2023
DOI: 10.3892/ijmm.2023.5330
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Roles of vitamin K‑dependent protein in biomineralization (Review)

Meng Zhang,
Qingqi Zhang,
Pengfei Du
et al.

Abstract: Vitamin K (VK), a fat-soluble vitamin, is well known as an anticoagulant in the clinic. It is essential for the post-translational activation of VK-dependent proteins (VKDPs) because hydroquinone VK is a cofactor of glutamine carboxylase. At present, 17 VKDPs are known, which are mainly involved in coagulation and calcification. When Glu residues are carboxylated to Gla residues, these proteins gain a higher calcium-binding ability, which explains why VK has an important role in blood coagulation and biominera… Show more

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