, Guoxun

doi:10.12998/wjcc.v9.i18.4506

Cited by 8 publications

(9 citation statements)

References 98 publications

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“…In the current study, correlation analyses provided evidence that higher inflammatory parameters, such as C-reactive protein, were significantly associated with reduced plasma VA levels. This finding supported available information showing that reduced plasma levels of VA were often associated with infection and acute inflammatory conditions [ 10 , 12 , 53 , 54 ].…”

Section: Discussionsupporting

confidence: 90%

“…VA is known to play a very important role in lipid metabolism [ 9 , 10 , 11 ]. The level of VA and its metabolite retinoic acid (RA) regulate the pivotal lipogen-ic enzymes, as well as their gene expressions involved in lipid metabolism [ 12 ]. Epidemiological and mechanism studies have indicated that VA can stimulate lipid catabolism in some tissues and contribute to reducing the incidence of obesity [ 13 ] and the risk of atherosclerotic cardiovascular disease (ASCVD) [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between Serum Vitamin A, Blood Lipid Level and Dyslipidemia among Chinese Children and Adolescents

Wang

et al. 2022

Nutrients

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Background: To study the relationship between serum vitamin A (VA) level and blood lipid profiles in children and adolescents aged 6–18 years, as well as the effect of VA on dyslipidemia. Methods: The project adopted a multistage stratified cluster sampling method. The Food Frequency Questionnaire (FFQ) was used to obtain dietary factors data. Blood samples of subjects were taken via venipuncture. Generalized linear models were used to explore the correlation be-tween VA and biochemical indicators, as well as stratified and inter-actions analysis to explore the influence of confounders on these relationships. Generalized linear models were constructed to explore the association between VA and blood lipids. Restricted cubic splines were used to characterize dose–response associations between serum VA and dyslipidemia based on logistic regression. Results: Serum VA was positively correlated with TC, TG and HDL-C (p < 0.05), but these associations were influenced by age (p < 0.05). The adjusted odds ratio (OR) values of VA for hypercho lesterolemia, hypertriglyceridemia, mixed hyperlipidemia and low high-density lipoprotein cholesterolemia were 3.283, 3.239, 5.219 and 0.346, respectively (p < 0.01). Meanwhile, significant age interactions affected the relationship between VA and TC, as well as TG and LDL-C (p < 0.01). Conclusion: Serum VA was positively correlated with blood lipids, but these associations were influenced by age. VA was a risk factor for dyslipidemias, such as hypercholesterolemia, hypertriglyceridemia and mixed hyperlipidemia, but was a protective factor for low high-density lipoprotein cholesterolemia.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Association between Serum Vitamin A, Blood Lipid Level and Dyslipidemia among Chinese Children and Adolescents

Wang

et al. 2022

Nutrients

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“…In obesity, white adipose tissue secretes large amounts of adipokines, including RBP4, which have local and systemic effects (retinol homeostasis and transport) and contribute to IR ( 15 , 32 ). The association between elevated serum levels of RBP4 (analyzed by ELISA) and obesity/T2D was reported by Yang et al ( 26 ) in the Chinese population in obese patients with and without diabetes. However, no significant association was noted between non-diabetic and diabetic groups, suggesting that hyperglycemia was not associated with elevated serum RBP4 levels ( 33 ).…”

Section: Rbp4 In Obesitymentioning

confidence: 53%

“…To accomplish this, it must be converted to retinaldehyde by the enzyme retinol dehydrogenase 10. Subsequently, retinaldehyde is oxidized to RA by retinaldehyde dehydrogenases 1–3 ( 26 – 28 ). RA activates or suppresses gene transcription via nuclear receptors, namely retinoic acid receptor (RAR)α, RARβ and RARγ ( 28 , 29 ).…”

Section: Rbp4mentioning

confidence: 99%

Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review)

et al. 2022

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Obesity is a multifactorial disease, defined as excessive fat deposition in adipose tissue. Adipose tissue is responsible for the production and secretion of numerous adipokines that induce metabolic disorders. Retinol-binding protein 4 (RBP4) is an adipokine that transports vitamin A or retinol in the blood. High levels of RBP4 are associated with development of metabolic disease, including obesity, insulin resistance (IR), metabolic syndrome, and type 2 diabetes (T2D). The present review summarizes the role of RBP4 in obesity and associated chronic alterations. Excessive synthesis of RBP4 contributes to inflammatory characteristic of obesity by activation of immune cells and release of proinflammatory cytokines, such as TNFα and ILs, via the Toll-like receptor/JNK pathway. The retinol-RBP4 complex inhibits insulin signaling directly in adipocytes by activating Janus kinase 2 (JAK2)/STAT5/suppressor of cytokine signaling 3 signaling. This mechanism is retinol-dependent and requires vitamin A receptor stimulation by retinoic acid 6 (STRA6). In muscle, RBP4 is associated with increased serine 307 phosphorylation of insulin receptor substrate-1, which decreases its affinity to PI3K and promotes IR. In the liver, RBP4 increases hepatic expression of phosphoenolpyruvate carboxykinase, which increases production of glucose. Elevated serum RBP4 levels are associated with β-cell dysfunction in T2D via the STRA6/JAK2/STAT1/insulin gene enhancer protein 1 pathway. By contrast, RBP4 induces endothelial inflammation via the NF-κB/nicotinamide adenine dinucleotide phosphate oxidase pathway independently of retinol and STRA6, which stimulates expression of proinflammatory molecules, such as vascular cell adhesion molecule 1, E-selectin, intercellular adhesion molecule 1, monocyte chemoattractant protein 1 and TNFα. RBP4 promotes oxidative stress by decreasing endothelial mitochondrial function; overall, it may serve as a useful biomarker in the diagnosis of obesity and prognosis of associated disease, as well as a potential therapeutic target for treatment of these diseases.

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“…Studies have shown that vitamin A plays a role in regulating glucose and fatty acid metabolism. RA regulates the expression level of the enzymes involved in fatty acid synthesis [ 49 ], while fatty acids and retinoids control the lipid metabolism by activating the peroxisome proliferator-activated receptor (PPAR)-RXR dimer [ 50 ]. Shijin Yin et al [ 51 ] found that high retinoid concentrations trigger sensory hypersensitivity through the activation of TRPV1 receptors, while oral or intrathecal administration of all-trans retinoic acid (ATRA) can induce nociceptive behaviors in rodents [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

A Metabolomic Study of the Analgesic Effect of Lappaconitine Hydrobromide (LAH) on Inflammatory Pain

Wang

et al. 2022

Metabolites

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Lappaconitine (LA) is a C-18 diterpene alkaloid isolated from Aconitum sinomontanum Nakai that has been shown to relieve mild to moderate discomfort. Various researchers have tried to explain the underlying mechanism of LA’s effects on chronic pain. This article uses metabolomics technology to investigate the metabolite alterations in the dorsal root ganglion (DRG) when lappaconitine hydrobromide (LAH) was injected in an inflammatory pain model, to explain the molecular mechanism of its analgesia from a metabolomics perspective. The pain model used in this study was a complete Freund’s adjuvant (CFA)-induced inflammatory pain model in rats. There were two treatment groups receiving different dosages of LAH (4 mg/kg LAH and 8 mg/kg LAH). The analgesic mechanism of LAH was investigated with an analgesic behavioral test, tissue sections, and metabolomics. The results of the analgesic behavioral experiment showed that both 4 mg/kg LAH and 8 mg/kg LAH could significantly improve the paw withdrawal latency (PWL) of rats. The tissue section results showed that LAH could reduce the inflammatory response and enlargement of the paw and ankle of rats and that there was no significant difference in the tissue sections of the DRG. The metabolomics results showed that retinol metabolism and glycerophospholipid metabolism in the CFA-induced inflammatory pain model were significantly affected and may exacerbate the inflammatory reactions and initiate persistent pain; in addition, the linoleic acid metabolism, arachidonic acid metabolism, and alanine, aspartate, and glutamate metabolism were also slightly affected. Among them, the alpha-linolenic acid metabolism was up-regulated after LAH treatment, while the retinol metabolism was down-regulated. These results suggest that LAH could effectively reduce inflammatory pain and might achieve this by regulating the lipid metabolism in the rat DRG.

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Roles of vitamin A in the regulation of fatty acid synthesis

Cited by 8 publications

References 98 publications

Association between Serum Vitamin A, Blood Lipid Level and Dyslipidemia among Chinese Children and Adolescents

Association between Serum Vitamin A, Blood Lipid Level and Dyslipidemia among Chinese Children and Adolescents

Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review)

A Metabolomic Study of the Analgesic Effect of Lappaconitine Hydrobromide (LAH) on Inflammatory Pain

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