Rolipram versus nortriptyline in gerontopsychiatric inpatients with major depression

Abstract

A, Sastre-y-Hernindez M, Bischoff R, Schratzer M, Voet B. Rolipram versus nortriptyline in gerontopsychiatric inpatients with major depression. Nord J Psychiatry 1992;46:407-411. Oslo. To define the therapeutic profile of the new putative antidepressant rolipram, a doubleblind (double-dummy) study with 0.5 mg rolipram versus 25 mg nortriptyline three times daily was conducted in hospitalized gerontopsychiatric inpatients with major depression. During both therapies, improvement was achieved compared with base line. However, the rate of recovery in patients treated with 3x25 mg nortriptyline was significantly greater than in those treated with 3~0 . 5 mg rolipram. Overall, rolipram was better tolerated than nortriptyline and produced fewer adverse effects that could be attributed to cholinergic blocking. We conclude that 3X0.5 mg rolipram presumably is too low a dosage for the treatment of major depression in gerontopsychiatric inpatients. Antidepressants, Gerontopsychiatry, Major depression, Phosphodiesterase inhibitors, Rolipram.Nord J Psychiatry Downloaded from informahealthcare.com by University of Newcastle on 01/03/15For personal use only.

Efficacy of treatment in older depressed patients: A systematic review and meta-analysis of double-blind randomized controlled trials with antidepressants

“…Twenty-one RCTs were excluded because they did not use antidepressants but acetyl-L-carnitine (Bella et al, 1990;Gecele et al, 1991), ACTH 4-9 analog (Frederiksen et al, 1985), adinazolam (Feighner et al, 1990), brofaromine (Moller and Volz, 1993), diclofensine (Gentili et al, 1984;Jansen et al, 1982), flupenthixol (Hostmaelingen et al, 1989), lithium (Wilkinson et al, 2002), methylphenidate (Wallace et al, 1995), nimodipine (Taragano et al, 2001(Taragano et al, , 2005, perphenazine (Meyers et al, 2001), procaine (Aslan et al, 1986;Bălăceanu-Stolnici et al, 1996), rolipram (Behnke et al, 1992), St. John's Wort (Harrer et al, 1999), sulpiride (Kivelä and Lehtomäki, 1987), tryptophan (Cooper and Datta, 1980;Rousseau, 1987), or combined fluphenazine/nortriptyline (Brodie et al, 1975).…”