Romatoid Artritli Hastalarda ADMA Düzeyleri ile Karotid Arter Intima-Media Kalınlığı Arasındaki İlişkinin Saptanması

Karaoğlan, Belgin; Öztürk, Gökhan Tuna; Özdoğan, Vildan; Cumaoğlu, Ahmet; Oktar, Suna Özhan; Taş, Nihal; Aricioglu, Aysel

doi:10.4274/tftr.27879

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…17 , ItalyASpCE-UV81738.010/70.54 ± 0.071739.010/70.65 ± 0.10Karaoglan et al . 48 , TurkeyRAsLC-FLR71846.32/160.4 ± 0.161849.42/160.52 ± 0.19Saadany et al . 21 , EgyptSLEsELISA62031.40/200.58 ± 0.053030.10/300.68 ± 0.02Topal et al .…”

Section: Resultsmentioning

confidence: 98%

Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases

Erre

Mangoni

Castagna

et al. 2019

Sci Rep

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Raised circulating concentrations of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), have been reported in several rheumatic diseases (RDs). However, the strength of this relationship is unclear. Therefore, the aim of this systematic review and meta-analysis was to evaluate the magnitude and the robustness of the association between ADMA concentrations and RDs. We calculated standardized mean differences (SMD, with 95% confidence intervals, CI). Study heterogeneity was evaluated by meta-regressions and sensitivity analyses according to type of RDs, conventional cardiovascular risk factors, inflammatory markers, and type of ADMA assessment methodology. Thirty-seven studies with a total of 2,982 subjects (1,860 RDs patients and 1,122 healthy controls) were included in our meta-analysis. Pooled results showed that ADMA concentrations were significantly higher in patients with RDs than in healthy controls (SMD = 1.27 µmol/L, 95% CI 0.94–1.60 µmol/L; p < 0.001). However, the between-studies heterogeneity was high. Differences in ADMA concentrations between controls and RDs patients were not significantly associated with inflammatory markers, increasing age, lipid concentrations, body mass index, blood pressure, or methodology used to assess ADMA. Furthermore, subgroup analysis showed no difference across RDs. This meta-analysis showed that, in the context of significant between-study heterogeneity, circulating concentrations of ADMA are positively related to RDs.

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Section: Resultsmentioning

confidence: 98%

Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases

Erre

Mangoni

Castagna

et al. 2019

Sci Rep

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Elevated circulating asymmetric dimethylarginine levels in rheumatoid arthritis: a systematic review and meta-analysis

Zhao

Mao

et al. 2019

Amino Acids

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Endothelial injury in rheumatoid arthritis: a crosstalk between dimethylarginines and systemic inflammation

et al. 2017

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BackgroundSymmetric (SDMA) and asymmetric (ADMA) dimethylarginines have emerged as novel biomarkers of cardiovascular disease (CVD) in several disease settings associated with atherosclerosis. Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by high CVD mortality and morbidity. ADMA and SDMA levels are abnormal in RA patients, but their correlation with assessments of endothelial function and structure remains unknown. We aimed to investigate whether SDMA and ADMA are associated with carotid intima media thickness (cIMT) and arterial stiffness as well as non-invasive assessments of in vivo micro- and macrovascular endothelial function in RA patients with high systemic inflammatory load.MethodADMA and SDMA levels were measured using immunoassays in 197 RA individuals. Twenty-six of these [23 (86.4%) females, median age 70, quartiles (60, 73)] were identified as having high inflammatory markers [erythrocyte sedimentation rate (ESR) >25 mm/hr and C-reactive protein (CRP) > 5 mg/L], and were compared to the remainder of the cohort. Patients underwent assessments of microvascular endothelium-dependent and endothelium-independent function [laser Doppler imaging with iontophoresis of acetylcholine (Ach) and sodium-nitroprusside (SNP) respectively], macrovascular endothelium-dependent and endothelium-independent function (flow-mediated dilatation and glyceryl-trinitrate-mediated dilation respectively), and vascular morphology [pulse wave analysis, and carotid intima media thickness (cIMT)].ResultsSignificant interactions with inflammation were detected in the associations between ACh and both SDMA (p = 0.014) and ADMA:SDMA ratio (p = 0.027), as well as between SNP and SDMA (p = 0.042) and between arterial stiffness and ADMA:SDMA (p = 0.036), with the associations being stronger in the patients with high inflammatory markers in each case.ConclusionsBesides their emerging role as markers of endothelial dysfunction SDMA and ADMA may promote endothelial injury in RA as mediators of the adverse effects of systemic inflammation on micro- and macrovasculature respectively in patients with active disease.

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Romatoid Artritli Hastalarda ADMA Düzeyleri ile Karotid Arter Intima-Media Kalınlığı Arasındaki İlişkinin Saptanması

Cited by 4 publications

References 31 publications

Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases

Meta-Analysis of Asymmetric Dimethylarginine Concentrations in Rheumatic Diseases

Elevated circulating asymmetric dimethylarginine levels in rheumatoid arthritis: a systematic review and meta-analysis

Endothelial injury in rheumatoid arthritis: a crosstalk between dimethylarginines and systemic inflammation

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