Roller compaction and tableting of microcrystalline cellulose/drug mixtures

Inghelbrecht, Sabine; Remon, Jean Paul

doi:10.1016/s0378-5173(97)00356-6

Cited by 91 publications

(34 citation statements)

References 9 publications

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“…Microcrystalline cellulose is chosen as a model compound because it is a widely used pharmaceutical excipient and its mechanical properties are well understood. There have been a number of publications that studied the effect of roller compaction on microcrystalline cellulose [5][6][7] as well as the physical, chemical, and mechanical properties of microcrystalline cellulose. [8][9][10][11][12][13][14][15][16] The objective of this study was to utilize out-of-die Heckel analysis, tablet tensile strength data, and indentation hardness data to evaluate the reasons for the loss of reworkability seen in microcrystalline cellulose.…”

Section: Introductionmentioning

confidence: 99%

Mechanistic Study of the Effect of Roller Compaction and Lubricant on Tablet Mechanical Strength

Secreast

Amidon

2007

Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

Mechanistic Study of the Effect of Roller Compaction and Lubricant on Tablet Mechanical Strength

Secreast

Amidon

2007

Journal of Pharmaceutical Sciences

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“…High E/P y ratio is related to the large plastic zone and significant degree of material surrounding the indenter, which could consequently be displaced upward along the plastic flow. A certain percent of pharmaceutical materials possess strain-hardening properties (72)(73)(74). In such cases, the material becomes harder with subsequent plastic deformations, which constrains its upward flow.…”

Section: Pile-up and Sink-inmentioning

confidence: 99%

Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients

2016

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Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients # Nanoindentation allows quantitative determination of a material's response to stress such as elastic and plastic deformation or fracture tendency. Key instruments that have enabled great advances in nanomechanical studies are the instrumented nanoindenter and atomic force microscopy. The versatility of these instruments lies in their capability to measure local mechanical response, in very small volumes and depths, while monitoring time, displacement and force with high accuracy and precision. This review highlights the application of nanoindentation for mechanical characterization of pharmaceutical materials in the preformulation phase (primary investigation of crystalline active ingredients and excipients). With nanoindentation, mechanical response can be assessed with respect to crystal structure. The technique is valuable for mechanical screening of a material at an early development phase in order to predict and better control the processes in which a material is exposed to stress such as milling and compression.

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“…Several studies dealing with the effect of different granulation methods on the dissolution rate of API show that such a form of processing can heavily influence the dissolution rate (5)(6)(7)(8)(9). However, these works differ in their results.…”

mentioning

confidence: 72%

Analysis of Drug Release from Different Agglomerates Using a Mathmatical Model

Petrů¹,

Zámostný²

2014

Dissolution Technol.

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The release rate of an active ingredient from a dosage form may be affected by the agglomeration of an active ingredient before tablet compression. This study is aimed at establishing the effects of the agglomerates on active ingredient release profiles. A model substance, caffeine, was tested in the powdered form and in the two agglomerated forms prepared by wet granulation and compaction. The profiles of caffeine release from these forms were measured using a flow-through cell dissolution apparatus (USP 4) in an open-loop arrangement. To identify the particular processes responsible for the differences in the dissolution profiles of the model forms, we developed a mathematical description of the dissolution profiles. Using this mathematical approach, we proposed that caffeine was adsorbed to the microcrystalline cellulose present in the granulated and compacted form and that diffusion of the active ingredient was inhibited in the presence of a binder in the granulate. Both of these effects resulted in imperfections in the shape of dissolution profiles and in a decrease in the dissolution rate of caffeine. The mathematical model is based on generic parameters, thus it is transferable to other pharmaceutical substances in powdered and agglomerated forms.

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Roller compaction and tableting of microcrystalline cellulose/drug mixtures

Cited by 91 publications

References 9 publications

Mechanistic Study of the Effect of Roller Compaction and Lubricant on Tablet Mechanical Strength

Mechanistic Study of the Effect of Roller Compaction and Lubricant on Tablet Mechanical Strength

Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients

Analysis of Drug Release from Different Agglomerates Using a Mathmatical Model

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